Title:State-of-the-Art Review of Current Therapies for HFpEF: An Overview of Interatrial Septal Device Therapy in Heart Failure

VOLUME: 17 ISSUE: 5

Author(s):Mohammed Al-Sadawi*, Romy R. Ortega, Jonathan Ariyaratnam, Ayman Battisha, Bader Madoukh and Inna Bukharovich

Affiliation:Division of Cardiology, Stony Brook University Hospital, Stony Brook, NY 11720, Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, Department of Internal Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA 01199, Department of Internal Medicine, Overland Park Regional Medical Center-HCA Midwest Health, Overland Park, KS 66215, Department of Cardiovascular Medicine, Kings County Medical Center, Brooklyn, NY 11203

Keywords:Interatrial device, IASD, V-wave, heart failure with preserved ejection fraction, heart failure, device treatment for heart failure.

Abstract:Heart failure (HF) affects an increasing number of geriatric patients. The condition is classified according to whether the left ventricular ejection fraction (EF) is reduced or preserved. Many patients have heart failure with preserved ejection fraction (HFpEF) and face a shortage of effective therapeutic strategies. However, an emerging mechanical strategy for treatment is gaining momentum. Interatrial septal connection devices, i.e. V-wave device and Interatrial septal device, are new devices for patients with heart failure with preserved ejection fraction. We review the function of these systems and the data from the recent clinical trials.

Interatrial septal connection device therapy provided favorable efficacy and safety profile applicable to a wide range of patients with HFpEF. However, the long-term effects of these devices on morbidity