The Role of Insulin-Like Growth Factors and Insulin-Like Growth Factor–Binding Proteins in the Nervous System

1. Barzilai, N, Huffman, DM, Muzumdar, RH, Bartke, A. The critical role of metabolic pathways in aging. Diabetes. 2012;61:1315–1322.
Google Scholar | Crossref | Medline2. Reinhardt, RR, Bondy, CA. Insulin-like growth factors cross the blood-brain barrier. Endocrinology. 1994;135:1753–1761.
Google Scholar | Crossref | Medline | ISI3. Le Roith, D, Bondy, C, Yakar, S, Liu, JL, Butler, A. The somatomedin hypothesis: 2001. Endocr Rev. 2001;22:53–74.
Google Scholar | Crossref | Medline | ISI4. Firth, SM, Baxter, RC. Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev. 2002;23:824–854.
Google Scholar | Crossref | Medline | ISI5. Nakae, J, Kido, Y, Accili, D. Distinct and overlapping functions of insulin and IGF-I receptors. Endocr Rev. 2001;22:818–835.
Google Scholar | Crossref | Medline | ISI6. Belfiore, A, Frasca, F, Pandini, G, Sciacca, L, Vigneri, R. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev. 2009;30:586–623.
Google Scholar | Crossref | Medline | ISI7. Denley, A, Cosgrove, LJ, Booker, GW, Wallace, JC, Forbes, BE. Molecular interactions of the IGF system. Cytokine Growth Factor Rev. 2005;16:421–439.
Google Scholar | Crossref | Medline8. Bondy, CA, Cheng, CM. Signaling by insulin-like growth factor 1 in brain. Eur J Pharmacol. 2004;490:25–31.
Google Scholar | Crossref | Medline | ISI9. Scott, CD, Firth, SM. The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal? Horm Metab Res. 2004;36:261–271.
Google Scholar | Crossref10. Daza, DO, Sundstrom, G, Bergqvist, CA, Duan, C, Larhammar, D. Evolution of the insulin-like growth factor binding protein (IGFBP) family. Endocrinology. 2011;152:2278–2289.
Google Scholar | Crossref11. Baxter, RC . IGF binding proteins in cancer: mechanistic and clinical insights. Nat Rev Cancer. 2014;14:329–341.
Google Scholar | Crossref12. Clemmons, DR . Role of IGF binding proteins in regulating metabolism. Trends Endocrinol. Metab. 2016;27:375–391.
Google Scholar | Crossref | Medline13. Salmon, WD, Daughaday, WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957;49:825–836.
Google Scholar | Medline14. Boisclair, YR, Rhoads, RP, Ueki, I, Wang, J, Ooi, GT. The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten component of the circulating IGF system. J Endocrinol. 2001;170:63–70.
Google Scholar | Crossref | Medline15. Clemmons, DR . Metabolic actions of insulin-like growth factor-I in normal physiology and diabetes. Endocrinol Metab Clin North Am. 2012;41:425–443, vii-viii.
Google Scholar | Crossref | Medline16. Muller, EE, Locatelli, V, Cocchi, D. Neuroendocrine control of growth hormone secretion. Physiol Rev. 1999;79:511–607.
Google Scholar | Crossref17. Russo, VC, Rekaris, G, Baker, NL, Bach, LA, Werther, GA. Basic fibroblast growth factor induces proteolysis of secreted and cell membrane-associated insulin-like growth factor binding protein-2 in human neuroblastoma cells. Endocrinology. 1999;140:3082–3090.
Google Scholar | Crossref18. Mendes, KN, Wang, GK, Fuller, GN, Zhang, W. JNK mediates insulin-like growth factor binding protein 2/integrin alpha5-dependent glioma cell migration. Int J Oncol. 2010;37:143–153.
Google Scholar19. Grotendorst, GR, Lau, LF, Perbal, B. CCN proteins are distinct from and should not be considered members of the insulin-like growth factor-binding protein superfamily. Endocrinology. 2000;141:2254–2256.
Google Scholar | Crossref20. O’Kusky, J, Ye, P. Neurodevelopmental effects of insulin-like growth factor signaling. Front Neuroendocrinol. 2012;33:230–251.
Google Scholar | Crossref | Medline21. Rotwein, P, Burgess, SK, Milbrandt, JD, Krause, JE. Differential expression of insulin-like growth factor genes in rat central nervous system. Proc Natl Acad Sci U S A. 1988;85:265–269.
Google Scholar | Crossref | Medline | ISI22. Bondy, CA, Werner, H, Roberts, CT, Le Roith, D. Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression. Mol Endocrinol. 1990;4:1386–1398.
Google Scholar | Crossref | Medline23. Frago, LM, Paneda, C, Dickson, SL, Hewson, AK, Argente, J, Chowen, JA. Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin- like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection. Endocrinology. 2002;143:4113–4122.
Google Scholar | Crossref | Medline | ISI24. Hojvat, S, Baker, G, Kirsteins, L, Lawrence, AM. Growth hormone (GH) immunoreactivity in the rodent and primate CNS: distribution, characterization and presence posthypophysectomy. Brain Res. 1982;239:543–557.
Google Scholar | Crossref25. Sun, LY, Al-Regaiey, K, Masternak, MM, Wang, J, Bartke, A. Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice. Neurobiol Aging. 2005;26:929–937.
Google Scholar | Crossref | ISI26. Walser, M, Sama, MT, Wickelgren, R. Local overexpression of GH and GH/IGF1 effects in the adult mouse hippocampus. J Endocrinol. 2012;215:257–268.
Google Scholar | Crossref27. Pulford, BE, Ishii, DN. Uptake of circulating insulin-like growth factors (IGFs) into cerebrospinal fluid appears to be independent of the IGF receptors as well as IGF-binding proteins. Endocrinology. 2001;142:213–220.
