Funding information:

F.T.C. has received research support from the Singapore Ministry of Education Academic Research Fund, Singapore Immunology Network (SIgN), National Medical Research Council (NMRC) (Singapore), Biomedical Research Council (BMRC) (Singapore), and the Agency for Science Technology and Research (A*STAR) (Singapore); Grant Numbers: N-154-000-038-001, R-154-000-191-112, R-154-000-404-112, R-154-000-553-112, R-154-000-565-112, R-154-000-630-112, R-154-000-A08-592, R-154-000-A27-597, R-154-000-A91-592, R-154-000-A95-592, R154-000-B99-114, BMRC/01/1/21/18/077, BMRC/04/1/21/19/315, BMRC/APG2013/108, SIgN-06-006, SIgN-08-020, NMRC/1150/2008 and H17/01/a0/008. The funding agencies had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. F.T.C. has also received consulting fees from outside the submitted work.