Mansoor Zafar

Specialty Registrar, Gastroenterology and General Internal Medicine. Conquest Hospital. East Sussex Healthcare NHS Foundation Trust, UK.

Ratan Singh Randhawa

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Johannes Hegner

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Saba Alam

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Mariya Farooq

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Reem Eldebri

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Bipin Pun

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Muhamad Shahbaz

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Opeyemi Makanjuola

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Frederic Cuison

Consultant Physician and Gastroenterology. Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Dana Safarova

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Kamal Lawrence

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Amr Elyasaki

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Hesam Nooredinvand

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Manivannan Periasamy

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Lucinda Barry

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Alisha Khanna
Karuna Subba

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Bolurin Adekunle Adekunle

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Oluwamayowa Ojofeitimi

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Mohamed Abdelbagi
Andreia Esteves Morete

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Giulio Ciroi

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Mangala Karkhanis

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Bao Khuu

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Zahra Maryam

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Mirej Patel

Medical Student. University of Debrecen, Hungary

Maaryah Zafar

Medical Student. Universitatea din Oradea. Strada Universitatii nr. 1, 410087. Romania.

Nadiyah Zafar

Medical Student. Universitatea din Oradea. Strada Universitatii nr. 1, 410087. Romania.

Ubaid ur Rehman

Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Steve Moran

Department of Microbiology. Eastbourne District General Hospital. East Sussex Healthcare NHS Trust.

William Alfred ’ O Neill

Department of Microbiology. Eastbourne District General Hospital. East Sussex Healthcare NHS Trust.

Abubakr Hadid

Consultant General Internal Medicine. Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Raphael Golez

Consultant Ortho-geriatrics. Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Tila Muhammad

Consultant Physician and Gastroenterology. Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Mark Whitehead

Consultant Physician and Gastroenterology. Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Umesh Dashora

Supervising Consultant Diabetes and Endocrinology and General Internal Medicine. Conquest Hospital. East Sussex Healthcare NHS Foundation Trust.

Background;

Diabetes mellitus has shown to be a significant risk factor for patients with coronavirus (SARS-CoV-2). HbA1c levels are often used as marker of poor glycaemic control. We explored whether HbA1c levels could be used as an independent risk factor for mortality and morbidity in patients with positive coronavirus (SARS-CoV-2) swabs.

Methods;

This was a retrospective, multi-centre study of coronavirus (SARS-CoV-2) swab positive patients who had a recent HbA1c test. Patients were divided into three groups; HbA1c in normal range (group 1), pre-diabetic range (group 2) and diabetic range (group 3). All statistical analysis was done using Stata Version 16 (StataCorp Texas).

 

Results;

A total of 1226 patients had SARS-CoV-2 RNA swabs between 10th February 2020 and 1st May 2020.  A cohort of 120 of these patients had positive swabs and recent HbA1c. Mortality rates for group 1 and 3 were relatively higher than group 2. For mortality assessed by HbA1c as a continuous variable there was significant non-linearity(p=0.001).

Conclusions;

HbA1c levels in this study were an independent marker of increased risk of mortality and morbidity in SARS-CoV-2 swab positive patients. Increased comorbidities at normal HbA1c may have contributing role in enhanced mortality.