IMW Verberk, EJ Nossent and HJ Bontkes report no disclosures. CE Teunissen has a collaboration contract with ADx Neurosciences and Quanterix, and performed contract research for or received grants from AxonNeurosciences, Biogen, Boehringer, Brainstorm Therapeutics, Celgene, EIP Pharma, Esai, Janssen prevention center, Roche, Toyama, Vivoryon. Funding sources had no role in study design, data collection, analysis or interpretation or in writing the report. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.