1. Martel-Pelletier, J, Boileau, C, Pelletier, J-P, Roughley, PJ. Cartilage in normal and osteoarthritis conditions. Best Pract Res Clin Rheumatol. 2008;22:351-384.
Google Scholar | Crossref | Medline | ISI2. Arnold, W, Fullerton, DS, Holder, S, May CS. Viscosupplementation: managed care issues for osteoarthritis of the knee. J Manag Care Pharm. 2007;13:S3-S19.
Google Scholar | Medline3. McIntyre, LF, Beach, W, Bhattacharyya, S, Yadalam, S, Bisson, B, Kim, M. Impact of hyaluronic acid injections on utilization of pain management medications. Am J Pharm Benefits. 2017;9:195-199.
Google Scholar4. Hsu, H, Siwiec, R. Knee osteoarthritis. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK507884/. Updated 2020. Accessed December 13, 2020.
Google Scholar5. Food and Drug Administration . Approval letter for Hyalgan. US Department of Health and Human Services. https://www.accessdata.fda.gov/cdrh_docs/pdf/P950027a.pdf. Updated 1997. Accessed December 13, 2020.
Google Scholar6. Food and Drug Administration . Approval letter for Synvisc. US Department of Health and Human Services. https://www.accessdata.fda.gov/cdrh_docs/pdf/P940015a.pdf. Updated 1997. Accessed December 13, 2020.
Google Scholar7. Tamer, TM. Hyaluronan and synovial joint: function, distribution and healing. Interdiscip Toxicol. 2013;6:111-125.
Google Scholar | Crossref | Medline8. Balazs, E . Chapter 20. Viscoelastic properties of hyaluronan and its therapeutic use. In: Garg, H, Hales, C, eds. Chemistry and Biology of Hyaluronan. Amsterdam, The Netherlands: Elsevier Science; 2004:415-455.
Google Scholar | Crossref9. Berenbaum, F, Grifka, J, Cazzaniga, S, et al. A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic knee osteoarthritis. Ann Rheum Dis. 2012;71:1454-1460.
Google Scholar | Crossref | Medline | ISI10. Bannuru, RR, Osani, M, Vaysbrot, EE, McAlindon, TE. Comparative safety profile of hyaluronic acid products for knee osteoarthritis: a systematic review and network meta-analysis. Osteoarthritis Cartilage. 2016;24:2022-2041.
Google Scholar | Crossref | Medline11. Bannuru, R, Natov, N, Dasi, U, Schmid, C, McAlindon, T. Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis—meta-analysis. Osteoarthritis Cartilage. 2011;19:611-619.
Google Scholar | Crossref | Medline | ISI12. Altman, R, Hackel, J, Niazi, F, Shaw, P, Nicholls, M. Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: a systematic review. Semin Arthritis Rheum. 2018;48:168-175.
Google Scholar | Crossref | Medline13. Bannuru, RR, Natov, NS, Obadan, IE, Price, LL, Schmid, CH, McAlindon, TE. Therapeutic trajectory of hyaluronic acid versus corticosteroids in the treatment of knee osteoarthritis: a systematic review and meta-analysis. Arthritis Rheum. 2009;61:1704-1711.
Google Scholar | Crossref | Medline14. Bannuru, RR, Schmid, CH, Kent, DM, Vaysbrot, EE, Wong, JB, McAlindon, TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162:46-54.
Google Scholar | Crossref | Medline | ISI15. Colen, S, van den Bekerom, MP, Mulier, M, Haverkamp, D. Hyaluronic acid in the treatment of knee osteoarthritis: a systematic review and meta-analysis with emphasis on the efficacy of different products. BioDrugs. 2012;26:257-268.
Google Scholar | Crossref | Medline | ISI16. Jevsevar, D, Donnelly, P, Brown, GA, Cummins, DS. Viscosupplementation for osteoarthritis of the knee: a systematic review of the evidence. J Bone Joint Surg Am. 2015;97:2047-2060.
Google Scholar | Crossref | Medline | ISI17. Miller, LE, Block, JE. US-approved intra-articular hyaluronic acid injections are safe and effective in patients with knee osteoarthritis: systematic review and meta-analysis of randomized, saline-controlled trials. Clin Med Insights Arthritis Musculoskelet Disord. 2013;6:57-63.
Google Scholar | SAGE Journals18. Rutjes, AW, Juni, P, da Costa, BR, Trelle, S, Nuesch, E, Reichenbach, S. Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. Ann Intern Med. 2012;157:180-191.
