Making Sense of the Highly Variable Effects of Alcohol on Bone

1.

Arranz S, Chiva-Blanch G, Valderas-Martinez P, Medina-Remon A, Lamuela-Raventos RM, Estruch R. Wine, beer, alcohol and polyphenols on cardiovascular disease and cancer. Nutrients. 2012;4(7):759–81. https://doi.org/10.3390/nu4070759

Article  PubMed  PubMed Central  Google Scholar 

2.

CDC. Alcohol use and alcohol use disorders in the United States: mail finding from the 2012–2013 National Epidemiologic Survey on alcohol related conditions-III (NESARC-III). Alcohol Epidemiol Data Ref Manual. 2014;10.

3.

Fung TT, Mukamal KJ, Rimm EB, Meyer HE, Willett WC, Feskanich D. Alcohol intake, specific alcoholic beverages, and risk of hip fractures in postmenopausal women and men age 50 and older. Am J Clin Nutr. 2019;110(3):691–700. https://doi.org/10.1093/ajcn/nqz135

Article  PubMed  PubMed Central  Google Scholar 

4.

Santori C, Ceccanti M, Diacinti D, Attilia ML, Toppo L, D’Erasmo E, et al. Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol. J Endocrinol Invest. 2008;31(4):321–6. https://doi.org/10.1007/BF03346365

Article  PubMed  Google Scholar 

5.

Sommer I, Erkkila AT, Jarvinen R, Mursu J, Sirola J, Jurvelin JS, et al. Alcohol consumption and bone mineral density in elderly women. Public Health Nutr. 2013;16(4):704–12. https://doi.org/10.1017/S136898001200331X

Article  PubMed  Google Scholar 

6.

Roy DK, O’Neill TW, Finn JD, Lunt M, Silman AJ, Felsenberg D, et al. Determinants of incident vertebral fracture in men and women: results from the European Prospective Osteoporosis Study (EPOS). Osteoporos Int: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2003;14(1):19–26. https://doi.org/10.1007/s00198-002-1317-8

Article  Google Scholar 

7.

Fini M, Giavaresi G, Salamanna F, Veronesi F, Martini L, De Mattei M, et al. Harmful lifestyles on orthopedic implantation surgery: a descriptive review on alcohol and tobacco use. J Bone Miner Metab. 2011;29(6):633–44. https://doi.org/10.1007/s00774-011-0309-1

Article  PubMed  Google Scholar 

8.

Jung MK, Callaci JJ, Lauing KL, Otis JS, Radek KA, Jones MK, et al. Alcohol exposure and mechanisms of tissue injury and repair. Alcohol Clin Exp Res. 2011;35(3):392–9. https://doi.org/10.1111/j.1530-0277.2010.01356.x

Article  PubMed  Google Scholar 

9.

Ronis MJ, Mercer K, Chen JR. Effects of nutrition and alcohol consumption on bone loss. Curr Osteoporos Rep. 2011;9(2):53–9. https://doi.org/10.1007/s11914-011-0049-0

Article  PubMed  PubMed Central  Google Scholar 

10.

Maurel DB, Boisseau N, Benhamou CL, Jaffre C. Alcohol and bone: review of dose effects and mechanisms. Osteoporos Int: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2012;23(1):1–16. https://doi.org/10.1007/s00198-011-1787-7

Article  Google Scholar 

11.

Turner RT, Doran E, Iwaniec UT. Detrimental effects of alcohol on bone growth. INTECH Open Access Publisher. 2012.

12.

Abukhadir SS, Mohamed N, Mohamed N. Pathogenesis of alcohol-induced osteoporosis and its treatment: a review. Curr Drug Targets. 2013;14(13):1601–10. https://doi.org/10.2174/13894501113146660231

Article  PubMed  Google Scholar 

13.

Gaddini GW, Turner RT, Grant KA, Iwaniec UT. Alcohol: a simple nutrient with complex actions on bone in the adult skeleton. Alcohol Clin Exp Res. 2016;40(4):657–71. https://doi.org/10.1111/acer.13000

Article  PubMed  PubMed Central  Google Scholar 

14.

Luo Z, Liu Y, Liu Y, Chen H, Shi S, Liu Y. Cellular and molecular mechanisms of alcohol-induced osteopenia. Cell Mol Life Sci. 2017;74(24):4443–53. https://doi.org/10.1007/s00018-017-2585-y

Article  PubMed  Google Scholar 

15.

Eby JM, Sharieh F, Callaci JJ. Impact of alcohol on bone health, homeostasis, and fracture repair. Curr Pathobiol Rep. 2020;8:75–86. https://doi.org/10.1007/s40139-020-00209-7

Article  PubMed  Google Scholar 

16.

