Disclosure(s): Michael Chiang, an editorial board member of this journal, was recused from the peer-review process of this article and had no access to information regarding its peer-review.

All authors have completed and submitted the ICMJE disclosures form.

The author(s) have made the following disclosure(s): M.F.C.: Consultant – Novartis; Financial support – Genentech; Equity owner – InTeleretina

A.R.F.: Consultant – Novartis, Bayer

R.V.P.C.: Scientific Advisory Board – Phoenix Technology; Consultant – Alcon, Novartis

J.P.C.: Financial support – Genentech

A.C.: Equity owner – Phoenix Technology Group, LLC, Retinal Solutions, LLC; Founder – Retinal Solutions, LLC; Financial support – AURA Biosciences; Bayer; Genentech; Ionis Pharmaceuticals; Novartis; Regeneron Pharmaceuticals

B.W.F.: Consultant – Novartis

M.E.H.: Consultant – Regeneron

B.L.: Consultant – Novartis, Janssen

D.L.: Consultant – Novartis, Bayer

Ş.Ö.: Consultant – Novartis, Bayer, Allergan

A.S.: Consultant – Novartis, Bayer; Financial support – Novartis

C.A.T.: Royalties – Alcon; Founder and Equity owner – Theia Imaging, LLC

W.-C.W.: Consultant – Novartis, Bayer, Allergan

All authors are members of the International Committee for the Classification of Retinopathy of Prematurity.

Michael F. Chiang had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Supported by the Knights Templar Eye Foundation; the Illinois Eye and Ear Infirmary at the University of Illinois at Chicago, Chicago, Illinois; National Institutes of Health, Bethesda, Maryland (grant nos.: R01EY19474 [J.P.C.], K12EY027720 [J.P.C.], R01EY017011 [M.E.H.], F01EY01730 [M.E.H.], EY014800 [M.E.H.], R01EY025009 [C.A.T.], U01EY028079 [C.A.T.], P30EY005722 [C.A.T.], P30EY001792, and P30EY10572); the National Science Foundation (SCH-1622679 [J.P.C.]); Research to Prevent Blindness, Inc., New York, New York (unrestricted departmental funding, Career Development Award [J.P.C.], and Stein Award [C.A.T.]); and the Calvin S. and JeNeal N. Hatch Presidential Endowed Chair in Ophthalmology and Visual Sciences (M.E.H.). The sponsor or funding organization had no role in the design or conduct of this research.

Presented in part at: American Academy of Ophthalmology Annual Meeting, November 2020 (virtual); and the American Association for Pediatric Ophthalmology & Strabismus Annual Meeting, April 2021 (virtual).

HUMAN SUBJECTS: No human subjects were included in this study. The requirement for informed consent was waived because of the retrospective nature of the study. All research adhered to the tenets of the Declaration of Helsinki.

No animal subjects were included in this study.

Author Contributions:

Conception and design: Chiang, Quinn, Fielder, Ostmo, Chan, Berrocal, Binenbaum, Blair, Campbell, Capone, Chen, Dai, Ells, Fleck, Good, Hartnett, Holmstrom, Kusaka, Kychenthal, Lepore, Lorenz, Martinez-Castellanos, Özdek, Ademola-Popoola, Reynolds, Shah, Shapiro, Stahl, Toth, Vinekar, Visser, Wallace, Wu, Zhao, Zin

Analysis and interpretation: Chiang, Quinn, Fielder, Ostmo, Chan, Berrocal, Binenbaum, Blair, Campbell, Capone, Chen, Dai, Ells, Fleck, Good, Hartnett, Holmstrom, Kusaka, Kychenthal, Lepore, Lorenz, Martinez-Castellanos, Özdek, Ademola-Popoola, Reynolds, Shah, Shapiro, Stahl, Toth, Vinekar, Visser, Wallace, Wu, Zhao, Zin

Data collection: Chiang, Quinn, Fielder, Ostmo, Chan, Berrocal, Binenbaum, Blair, Campbell, Capone, Chen, Dai, Ells, Fleck, Good, Hartnett, Holmstrom, Kusaka, Kychenthal, Lepore, Lorenz, Martinez-Castellanos, Özdek, Ademola-Popoola, Reynolds, Shah, Shapiro, Stahl, Toth, Vinekar, Visser, Wallace, Wu, Zhao, Zin

Obtained funding: Chan, Chiang, Quinn, Fielder, Ostmo, Campbell, Hartnett, Toth; Study was performed as part of the authors' regular employment duties. No additional funding was provided.

Overall responsibility: Chiang, Quinn, Fielder, Ostmo, Chan, Berrocal, Binenbaum, Blair, Campbell, Capone, Chen, Dai, Ells, Fleck, Good, Hartnett, Holmstrom, Kusaka, Kychenthal, Lepore, Lorenz, Martinez-Castellanos, Özdek, Ademola-Popoola, Reynolds, Shah, Shapiro, Stahl, Toth, Vinekar, Visser, Wallace, Wu, Zhao, Zin