Google Scholar | Crossref | Medline | ISI19. Strand, V, McIntyre, LF, Beach, WR, Miller, LE, Block, JE. Safety and efficacy of US-approved viscosupplements for knee osteoarthritis: a systematic review and meta-analysis of randomized, saline-controlled trials. J Pain Res. 2015;8:217-228.
Google Scholar | Medline | ISI20. Department of Veterans Affairs . VA/DoD clinical practice guideline for the non-surgical management of hip and knee osteoarthritis. Department of Defense. https://www.healthquality.va.gov/guidelines/cd/oa/index.asp. Updated July, 2020. Accessed November 30, 2020.
Google Scholar21. Bannuru, RR, Osani, M, Vaysbrot, E, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019;27:1578-1589.
Google Scholar | Crossref | Medline22. Kolasinski, SL, Neogi, T, Hochberg, MC, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Rheumatol. 2020;72:220-233.
Google Scholar | Crossref | Medline23. Altman, R, Lim, S, Steen, RG, Dasa, V. Hyaluronic acid injections are associated with delay of total knee replacement surgery in patients with knee osteoarthritis: evidence from a large U.S. Health Claims Database. PLoS ONE. 2015;10:e0145776.
Google Scholar | Crossref24. Dasa, V, Lim, S, Heeckt, P. Real-world evidence for safety and effectiveness of repeated courses of hyaluronic acid injections on the time to knee replacement surgery. Am J Orthop (Belle Mead NJ). 2018;47:7.
Google Scholar25. Ong, KL, Runa, M, Lau, E, Altman, R. Is Intra-articular injection of Synvisc associated with a delay to knee arthroplasty in patients with knee osteoarthritis. Cartilage. 2019;10:423-431.
Google Scholar | SAGE Journals | ISI26. Waddell, DD, Bricker, DC. Total knee replacement delayed with Hylan G-F 20 use in patients with grade IV osteoarthritis. J Manag Care Pharm. 2007;13:113-121.
Google Scholar | Crossref | Medline27. Ong, K, Lau, E, Runa, M, Daley, W, Altman, R. Factors associated with knee arthroplasty in a knee osteoarthritis patient cohort treated with intra-articular injections of Hylan G-F 20. J Knee Surg. 2021;34:886-897.
Google Scholar | Crossref | Medline28. Fine, M. Quantifying the impact of NSAID-associated adverse events. Am J Manag Care. 2013;19:s267-s272.
Google Scholar29. Florence, C, Zhou, C, Luo, F, Xu, L. The economic burden of prescription opioid overdose, abuse and dependence in the United States, 2013. Med Care. 2016;54:901-906.
Google Scholar | Crossref | Medline | ISI30. Delcò, F, Michetti, P, Beglinger, C, Fried, M, Szucs, TD. Health care resource utilization and costs of NSAID-induced gastrointestinal toxicity. Digestion. 2004;69:10-19.
Google Scholar | Crossref | Medline31. Cooper, C, Chapurlat, R, Al-Daghri, N, et al. Safety of oral non-selective non-steroidal anti-inflammatory drugs in osteoarthritis: what does the literature say. Drugs Aging. 2019;36:15-24.
Google Scholar | Crossref | Medline32. Kompel, AJ, Roemer, FW, Murakami, AM, Diaz, LE, Crema, MD, Guermazi, A. Intra-articular corticosteroid injections in the hip and knee: perhaps not as safe as we thought? Radiology. 2019;293:656-663.
Google Scholar | Crossref | Medline33. Chitnis, AS, Etter, K, Holy, CE, et al. Real world impact of the high concentration non-avian high molecular weight hyaluronan on pain medication use among osteoarthritis patients. Curr Med Res Opin. 2019;35:1523-1527.
Google Scholar | Crossref | Medline34. Weick, JW, Bawa, HS, Dirschl, DR. Hyaluronic acid injections for treatment of advanced osteoarthritis of the knee: utilization and cost in a national population sample. J Bone Joint Surg Am. 2016;98:1429-1435.
Google Scholar | Crossref | Medline35. Bedard, NA, Dowdle, SB, Anthony, CA, et al. The AAHKS Clinical Research Award: what are the costs of knee osteoarthritis in the year prior to total knee arthroplasty? J Arthroplasty. 2017;32:S8-S10.e11.