Dempster DW. Osteoporosis and the burden of osteoporosis-related fractures. Am J Manag Care. 2011;17(Suppl 6):S164–9.

PubMed  Google Scholar 

17.

Viswanathan HN, Curtis JR, Yu J, White J, Stolshek BS, Merinar C, et al. Direct healthcare costs of osteoporosis-related fractures in managed care patients receiving pharmacological osteoporosis therapy. Appl Health Econ Health Policy. 2012;10(3):163–73. https://doi.org/10.2165/11598590-000000000-00000

Article  PubMed  Google Scholar 

18.

Mello NK, Mendelson JH. A quantitative analysis of drinking patterns in alcoholics. Arch Gen Psychiatry. 1971;25(6):527–39.

Article  Google Scholar 

19.

Baker EJ, Farro J, Gonzales S, Helms C, Grant KA. Chronic alcohol self-administration in monkeys shows long-term quantity/frequency categorical stability. Alcohol Clin Exp Res. 2014;38(11):2835–43. https://doi.org/10.1111/acer.12547

Article  PubMed  PubMed Central  Google Scholar 

20.

Hoidrup S, Gronbaek M, Gottschau A, Lauritzen JB, Schroll M. Alcohol intake, beverage preference, and risk of hip fracture in men and women. Copenhagen Centre for Prospective Population Studies. Am J Epidemiol. 1999;149(11):993–1001. https://doi.org/10.1093/oxfordjournals.aje.a009760

21.

Tucker KL, Jugdaohsingh R, Powell JJ, Qiao N, Hannan MT, Sripanyakorn S, et al. Effects of beer, wine, and liquor intakes on bone mineral density in older men and women. Am J Clin Nutr. 2009;89(4):1188–96. https://doi.org/10.3945/ajcn.2008.26765

Article  PubMed  PubMed Central  Google Scholar 

22.

Ganry O, Baudoin C, Fardellone P. Effect of alcohol intake on bone mineral density in elderly women: the EPIDOS study. Epidemiologie de l'Osteoporose. Am J Epidemiol. 2000;151(8):773–80.

23.

Marrone JA, Maddalozzo GF, Branscum AJ, Hardin K, Cialdella-Kam L, Philbrick KA, et al. Moderate alcohol intake lowers biochemical markers of bone turnover in postmenopausal women. Menopause. 2012;19(9):974–9. https://doi.org/10.1097/gme.0b013e31824ac071

Article  PubMed  Google Scholar 

24.

Jadzic J, Cvetkovic D, Milovanovic P, Tomanovic N, Zivkovic V, Nikolic S, et al. The micro-structural analysis of lumbar vertebrae in alcoholic liver cirrhosis. Osteoporos Int: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2020. https://doi.org/10.1007/s00198-020-05509-7

Article  Google Scholar 

25.

Berg KM, Kunins HV, Jackson JL, Nahvi S, Chaudhry A, Harris KA Jr, et al. Association between alcohol consumption and both osteoporotic fracture and bone density. Am J Med. 2008;121(5):406–18. https://doi.org/10.1016/j.amjmed.2007.12.012

Article  PubMed  PubMed Central  Google Scholar 

26.

Felson DT, Zhang Y, Hannan MT, Kannel WB, Kiel DP. Alcohol intake and bone mineral density in elderly men and women. The Framingham Study. Am J Epidemiol. 1995;142(5):485–92.

27.

Holbrook TL, Barrett-Connor E. A prospective study of alcohol consumption and bone mineral density. BMJ. 1993;306(6891):1506–9. https://doi.org/10.1136/bmj.306.6891.1506

Article  PubMed  PubMed Central  Google Scholar 

28.

Jang HD, Hong JY, Han K, Lee JC, Shin BJ, Choi SW, et al. Relationship between bone mineral density and alcohol intake: a nationwide health survey analysis of postmenopausal women. PLoS ONE. 2017;12(6). https://doi.org/10.1371/journal.pone.0180132

Article  PubMed  PubMed Central  Google Scholar 

29.

Laitinen K, Karkkainen M, Lalla M, Lamberg-Allardt C, Tunninen R, Tahtela R, et al. Is alcohol an osteoporosis-inducing agent for young and middle-aged women? Metab: Clin Exp. 1993;42(7):875–81.

30.

Mukamal KJ, Robbins JA, Cauley JA, Kern LM, Siscovick DS. Alcohol consumption, bone density, and hip fracture among older adults: the cardiovascular health study. Osteoporos Int: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2007;18(5):593–602. https://doi.org/10.1007/s00198-006-0287-7

Article  Google Scholar 

31.

Rapuri PB, Gallagher JC, Balhorn KE, Ryschon KL. Alcohol intake and bone metabolism in elderly women. Am J Clin Nutr. 2000;72(5):1206–13. https://doi.org/10.1093/ajcn/72.5.1206

Article  PubMed  Google Scholar 

32.

