F. Lu1, D-J Zhai2, F-F. Liu2 and B-J. Ji3

Author information

1ECG Room, East District of Yantaishan Hospital, Yantai, China;
2Department of Cardiology, Jiyang People’s Hospital of Jinan, Jinan, China;
3Blood Transfusion Department, Weifang People’s Hospital, Weifang, China

Abstract

To provide a scientific basis for clinical treatment of patients with chronic heart failure, we explored the effect of obstructive sleep apnea on laboratory indicators of patients with chronic heart failure. A total of 76 patients with chronic heart failure admitted to our hospital from January 2019 to May 2020 were selected. According to whether obstructive sleep apnea occurred, the patients were divided into normal group and observation group, with 45 cases and 31 cases respectively. The levels of inflammatory factors (TNF-α, IL-6, IL-8), cardiac function indexes (SV, LVEF, FS, CO) and vascular endothelial function (FMD, GMD) were compared between the two groups. The TNF-α, IL-6, and IL-8 levels in the normal group were 312.25 ± 26.12 ng/L, 78.62 ± 8.24 ng/L, and 139.25 ± 19.88 ng/L, while they were 428.75 ±30.23 ng/L, 151.56 ±15.69 ng/L, and 187.33 ±20.26 ng/L in the observation group. In the normal group, SV was 78.76 ± 4.27 ml/time, LVEF was 51.08 ± 3.65 %, LVFS was 27.59 ± 3.44 %, and CO was 5.72 ± 1.07 L/min. But SV was 70.58 ± 4.63 ml/time, LVEF was 46.22 ± 3.74 %, LVFS was 21.86 ± 4.24 %, CO was 4.64 ±1.02 L/min in observation group. The FMD was 9.27 ± 1.25 %, and the GMD was 22.08 ± 2.24 % in the normal group. In the observation group, the FMD was 6.73 ± 1.19 %, and the GMD was 18.87 ± 2.13 %. The differences of all above indictors were statistically significant (P<0.05). Obstructive sleep apnea in patients with chronic heart failure will aggravate the inflammatory response and affect the normal function of heart function and vascular endothelial function, which should be paid attention to in clinical practice.

Keywords:

obstructive sleep apnea, chronic heart failure, inflammatory factors, heart function, vascular endothelial function

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