Axelstad, M, Boberg, J, Nellemann, C, et al. (2011) Exposure to the widely used fungicide mancozeb causes thyroid hormone disruption in rat dams but no behavioral effects in the offspring. Toxicological Sciences 120(2): 439–446.
Google Scholar | Crossref | Medline Balaji, B, Rajendar, B, Ramanathan, M (2014) Quercetin protected isolated human erythrocytes against mancozeb-induced oxidative stress. Toxicology and Industrial Health 30(6): 561–569.
Google Scholar | SAGE Journals | ISI Belpoggi, F, Soffritti, M, Guarino, M, et al. (2002) Results of long-term experimental studies on the carcinogenicity of ethylene-bis-dithiocarbamate (Mancozeb) in rats. Annals of the New York Academy of Sciences 982(1): 123–136.
Google Scholar | Crossref | Medline Bianchi, S, Nottola, SA, Torge, D, et al. (2020) Association between female reproductive health and mancozeb: Systematic review of experimental models. International Journal of Environmental Research and Public Health 17(7): 2580.
Google Scholar | Crossref Bui, A, Sharma, R, Henkel, R, et al. (2018) Reactive oxygen species impact on sperm DNA and its role in male infertility. Andrologia 50(8): e13012.
Google Scholar | Crossref | Medline Calviello, G, Piccioni, E, Boninsegna, A, et al. (2006) DNA damage and apoptosis induction by the pesticide mancozeb in rat cells: involvement of the oxidative mechanism. Toxicology and Applied Pharmacology 211(2): 87–96.
Google Scholar | Crossref | Medline Choi, MS, Park, HJ, Oh, JH, et al. (2014) Nonylphenol induced apoptotic cell death in mouse TM4 sertoli cells via the generation of reactive oxygen species and activation of the ERK signaling pathway. Journal of Applied Toxicology 34(6): 628–636.
Google Scholar | Crossref | Medline Corsini, E, Birindelli, S, Fustinoni, S, et al. (2005) Immunomodulatory effects of the fungicide mancozeb in agricultural workers. Toxicology and applied pharmacology 208(2): 178–185.
Google Scholar | Crossref | Medline Costa-Silva, DG, Lopes, AR, Martins, IK, et al. (2018) Mancozeb exposure results in manganese accumulation and Nrf2-related antioxidant responses in the brain of common carp cyprinus carpio. Environmental Science and Pollution Research 25(16): 15529–15540.
Google Scholar | Crossref | Medline Da Silva Gündel, S, Dos Reis, TR, Copetti, PM, et al. (2019) Evaluation of cytotoxicity, genotoxicity and ecotoxicity of nanoemulsions containing mancozeb and eugenol. Ecotoxicology and Environmental Safety 169: 207–215.
Google Scholar | Crossref | Medline Domico, LM, Cooper, KR, Bernard, LP, et al. (2007) Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology 28(6): 1079–1091.
Google Scholar | Crossref | Medline | ISI Elsharkawy, EE, El-Nasser, MA, Bakheet, AA (2019) Mancozeb impaired male fertility in rabbits with trials of glutathione detoxification. Regulatory Toxicology and Pharmacology 105: 86–98.
Google Scholar | Crossref | Medline Eluka-Okoludoh, E, Ewunkem, A, Thorpe, S, et al. (2018) Diepoxybutane-induced apoptosis is mediated through the ERK1/2 pathway. Human & Experimental Toxicology 37(10): 1080–1091.
Google Scholar | SAGE Journals | ISI Girish, BP, Reddy, PS (2017) Forskolin ameliorates mancozeb-induced testicular and epididymal toxicity in wistar rats by reducing oxidative toxicity and by stimulating steroidogenesis. Journal of Biochemical and Molecular Toxicology 32: e22026.
Google Scholar | Crossref Grosicka-Maciąg, E, Kurpios-Piec, D, Szumiło, M, et al. (2012) Dithiocarbamate fungicide zineb induces oxidative stress and apoptosis in Chinese hamster lung fibroblasts. Pesticide Biochemistry and Physiology 102(1): 95–101.
Google Scholar | Crossref Jablonická, A, Poláková, H, Karelová, J, et al. (1989) Analysis of chromosome aberrations and sister-chromatid exchanges in peripheral blood lymphocytes of workers with occupational exposure to the mancozeb-containing fungicide Novozir Mn80. Mutation Research/Genetic Toxicology 224(2): 143–146.
Google Scholar | Crossref | Medline Joshi, SC, Gulati, N, Gajraj, A (2005) Evaluation of toxic impacts of mancozeb on testis in rats. Asian Journal of Experimental Sciences 19(1): 73–83.
Google Scholar Kinkel, AD, Fernyhough, ME, Helterline, DL, et al. (2004) Oil red-O stains non-adipogenic cells: A precautionary note. Cytotechnology 46(1): 49–56.
Google Scholar | Crossref | Medline Liu, Y, Wang, Y-L, He, S-W, et al. (2017) Protective effects of resveratrol against mancozeb induced apoptosis damage in mouse oocytes. Oncotarget 8(4): 6233–6245.
Google Scholar | Crossref | Medline Liu, L, Chang, X, Zhang, Y, et al. (2018) Fluorochloridone induces primary cultured sertoli cells apoptosis: Involvement of ROS and intracellular calcium ions-mediated ERK1/2 activation. Toxicology In Vitro 47: 228–237.
