Allergen-Immuntherapie 2025: Evidenz trifft Leitlinien

Pfaar O, Bousquet J, Durham SR, Kleine-Tebbe J, Larché M, Roberts G et al. One hundred and ten years of Allergen Immunotherapy: A journey from empiric observation to evidence. Allergy 2022;77:454-68

Bousquet J, Lockey R, Malling HJ, Alvarez-Cuesta E, Canonica GW, Chapman MD et al. Allergen immunotherapy: therapeutic vaccines for allergic diseases. World Health Organization. American academy of Allergy, Asthma and Immunology. Ann Allergy Asthma Immunol 1998;81:401-5

European Medicines Agency. Commitee for medicinal products for human use (CHMP): Guideline on the Clinical Development of Products for Specific Immunotherapy for The Treatment of Allergic Diseases (CHMP/EWP/18504/2006); www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003605.pdf; 2008; letzter Zugriff: 11.4.2025

Verordnung über die Ausdehnung der Vorschriften über die Zulassung der Arzneimittel auf Therapieallergene, die für einzelne Personen auf Grund einer Rezeptur hergestellt werden, sowie über Verfahrensregelungen der staatlichen Chargenprüfung (Therapieallergene-Verordnung). Bundesgesetzblatt 2008;2177-8

Pfaar O, Hamelmann E, Taube C, Wagenmann M, Wedi B, Werfel T et al. DGAKI and PEI in dialogue 2023: Diagnostics and allergen immunotherapy. Allergol Select 2023;7:229-35

Pfaar O, Ankermann T, Augustin M, Bubel P, Böing S, Brehler R et al. Guideline on allergen immunotherapy in IgE-mediated allergic diseases: S2K Guideline of the German Society of Allergology and Clinical Immunology (DGAKI), Society of Pediatric Allergology and Environmental Medicine (GPA), Medical Association of German Allergologists (AeDA), Austrian Society of Allergology and Immunology (OGAI), Swiss Society for Allergology and Immunology (SSAI), German Dermatological Society (DDG), German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), German Society of Pediatrics and Adolescent Medicine (DGKJ), Society of Pediatric Pulmonology (GPP), German Respiratory Society (DGP), German Professional Association of Otolaryngologists (BVHNO), German Association of Paediatric and Adolescent Care Specialists (BVKJ), Federal Association of Pneumologists, Sleep and Respiratory Physicians (BdP), Professional Association of German Dermatologists (BVDD). Allergol Select 2022;6:167-232

https://dgaki.de/leitlinien/s2k-leitlinie-ait; letzter Zugriff: 11.4.2025

Zielen S, Bernstein JA, Sturm GJ, Jutel M, Pfaar O; RESONATE Investigator Group et al. Six Injections of Modified Adjuvanted PQ Grass Is Effective and Well-Tolerated in a Pivotal Phase III Trial. Allergy 2025; https://doi.org/10.1111/all.16491

Schuster A, Caimmi D, Nolte H, Novakova S, Mikler J, Foss-Skiftesvik MH et al. Efficacy and safety of SQ house dust mite sublingual immunotherapy-tablet (12 SQ-HDM) in children with allergic rhinitis/rhinoconjunctivitis with or without asthma (MT-12): a randomised, double-blind, placebo-controlled, phase III trial. Lancet Reg Health Eur 2025;48:101136

Gappa M, Gagnon R, Horak F, Cichocka-Jarosz E, Dalgaard T, Hargreaves K et al. The SQ tree sublingual immunotherapy tablet is effective and well tolerated in children-A pivotal phase III trial. Allergy 2025;80:795-806

https://eaaci.org/agenda/eaaci-congress-2024/sessions/eaaci-guidelines-key-highlights

Pfaar O, Sousa-Pinto B, Papadopoulos NG, Larenas-Linnemann DE, Ordak M, Torres MJ et al. Digitally-enabled, person-centred care (PCC) in allergen immunotherapy: An ARIA-EAACI Position Paper. Allergy 2024;79:2037-50

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