Meeting Presentation: This study has been accepted for presentation at the Association for Research in Vision and Ophthalmology Annual Meeting, 2021.

Financial Support: NIH/NEI K23EY029246 (Bethesda, MD), NIH/NIA R01AG060942 (Bethesda, MD), Latham Vision Research Innovation Award (Seattle, WA), and an unrestricted grant from Research to Prevent Blindness (New York, NY). The sponsors / funding organizations had no role in the design or conduct of this research.

Conflict of Interest: Dr. Pershing reports support from Acumen, LLC, and Verana Health (consultant). The sponsors had no role in the design or conduct of this research. Dr. A. Lee reports support from the US Food and Drug Administration, grants from Santen, Carl Zeiss Meditec, and Novartis, personal fees from Genentech, Topcon, and Verana Health, outside of the submitted work; This article does not reflect the opinions of the Food and Drug Administration.

This article contains additional online-only material. The following should appear online-only: Supplemental Tables 1, 2, 3, 4 and Supplemental Appendix.

IRIS Registry Analytic Center Consortium

Study Group members not included in the author line

Flora Lum, MD

American Academy of Ophthalmology, San Francisco, CA

Emily Chew, MD

National Eye Institute, Bethesda, MD

Julia A. Haller, MD

Wills Eye Hospital, Philadelphia, PA

Alice C. Lorch, MD, MPH

Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston MA

Joan W. Miller, MD

Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston MA