Google Scholar | Crossref | Medline Mitra, S, Srivastava, A, Khandelwal, S (2013) Tributyltin chloride induced testicular toxicity by JNK and p38 activation, redox imbalance and cell death in sertoli-germ cell co-culture. Toxicology 314(1): 39–50.
Google Scholar | Crossref | Medline Mohammadi-Sardoo, M, Mandegary, A, Nabiuni, M, et al. (2018) Mancozeb induces testicular dysfunction through oxidative stress and apoptosis: Protective role of N-acetylcysteine antioxidant. Toxicology and industrial health 34(11): 798–811.
Google Scholar | SAGE Journals Ohkawa, H, Ohishi, N, Yagi, K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 95(2): 351–358.
Google Scholar | Crossref | Medline | ISI Ozmen, O, Mor, F (2012) Apoptosis in adult rabbit testes during subacute endosulfan toxicity. Pesticide biochemistry and physiology 102(2): 129–133.
Google Scholar | Crossref Pavlovic, V, Cekic, S, Ciric, M, et al. (2016) Curcumin attenuates mancozeb-induced toxicity in rat thymocytes through mitochondrial survival pathway. Food and Chemical Toxicology 88: 105–111.
Google Scholar | Crossref | Medline Pavlović, V, Cekić, S, Petrović, M (2019) Effect of curcumin and p53 signaling pathway in rat thymocytes toxicity induced by mancozeb. Acta Medica Medianae 58(2): 135–144.
Google Scholar Pirozzi, AVA, Stellavato, A, La Gatta, A, et al. (2016) Mancozeb, a fungicide routinely used in agriculture, worsens nonalcoholic fatty liver disease in the human HepG2 cell model. Toxicology Letters 249: 1–4.
Google Scholar | Crossref | Medline Redza-Dutordoir, M, Averill-Bates, DA (2016) Activation of apoptosis signalling pathways by reactive oxygen species. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1863(12): 2977–2992.
Google Scholar | Crossref | Medline Royall, JA, Ischiropoulos, H (1993) Evaluation of 2′,7′-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells. Archives of Biochemistry and Biophysics 302: 348–355.
Google Scholar | Crossref | Medline | ISI Saber, TM, Abo-Elmaaty, AM, Abdel-Ghany, HM (2019) Curcumin mitigates mancozeb-induced hepatotoxicity and genotoxicity in rats. Ecotoxicology and Environmental Safety 183: 109467.
Google Scholar | Crossref | Medline Shi, Y, Song, Y, Wang, Y, et al. (2011) β-benzene hexachloride induces apoptosis of rat sertoli cells through generation of reactive oxygen species and activation of JNKs and FasL. Environmental toxicology 26(2): 124–135.
Google Scholar | Crossref | Medline Simioni, C, Zauli, G, Martelli, AM, et al. (2018) Oxidative stress: Role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget 9(24): 17181–17198.
Google Scholar | Crossref | Medline Srivastava, AK, Ali, W, Singh, R, et al. (2012) Mancozeb-induced genotoxicity and apoptosis in cultured human lymphocytes. Life Sciences 90(21–22): 815–824.
Google Scholar | Crossref | Medline Srivastava, AK, Mishra, S, Ali, W, et al. (2016) Protective effects of lupeol against mancozeb-induced genotoxicity in cultured human lymphocytes. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 23(7): 714–724.
Google Scholar | Crossref | Medline Wang, Z, Kottawatta, KS, Kodithuwakku, SP, et al. (2021) The fungicide mancozeb reduces spheroid attachment onto endometrial epithelial cells through downregulation of estrogen receptor β and integrin β3 in ishikawa cells. Ecotoxicology and Environmental Safety 208: 111606.
Google Scholar | Crossref | Medline Wegner, S, Hong, S, Yu, X, et al. (2013) Preparation of rodent testis co cultures. Chapter 16: Unit 16 10. Current Protocols in Toxicology 55. DOI: 10.1002/0471140856.tx1610s55
Google Scholar | Crossref Weis, GCC, Assmann, CE, Cadoná, FC, et al. (2019) Immunomodulatory effect of mancozeb, chlorothalonil, and thiophanate methyl pesticides on macrophage cells. Ecotoxicology and Environmental Safety 182: 109420.
Google Scholar | Crossref | Medline Yahia, D, El-Amir, YO, Rushdi, M (2019) Mancozeb fungicide-induced genotoxic effects, metabolic alterations, and histological changes in the colon and liver of sprague dawley rats. Toxicology and industrial health 35(4): 265–276.
Google Scholar | SAGE Journals | ISI Yiran, Z, Chenyang, J, Jiajing, W, et al. (2013) Oxidative stress and mitogen-activated protein kinase pathways involved in cadmium-induced BRL 3A cell apoptosis. Oxidative medicine and cellular longevity 2013: 516051.
Google Scholar | Crossref | Medline Zeisel, SH (2004) Antioxidants suppress apoptosis. The Journal of nutrition 134(11): 3179S–3180S.
Google Scholar | Crossref | Medline Zhou, X-R, Jiang, W-B, Zhang, Y-T, et al. (2018) Dibromoacetic acid induced Cl. Ly1+ 2/− 9 T-cell apoptosis and activation of MAPKs signaling cascades. Toxicology In Vitro 47: 156–164.
Google Scholar | Crossref | Medline