Molecular pain and the 2021 Nobel Prize in Physiology or Medicine

1. Caterina, MJ, Schumacher, MA, Tominaga, M, Rosen, TA, Levine, JD, Julius, D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997; 389: 816–824.
Google Scholar | Crossref | Medline | ISI2. Peier, AM, Moqrich, A, Hergarden, AC, Reeve, AJ, Andersson, DA, Story, GM, Earley, TJ, Dragoni, I, McIntyre, P, Bevan, S, Patapoutian, A. A TRP channel that senses cold stimuli and menthol. Cell 2002; 108: 705–715.
Google Scholar | Crossref | Medline | ISI3. McKemy, DD, Neuhausser, WM, Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 2002; 416: 52–58.
Google Scholar | Crossref | Medline | ISI4. Coste, B, Mathur, J, Schmidt, M, Earley, TJ, Ranade, S, Petrus, MJ, Dubin, AE, Patapoutian, A. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 2010; 330: 55–60.
Google Scholar | Crossref | Medline | ISI5. Ikeda, R, Cha, M, Ling, J, Jia, Z, Coyle, D, Gu, JG. Merkel cells transduce and encode tactile stimuli to drive Abeta-afferent impulses. Cell 2014; 157: 664–675.
Google Scholar | Crossref | Medline | ISI6. Maksimovic, S, Nakatani, M, Baba, Y, Nelson, AM, Marshall, KL, Wellnitz, SA, Firozi, P, Woo, SH, Ranade, S, Patapoutian, A, Lumpkin, EA. Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature 2014; 509: 617–621.
Google Scholar | Crossref | Medline | ISI7. Woo, SH, Ranade, S, Weyer, AD, Dubin, AE, Baba, Y, Qiu, Z, Petrus, M, Miyamoto, T, Reddy, K, Lumpkin, EA, Stucky, CL, Patapoutian, A. Piezo2 is required for Merkel-cell mechanotransduction. Nature 2014; 509: 622–626.
Google Scholar | Crossref | Medline | ISI

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