Volkova M, Russell R 3rd. Anthracycline cardiotoxicity: prevalence, pathogenesis and treatment. Curr Cardiol Rev. 2011;7:214–20. https://doi.org/10.2174/157340311799960645.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Christidi E, Brunham LR. Regulated cell death pathways in doxorubicin-induced cardiotoxicity. Cell Death Dis. 2021;12:339. https://doi.org/10.1038/s41419-021-03614-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van der Zanden SY, Qiao X, Neefjes J. New insights into the activities and toxicities of the old anticancer drug doxorubicin. FEBS J. 2021;288:6095–111. https://doi.org/10.1111/febs.15583.

Article  CAS  PubMed  Google Scholar 

Sheibani M, Azizi Y, Shayan M, et al. Doxorubicin-induced cardiotoxicity: an overview on pre-clinical therapeutic approaches. Cardiovasc Toxicol. 2022;22:292–310. https://doi.org/10.1007/s12012-022-09721-1.

Article  CAS  PubMed  Google Scholar 

Shi S, Chen Y, Luo Z, Nie G, Dai Y. Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy. Cell Commun Signal. 2023;21:61. https://doi.org/10.1186/s12964-023-01077-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bezhaeva T, Karper J, Quax PHA, de Vries MR. The intriguing role of TLR accessory molecules in cardiovascular health and disease. Front Cardiovasc Med. 2022;9:820962. https://doi.org/10.3389/fcvm.2022.820962.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin W, Zhang Y, Xue Y, et al. Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-kappaB signaling: connecting oxidative stress, inflammation, and apoptosis. Naunyn Schmiedebergs Arch Pharmacol. 2020;393:13–23. https://doi.org/10.1007/s00210-019-01704-4.

Article  CAS  PubMed  Google Scholar 

Yang Y, Lv J, Jiang S, et al. The emerging role of Toll-like receptor 4 in myocardial inflammation. Cell Death Dis. 2016;7:e2234. https://doi.org/10.1038/cddis.2016.140.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Riad A, Bien S, Gratz M, et al. Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice. Eur J Heart Fail. 2008;10:233–43. https://doi.org/10.1016/j.ejheart.2008.01.004.

Article  CAS  PubMed  Google Scholar 

El-Ela SRA, Zaghloul RA, Eissa LA. Promising cardioprotective effect of baicalin in doxorubicin-induced cardiotoxicity through targeting toll-like receptor 4/nuclear factor-kappaB and Wnt/beta-catenin pathways. Nutrition. 2022;102:111732. https://doi.org/10.1016/j.nut.2022.111732.

Article  CAS  PubMed  Google Scholar 

Rajsbaum R, Garcia-Sastre A, Versteeg GA. TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity. J Mol Biol. 2014;426:1265–84. https://doi.org/10.1016/j.jmb.2013.12.005.

Article  CAS  PubMed  Google Scholar 

Wang S, Lu B, Liu J, Gu Y. TRIM27 suppresses inflammation injuries in pediatric pneumonia by targeting TLR4/NF-kappaB signaling pathway. Allergol Immunopathol (Madr). 2022;50:33–9. https://doi.org/10.15586/aei.v50i2.558.

Lu M, Zhu X, Yang Z, et al. E3 ubiquitin ligase tripartite motif 7 positively regulates the TLR4-mediated immune response via its E3 ligase domain in macrophages. Mol Immunol. 2019;109:126–33. https://doi.org/10.1016/j.molimm.2019.01.015.

Article  CAS  PubMed  Google Scholar 

Du Y, Chu CM, Zhuo D, Ning JZ. The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury. Int J Biol Macromol. 2022;209:725–36. https://doi.org/10.1016/j.ijbiomac.2022.04.054.

Article  CAS  PubMed  Google Scholar 

Kalyanaraman B. Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: have we been barking up the wrong tree? Redox Biol. 2020;29:101394. https://doi.org/10.1016/j.redox.2019.101394.

Article  CAS  PubMed  Google Scholar 

Chen Y, Shi S, Dai Y. Research progress of therapeutic drugs for doxorubicin-induced cardiomyopathy. Biomed Pharmacother. 2022;156:113903. https://doi.org/10.1016/j.biopha.2022.113903.

Article  CAS  PubMed  Google Scholar 

Lorenzana-Carrillo MA, Tejay S, Nanoa J, et al. TRIM35 monoubiquitinates H2B in cardiac cells implications for heart failure. Circ Res. 2024. https://doi.org/10.1161/CIRCRESAHA.123.324202.

Article  PubMed  Google Scholar 

Quagliariello V, Vecchione R, Coppola C, et al. Cardioprotective effects of nanoemulsions loaded with anti-inflammatory nutraceuticals against doxorubicin-induced cardiotoxicity. Nutrients. 2018;10. https://doi.org/10.3390/nu10091304.

Liu K, Gu Y, Gu S, et al. Trim27 aggravates airway inflammation and oxidative stress in asthmatic mice via potentiating the NLRP3 inflammasome. Int Immunopharmacol. 2024;134:112199. https://doi.org/10.1016/j.intimp.2024.112199.

Article  CAS  PubMed  Google Scholar 

Luo Q, Jahangir A, He J, et al. Ameliorating effects of TRIM67 against intestinal inflammation and barrier dysfunction induced by high fat diet in obese mice. Int J Mol Sci. 2022;23. https://doi.org/10.3390/ijms23147650.

Ortiz-Fernandez L, Carmona EG, Kerick M, et al. Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing. Ann Rheum Dis. 2023;82:837–47. https://doi.org/10.1136/ard-2022-223697.

Article  CAS  PubMed  Google Scholar 

Sumneang N, Tanajak P, Oo TT. Toll-like receptor 4 inflammatory perspective on doxorubicin-induced cardiotoxicity. Molecules. 2023;28. https://doi.org/10.3390/molecules28114294.

Baniahmad B, Safaeian L, Vaseghi G, Rabbani M, Mohammadi B. Cardioprotective effect of vanillic acid against doxorubicin-induced cardiotoxicity in rat. Res Pharm Sci. 2020;15:87–96. https://doi.org/10.4103/1735-5362.278718.

Article  PubMed  PubMed Central  Google Scholar 

Xu L, Wang C, Zou Z, Wu Z. Ozone attenuated H9c2 cell injury induced by doxorubicin. J Cardiovasc Pharmacol. 2021;78:e86–93. https://doi.org/10.1097/FJC.0000000000001043.

Article  CAS  PubMed  Google Scholar