Wosje KS, Kalkwarf HJ. Bone density in relation to alcohol intake among men and women in the United States. Osteoporos Int: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2007;18(3):391–400. https://doi.org/10.1007/s00198-006-0249-0

Article  Google Scholar 

33.

Seo S, Chun S, Newell MA, Yun M. Association between alcohol consumption and Korean young women's bone health: a cross sectional study from the 2008 to 2011 Korea National Health and Nutrition Examination Survey. BMJ Open. 2015;5(10). https://doi.org/10.1136/bmjopen-2015-007914

Article  PubMed  PubMed Central  Google Scholar 

34.

Sung DJ, Singh H, Oh SB, Kim S. Bone-loading physical activity and alcohol intake but not BMI affect areal bone mineral density in young college-aged Korean women: a cross-sectional study. Int J Environ Res Public Health. 2019;16(24). https://doi.org/10.3390/ijerph16245063

35.

Diamond T, Stiel D, Lunzer M, Wilkinson M, Posen S. Ethanol reduces bone formation and may cause osteoporosis. Am J Med. 1989;86(3):282–8. https://doi.org/10.1016/0002-9343(89)90297-0

Article  PubMed  Google Scholar 

36.

Ulhoi MP, Meldgaard K, Steiniche T, Odgaard A, Vesterby A. Chronic alcohol abuse leads to low bone mass with no general loss of bone structure or bone mechanical strength<sup/> J Forensic Sci. 2017;62(1):131–6. https://doi.org/10.1111/1556-4029.13256

Article  PubMed  Google Scholar 

37.

Gonzalez-Reimers E, Martin-Gonzalez C, de la Vega-Prieto MJ, Pelazas-Gonzalez R, Fernandez-Rodriguez C, Lopez-Prieto J, et al. Serum sclerostin in alcoholics: a pilot study. Alcohol Alcohol. 2013;48(3):278–82. https://doi.org/10.1093/alcalc/ags136

Article  PubMed  Google Scholar 

38.

Paccou J, Edwards MH, Ward K, Jameson K, Moon R, Dennison E, et al. Relationships between bone geometry, volumetric bone mineral density and bone microarchitecture of the distal radius and tibia with alcohol consumption. Bone. 2015;78:122–9. https://doi.org/10.1016/j.bone.2015.05.002

Article  PubMed  Google Scholar 

39.

Pumarino H, Gonzalez P, Oviedo S, Lillo R, Bustamante E. Assessment of bone status in intermittent and continuous alcoholics, without evidence of live damage. Revista medica de Chile. 1998;124:423–30.

40.

Hefferan TE, Kennedy AM, Evans GL, Turner RT. Disuse exaggerates the detrimental effects of alcohol on cortical bone. Alcohol Clin Exp Res. 2003;27(1):111–7. https://doi.org/10.1097/01.ALC.0000047348.23797.6E

Article  PubMed  Google Scholar 

41.

Johnson TL, Gaddini G, Branscum AJ, Olson DA, Caroline-Westerlind K, Turner RT, et al. Effects of chronic heavy alcohol consumption and endurance exercise on cancellous and cortical bone microarchitecture in adult male rats. Alcohol Clin Exp Res. 2014;38(5):1365–72. https://doi.org/10.1111/acer.12366

Article  PubMed  PubMed Central  Google Scholar 

42.

Reed AH, McCarty HL, Evans GL, Turner RT, Westerlind KC. The effects of chronic alcohol consumption and exercise on the skeleton of adult male rats. Alcohol Clin Exp Res. 2002;26(8):1269–74. https://doi.org/10.1097/01.ALC.0000023984.47311.6E

Article  PubMed  Google Scholar 

43.

Iwaniec UT, Turner RT. Intraperitoneal injection of ethanol results in drastic changes in bone metabolism not observed when ethanol is administered by oral gavage. Alcohol Clin Exp Res. 2013;37(8):1271–7. https://doi.org/10.1111/acer.12105

Article  PubMed  PubMed Central  Google Scholar 

44.

Sampson HW, Gallager S, Lange J, Chondra W, Hogan HA. Binge drinking and bone metabolism in a young actively growing rat model. Alcohol Clin Exp Res. 1999;23(7):1228–31. https://doi.org/10.1111/j.1530-0277.1999.tb04282.x

Article  PubMed  Google Scholar 

45.

Turner RT, Evans GL, Zhang M, Sibonga JD. Effects of parathyroid hormone on bone formation in a rat model for chronic alcohol abuse. Alcohol Clin Exp Res. 2001;25(5):667–71.

Article  Google Scholar 

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