Introduction/Aims

Recently, our group found an association between diabetes mellitus (DM) and lumbosacral radiculoplexus neuropathy (LRPN) in Olmsted County, Minnesota; we found a higher risk (OR: 7.91) for developing LRPN in diabetic compared to non-diabetic patients. However, the influence of other comorbidities and anthropomorphic variables was not studied.

Methods

Demographic and clinical data from 59 LRPN patients and 177 age-sex matched controls were extracted using the Rochester LRPN epidemiological study. Differences between groups were compared by Chi-square/Fisher's exact test or Wilcox sum rank. Univariate and multivariate logistic regression analysis were performed.

Results

Factors predictive of LRPN on univariate analysis were DM (OR 7.91; CI 4.11-15.21), dementia (OR 6.36; CI 1.13-35.67), stroke (OR 3.81; CI 1.32-11.01), dyslipidemia (OR 2.844; CI 1.53-5.27), comorbid autoimmune disorders (OR 2.72; CI 1.07-6.93), hypertension (OR 2.25; CI 1.2-4.13), obesity (OR 2.05; CI 1.11-3.8), BMI (OR 1.1; CI 1.04-1.15), and weight (OR 1.02; CI 1.009-1.037). On multivariate logistic regression analysis only DM (OR 8.03; CI 3.86-16.7), comorbid autoimmune disorders (OR 4.58; CI 1.45-14.7), stroke (OR 4.13; CI 1.2-14.25) and BMI (OR 1.07; CI 1.01-1.13) were risk factors for LRPN.

Discussion

DM is the strongest risk factor for the development of LRPN, followed by comorbid auto-immune disorders, stroke and higher BMI. Altered metabolism and immune dysfunction seem to be the most influential factors in the development of LRPN.

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