Title:Potential Roles of MyomiRs in Cardiac Development and Related Diseases

VOLUME: 17 ISSUE: 4

Author(s):Leila Abkhooie, Mostafa M. Sarabi*, Houman Kahroba, Shirin Eyvazi, Soheila Montazersaheb, Vahideh Tarhriz* and Mohammad S. Hejazi

Affiliation:Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Department of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Science, Khorramabad, Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz

Keywords:MyomiRs, epigenetic, cardiac development, cardiac diseases, microRNA, cardiac regeneration.

Abstract:Muscle-specific miRNAs, which are known as MyomiRs, are crucial regulatory elements for cardiovascular development. MyomiRs are abundantly expressed in the myocardium and regulate certain aspects of physiological and pathological processes in myocardiocytes, including cardiovascular development, myocardial remodeling, and arise for cardiovascular diseases through different mechanisms, such as epigenetic pathways. Clinical and experimental studies have confirmed the myomiRs as promising diagnostic biomarkers for the early diagnosis of cardiac disorders. In this review, we have summarized recent findings in the field of epigenetic modulations of myomiRs and cardiac regeneration associated with cardiac diseases.