Google Scholar | Crossref36. Mackowiak, J, Jones, JT, Dasa, V. A comparison of 4-year total medical care costs, adverse outcomes, and opioid/prescription analgesic use for 3 knee osteoarthritis pain treatments: intra-articular hyaluronic acid, intra-articular corticosteroids, and knee arthroplasty. Semin Arthritis Rheum. 2020;50:1525-1534.
Google Scholar | Crossref | Medline37. Ong, KL, Runa, M, Lau, E, Altman, RD. Cost-of-illness of knee osteoarthritis: potential cost savings by not undergoing arthroplasty within the first 2 years. Clinicoecon Outcomes Res. 2019;11:245-255.
Google Scholar | Crossref | Medline38. Dasa, V, DeKoven, M, Sun, K, Scott, A, Lim, S. Clinical and cost outcomes from different hyaluronic acid treatments in patients with knee osteoarthritis: evidence from a US health plan claims database. Drugs Context. 2016;5:212296.
Google Scholar | Crossref | Medline39. Schmajuk, G, Bozic, KJ, Yazdany, J. Using Medicare data to understand low-value health care: the case of intra-articular hyaluronic acid injections. JAMA Intern Med. 2014;174:1702-1704.
Google Scholar | Crossref | Medline40. Waddell, D, Rein, A, Panarites, C, Coleman, PM, Weiss, C. Cost implications of introducing an alternative treatment for patients with osteoarthritis of the knee in a managed care setting. Am J Manag Care. 2001;7:981-991.
Google Scholar | Medline41. Hatoum, HT, Fierlinger, AL, Lin, SJ, Altman, RD. Cost-effectiveness analysis of intra-articular injections of a high molecular weight bioengineered hyaluronic acid for the treatment of osteoarthritis knee pain. J Med Econ. 2014;17:326-337.
Google Scholar | Crossref | Medline42. Miller, LE, Block, JE. An 8-week knee osteoarthritis treatment program of hyaluronic acid injection, deliberate physical rehabilitation, and patient education is cost effective at 2 years follow-up: the OsteoArthritis Centers of America (SM) experience. Clin Med Insights Arthritis Musculoskelet Disord. 2014;7:49-55.
Google Scholar | SAGE Journals43. Rosen, J, Niazi, F, Dysart, S. Cost-effectiveness of treating early to moderate stage knee osteoarthritis with intra-articular hyaluronic acid compared to conservative interventions. Adv Ther. 2020;37:344-352.
Google Scholar | Crossref | Medline44. Samuelson, EM, Ebel, JA, Reynolds, SB, Arnold, RM, Brown, DE. The cost-effectiveness of platelet-rich plasma compared with hyaluronic acid injections for the treatment of knee osteoarthritis. Arthroscopy. 2020;36:3072-3078.
Google Scholar | Crossref | Medline45. Rosen, J, Sancheti, P, Fierlinger, A, Niazi, F, Johal, H, Bedi, A. Cost-effectiveness of different forms of intra-articular injections for the treatment of osteoarthritis of the knee. Adv Ther. 2016;33:998-1011.
Google Scholar | Crossref | Medline46. Rosen, J, Sancheti, P, Fierlinger, A, Niazi, F, Johal, H, Bedi, A. Potential impact of biologically derived hyaluronic acid on quality of life in patients with knee osteoarthritis in the United States. Adv Ther. 2017;33:2200-2210.
Google Scholar | Crossref | Medline47. Miller, LE, Sloniewsky, MJ, Gibbons, TE, Johnston, JG, Vosler, KD, Nasir, S. Long-term clinical benefit and cost-effectiveness of an 8-week multimodal knee osteoarthritis management program incorporating intra-articular sodium hyaluronate (Hyalgan(®)) injections. J Pain Res. 2017;10:1045-1054.
Google Scholar | Crossref | Medline48. Bhadra, AK, Altman, R, Dasa, V, et al. Appropriate use criteria for hyaluronic acid in the treatment of knee osteoarthritis in the United States. Cartilage. 2017;8:234-254.
Google Scholar | SAGE Journals | ISI49. Zeng, C, Lane, NE, Hunter, DJ, et al. Intra-articular corticosteroids and the risk of knee osteoarthritis progression: results from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2019;27:855-862.
Google Scholar | Crossref | Medline50. Osani, MC, Lohmander, LS, Bannuru, RR. Is there any role for opioids in the management of knee and hip osteoarthritis? A systematic review and meta-analysis [published online ahead of print June 25, 2020]. Arthritis Care Res (Hoboken). doi:10.1002/acr.24363.