Connexin-43 Enhances the Redesigned Cytosine Deaminase Activity for Suicide Gene Therapy in Human Breast Cancer Cells

1. Edelstein, ML, Abedi, MR, Wixon, J. Gene therapy clinical trials worldwide to 2007 – an update. J Gene Med. 2007;9:833–842.
Google Scholar | Crossref | Medline | ISI2. Freeman, SM . Suicide gene therapy. InCancer Gene Therapy 2002 (pp. 411–422). Springer, Boston, MA.
Google Scholar | Crossref3. Lv, S-Q, Zhang, KB, Zhang, EE. Antitumor efficiency of the cytosine deaminase/5-fluorocytosine suicide gene therapy system on malignant gliomas: an in vivo study. Med Sci Monit. 2008;15:BR13-BR20.
Google Scholar4. Lawrence, TS, Davis, MA, Maybaum, J. Dependence of 5-fluorouracil-mediated radiosensitization on DNA-directed effects. Int J Radiat Oncol Biol Phys. 1994;29:519–523.
Google Scholar | Crossref5. Yagiz, K, Rodriguez-Aguirre, ME, Lopez Espinoza, F. A retroviral replicating vector encoding cytosine deaminase and 5-FC induces immune memory in metastatic colorectal cancer models. Mol Ther Oncolytics. 2018;8:14–26.
Google Scholar | Crossref6. Greco, O, Dachs, GU. Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives. J Cell Physiol. 2001;187:22–36.
Google Scholar | Crossref | Medline7. Raza, A, Ghoshal, A, Chockalingam, S, Ghosh, SS. Connexin-43 enhances tumor suppressing activity of artesunate via gap junction-dependent as well as independent pathways in human breast cancer cells. Sci Rep. 2017;7:7580.
Google Scholar | Crossref8. Raza, A, Kohila, V, Ghosh, SS. Redesigned Escherichia coli cytosine deaminase: a new facet of suicide gene therapy. J Gene Med. 2015;17:132–139.
Google Scholar | Crossref9. Riccardi, C, Nicoletti, I. Analysis of apoptosis by propidium iodide staining and flow cytometry. Nat Protoc. 2006;1:1458–1461.
Google Scholar | Crossref | Medline | ISI10. Harris, BE, Manning, BW, Federle, TW, Diasio, RB. Conversion of 5-fluorocytosine to 5-fluorouracil by human intestinal microflora. Antimicrob Agents Chemother. 1986;29:44–48.
Google Scholar | Crossref11. Cohen, M, Minsky, B, Schilsky, R. Colon cancer. In: De Vita, VT, Hellman, S, Rosenberg, SA, eds. Cancer: Principles & Practice of Oncology, 4th ed. 1993: 29–1005.
Google Scholar12. Moertel, C, Childs, DS, Reitemeier, RJ, Colby, MY, Holbrook, MA. Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet. 1969;2:865–867.
Google Scholar | Crossref | Medline | ISI13. Rothenberg, ML, Moore, MJ, Cripps, MC. A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer. Ann Oncol. 1996;7:347–353.
Google Scholar | Crossref | Medline | ISI14. Bunz, F, Hwang, PM, Torrance, C. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest. 1999;104:263–269.
Google Scholar | Crossref | Medline | ISI15. West, TP, Shanley, MS, O’Donovan, GA. Purification and some properties of cytosine deaminase from Salmonella typhimurium. Biochim Biophys Acta. 1982;719:251–258.
Google Scholar | Crossref16. Weinreb, RN. Adjusting the dose of 5-fluorouracil after filtration surgery to minimize side effects. Ophthalmology. 1987;94:564–570.
Google Scholar | Crossref17. Kohila, V, Jaiswal, A, Ghosh, SS. Rationally designed Escherichia coli cytosine deaminase mutants with improved specificity towards the prodrug 5-fluorocytosine for potential gene therapy applications. MedChemComm. 2012;3:1316–1322.
Google Scholar | Crossref18. King, TJ, Bertram, JS. Connexins as targets for cancer chemoprevention and chemotherapy. Biochim Biophys Acta. 2005;1719:146–160.
Google Scholar | Crossref19. McLachlan, E, Shao, Q, Laird, DW. Connexins and gap junctions in mammary gland development and breast cancer progression. J Membr Biol. 2007;218:107–121.
Google Scholar | Crossref20. Kandouz, M, Batist, G. Gap junctions and connexins as therapeutic targets in cancer. Expert Opin Ther Targets. 2010;14: 681–692.
Google Scholar | Crossref21. Huang, R-P, Fan, Y, Hossain, MZ, Peng, A, Zeng, ZL, Boynton, AL. Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43). Cancer Res. 1998;58:5089–5096.
Google Scholar | Medline | ISI22. Zhang, Y, Kaneda, M, Morita, I. The gap junction-independent tumor-suppressing effect of connexin 43. J Biol Chem. 2003;278:44852–44856.
Google Scholar | Crossref | Medline23. Zhou, JZ, Jiang, JX. Gap junction and hemichannel-independent actions of connexins on cell and tissue functions – an update. FEBS Lett. 2014;588:1186–1192.
Google Scholar | Crossref

留言 (0)

沒有登入
gif