Google Scholar | Crossref | Medline | ISI28. Yan, H, Mitschelen, M, Bixler, GV. Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence. J Endocrinol. 2011;211:27–37.
Google Scholar | Crossref29. Nishijima, T, Piriz, J, Duflot, S. Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS. Neuron. 2010;67:834–846.
Google Scholar | Crossref | Medline | ISI30. Carro, E, Spuch, C, Trejo, JL, Antequera, D, Torres-Aleman, I. Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. J Neurosci. 2005;25:10884–10893.
Google Scholar | Crossref31. Lehtinen, MK, Bjornsson, CS, Dymecki, SM, Gilbertson, RJ, Holtzman, DM, Monuki, ES. The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy. J Neurosci. 2013;33:17553–17559.
Google Scholar | Crossref32. Carlsson-Skwirut, C, Jörnvall, H, Holmgren, A. Isolation and characterization of variant IGF-1 as well as IGF-2 from adult human brain. FEBS Lett. 1986;201:46–50.
Google Scholar | Crossref33. Bond, AM, Ming, GL, Song, H. Adult mammalian neural stem cells and neurogenesis: five decades later. Cell Stem Cell. 2015;17:385–395.
Google Scholar | Crossref | Medline34. Lehtinen, MK, Zappaterra, MW, Chen, X. The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron. 2011;69:893–905.
Google Scholar | Crossref | Medline | ISI35. Holzenberger, M, Jarvis, ED, Chong, C, Grossman, M, Nottebohm, F, Scharff, C. Selective expression of insulin-like growth factor II in the songbird brain. J Neurosci. 1997;17:6974–6987.
Google Scholar | Crossref36. D’Ercole, AJ, Ye, P, O’Kusky, JR. Mutant mouse models of insulin-like growth factor actions in the central nervous system. Neuropeptides. 2002;36:209–220.
Google Scholar | Crossref | Medline37. Mathews, LS, Hammer, RE, Behringer, RR. Growth enhancement of transgenic mice expressing human insulin-like growth factor I. Endocrinology. 1988;123:2827–2833.
Google Scholar | Crossref38. van Buul-Offers, SC, de Haan, K, Reijnen-Gresnigt, MG. Overexpression of human insulin-like growth factor-II in transgenic mice causes increased growth of the thymus. J Endocrinol. 1995;144:491–502.
Google Scholar | Crossref39. Cheng, CM, Mervis, RF, Niu, SL. Insulin-like growth factor 1 is essential for normal dendritic growth. J Neurosci Res. 2003;73:1–9.
Google Scholar | Crossref40. Cheng, CM, Joncas, G, Reinhardt, RR. Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition. J Neurosci. 1998;18:5673–5681.
Google Scholar | Crossref41. Dikkes, P, Hawkes, C, Kar, S, Lopez, MF. Effect of kainic acid treatment on insulin-like growth factor-2 receptors in the IGF2-deficient adult mouse brain. Brain Res. 2007;1131:77–87.
Google Scholar | Crossref42. Dikkes, PDBJ, B Jaffe, D, Guo, WH. IGF2 knockout mice are resistant to kainic acid-induced seizures and neurodegeneration. Brain Res. 2007;1175:85–95.
Google Scholar | Crossref43. Baker, AM, Batchelor, DC, Thomas, GB. Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat. Neuropeptides. 2005;39:81–87.
Google Scholar | Crossref | Medline44. Ballard, FJ, Wallace, JC, Francis, GL, Read, LC, Tomas, FM. Des(1-3)IGF-I – a truncated form of insulin-like growth-factor-I. Int J Biochem Cell Biol. 1996;28:1085–1087.
Google Scholar | Crossref45. Bourguignon, J, Gerard, A. Role of insulin-like growth factor binding proteins in limitation of IGF-I degradation into the N-methyl-D-aspartate receptor antagonist GPE: evidence from gonadotrophin-releasing hormone secretion in vitro at two developmental stages. Brain Res. 1999;847:247–252.
Google Scholar | Crossref46. Ikeda, T, Waldbillig, RJ, Puro, DG. Truncation of IGF-I yields two mitogens for retinal Muller glial cells. Brain Res. 1995;686:87–92.
Google Scholar | Crossref47. Sara, VR, Carlsson-Skwirut, C, Bergman, T. Identification of GLY-PRO-GLU (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide. Biochem Biophys Res Commun. 1989;165:766–771.
Google Scholar | Crossref48. Alexi, T, Hughes, PE, van Roon-Mom, WM. The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington’s disease. Exp Neurol. 1999;159:84–97.
Google Scholar | Crossref49. Saura, J, Curatolo, L, Williams, CE. Neuroprotective effects of Gly-Pro-Glu, the N-terminal tripeptide of IGF-1, in the hippocampus in vitro. Neuroreport. 1999;10:161–164.
Google Scholar | Crossref50. Kleinridders, A, Ferris, HA, Cai, W, Kahn, CR. Insulin action in brain regulates systemic metabolism and brain function. Diabetes. 2014;63:2232–2243.
Google Scholar | Crossref51. Baron-Van Evercooren, A, Olichon-Berthe, C, Kowalski, A, Visciano, G, Van Obberghen, E. Expression of IGF-I and insulin receptor genes in the rat central nervous system: a developmental, regional, and cellular analysis. J Neurosci Res. 1991;28:244–253.
Google Scholar | Crossref52. Liu, J-P, Baker, J, Perkins, AS, Robertson, EJ, Efstratiadis, A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and the type 1 IGF receptor (Igf1r). Cell. 1993;75:59–72.
Google Scholar | Medline | ISI53. Schubert, M, Gautam, D, Surjo, D. Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A. 2004;101:3100–3105.

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