Genome-wide summary statistics for the intermediate risk factors and the outcome variables (CHD and PAD) that were used to select SNPs for this study are publicly available (see references in Table 1). Due to institutional review board regulations, individual level data from the Mayo Vascular Disease biorepository are not available.

Software implementing the proposed tests for mediation for quantitative traits is available as an R package called “regmed” in the Comprehensive R Archive Network (CRAN).