The stress associated with coronavirus disease 2019 (COVID-19) has affected the mental health of the general public, but the infection may cause psychiatric syndromes more directly.

We describe a 44-year-old male whose mental state deteriorated gradually from the start of COVID-19 infection. He developed a manic episode with psychotic features, which led to psychiatric admission. Psychopharmacotherapy with two mood stabilizers caused a quick resolution of symptoms. After a few weeks, the patient has presented symptoms of a moderate depressive episode.

COVID-19 infection and its treatment may lead to the onset of bipolar disorder.