Advances in Pharmacology and Pharmacy Vol. 13(3), pp. 448 - 457
DOI: 10.13189/app.2025.130315
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Sankara Rao Miditana 1,*, Saivenkatesh Korlam 2, A. Ramesh Babu 3, V. Prabhakar Rao 4, M. Aruna Kumari 5
1 Department of Chemistry, Government Degree College, Puttur, Tirupati, Andhra Pradesh, India
2 Department of Botany, SVA Government Degree College(M), Srikalahasti, Andhra Pradesh, India
3 Department of Chemistry, SVA Government Degree College(M), Srikalahasti, Andhra Pradesh, India
4 Department of Chemistry, Dr.YSR Government Degree College, Vedurukuppam, Andhra Pradesh, India
5 Department of Botany, Government Degree College(A), Nagari, Andhra Pradesh, India

ABSTRACT

Nicotine, a potent alkaloid present in tobacco, is well-known for its highly addictive nature and significant health hazards, such as cancer, heart disease, and respiratory diseases. This review delves into nicotine's comprehensive impact on various biological systems and overall health. It provides a detailed examination of nicotine's detrimental effects on the brain, cardiovascular, respiratory, immune, and reproductive systems, alongside its profound implications for mental health. Despite its well-documented adverse effects, emerging research highlights potential cognitive benefits of nicotine in neurodegenerative conditions such as Parkinson's and Alzheimer's diseases. Specifically, nicotine has demonstrated promise in improving cognitive function in Alzheimer's disease and alleviating dyskinesia and memory problems in Parkinson's disease. These therapeutic effects are thought to be mediated through mechanisms involving Sirtuin 6 inhibition, enhanced protein kinase B activity, and stimulation of phosphoinositide 3-kinase/Akt signaling pathways. Furthermore, this review explores the dual nature of nicotine's impact, emphasizing both its severe health risks and its potential therapeutic benefits, particularly in the context of cognitive disorders. The analysis aims to provide a balanced perspective on nicotine, acknowledging its harmful consequences while also considering its possible utility in specific medical scenarios. Understanding these complex dynamics is crucial for developing effective public health strategies and therapeutic interventions that can mitigate nicotine's risks while potentially harnessing its benefits for treating neurodegenerative diseases. Such a nuanced approach is essential for informing public health policies and advancing therapeutic research, ultimately contributing to improved health outcomes.

KEYWORDS
Addiction, Cognitive Function, Dopamine, Nicotine, Nicotinic Acetylcholine Receptors, Oxidative Stress, Synaptic Plasticity

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Sankara Rao Miditana , Saivenkatesh Korlam , A. Ramesh Babu , V. Prabhakar Rao , M. Aruna Kumari , "Adverse Effects and Therapeutic Potential of Nicotine: A Review," Advances in Pharmacology and Pharmacy, Vol. 13, No. 3, pp. 448 - 457, 2025. DOI: 10.13189/app.2025.130315.

(b). APA Format:
Sankara Rao Miditana , Saivenkatesh Korlam , A. Ramesh Babu , V. Prabhakar Rao , M. Aruna Kumari (2025). Adverse Effects and Therapeutic Potential of Nicotine: A Review. Advances in Pharmacology and Pharmacy, 13(3), 448 - 457. DOI: 10.13189/app.2025.130315.