Comparing Patient-Reported Outcomes From Sham and Saline-Based Placebo Injections for Knee Osteoarthritis: Data From a Randomized Clinical Trial of Lorecivivint

1. Altman, RD, Devji, T, Bhandari, M, Fierlinger, A, Niazi, F, Christensen, R. Clinical benefit of intra-articular saline as a comparator in clinical trials of knee osteoarthritis treatments: A systematic review and meta-analysis of randomized trials. Semin Arthritis Rheum. 2016;46(2):151-159. doi:10.1016/J.SEMARTHRIT.2016.04.003
Google Scholar | Crossref | Medline2. Bang, H, Ni, L, Davis, CE. Assessment of blinding in clinical trials. Control Clin Trials. 2004;25(2):143-156. doi:10.1016/J.CCT.2003.10.016
Google Scholar | Crossref | Medline3. Bannuru, RR, McAlindon, TE, Sullivan, MC, Wong, JB, Kent, DM, Schmid, CH. Effectiveness and implications of alternative placebo treatments: a systematic review and network meta-analysis of osteoarthritis trials. Ann Intern Med. 2015;163(5):365-372. doi:10.7326/M15-0623
Google Scholar | Crossref | Medline | ISI4. Bannuru, RR, Schmid, CH, Kent, DM, Vaysbrot, EE, Wong, JB, McAlindon, TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis. Ann Intern Med. 2015;162(1):46-54. doi:10.7326/M14-1231
Google Scholar | Crossref | Medline | ISI5. Cross, M, Smith, E, Hoy, D, et al. The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis. 2014;73(7):1323-1330. doi:10.1136/annrheumdis-2013-204763
Google Scholar | Crossref | Medline | ISI6. da Costa, BR, Reichenbach, S, Keller, N, et al. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet. 2017; 390(10090):e21-e33. doi:10.1016/S0140-6736(17)31744-0
Google Scholar | Crossref | Medline7. Deshmukh, V, O’Green, AL, Bossard, C, et al. Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment. Osteoarthritis Cartilage. 2019;27:1347-1360. doi:10.10 16/j.joca.2019.05.006
Google Scholar | Crossref | Medline8. Desmarais, MHL . Value of intra-articular injections in osteo-arthritis: a controlled series. Ann Rheum Dis. 1952;11(4):277-281.
Google Scholar | Crossref | Medline9. McAlindon, TE, Bannuru, RR, Sullivan, MC, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014;22(3):363-388. doi:10.1016/j.joca.2014.01.003
Google Scholar | Crossref | Medline | ISI10. Miller, JH, White, J, Norton, TH. The value of intra-articular injections in osteoarthritis of the knee. J Bone Joint Surg Br. 1958;40(4):636-643.
Google Scholar | Crossref | Medline11. Previtali, D, Merli, G, Di Laura Frattura, G, Candrian, C, Zaffagnini, S, Filardo, G. The long-lasting effects of “placebo injections” in knee osteoarthritis: a meta-analysis. Cartilage. Published online March 18, 2020. doi:10.1177/1947603520906597
Google Scholar | SAGE Journals12. Roberts, E, Nunes, VD, Buckner, S, et al. Paracetamol: not as safe as we thought? A systematic literature review of observational studies. Ann Rheum Dis. 2016;75(3):552-559. doi:10.1136/annrheumdis-2014-206914
Google Scholar | Crossref | Medline13. Rossettini, G, Carlino, E, Testa, M. Clinical relevance of contextual factors as triggers of placebo and nocebo effects in musculoskeletal pain. BMC Musculoskelet Disord. 2018;19(1):27. doi:10.1186/S12891-018-1943-8
Google Scholar | Crossref | Medline14. Saltzman, BM, Leroux, T, Meyer, MA, et al. The therapeutic effect of intra-articular normal saline injections for knee osteoarthritis: a meta-analysis of evidence level 1 studies. Am J Sports Med. 2017;45(11):2647-2653. doi:10.1177/0363546516680607
Google Scholar | SAGE Journals | ISI15. Strand, V, Boers, M, Idzerda, L, et al. It’s good to feel better but it’s better to feel good and even better to feel good as soon as possible for as long as possible: response criteria and the importance of change at OMERACT 10. J Rheumatol. 2011;38(8):1720-1727. doi:10.3899/jrheum.110392
Google Scholar | Crossref | Medline16. Wolfe, F, Clauw, DJ, Fitzcharles, MA, et al. Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR preliminary diagnostic criteria for fibromyalgia. J Rheumatol. 2011;38(6):1113-1122. doi:10.3899/jrheum.100594
Google Scholar | Crossref | Medline17. Yazici, Y, McAlindon, TE, Gibofsky, A, et al. A phase 2b randomized trial of lorecivivint, a novel intra-articular CLK2/DYRK1A inhibitor and Wnt pathway modulator for knee osteoarthritis. Osteoarthritis Cartilage. 2021;29(5):654-666. doi:10.1016/j.joca.2021.02.004
Google Scholar | Crossref | Medline18. Zhang, W, Robertson, J, Jones, AC, Dieppe, PA, Doherty, M. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann Rheum Dis. 2008;67(12):1716-1723. doi:10.1136/ard.2008.092015
Google Scholar | Crossref | Medline | ISI

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