Traumatic brain injury (TBI) represents a significant public health concern with an estimated global incidence of 69 million people per year and is a leading cause of morbidity and mortality among young adults [1], [2]. Patients with TBI can present with a broad spectrum of injuries, with severity ranging from mild to moderate to severe based on the Glasgow Coma Scale (GCS). The most common causes of TBI include road traffic accidents, falls, and physical assaults as well as repetitive sports-related head trauma (e.g., football, boxing) and blast-related injuries [3], [4]. Disrupted functioning of the pituitary gland (hypopituitarism) has been increasingly recognized as a potential consequence of TBI that can lead to delayed and/or impaired physical, neurocognitive, and psychosocial recovery. In this review, we discuss the current standards and our approach to the detection and treatment of hypopituitarism in adults with TBI.