Acharya MM, Martirosian V, Chmielewski NN, Hanna N, Tran KK, Liao AC, Christie LA, Parihar VK, Limoli CL (2015a) Stem cell transplantation reverses chemotherapy-induced cognitive dysfunction. Cancer Res 75(4):676–686. https://doi.org/10.1158/0008-5472.CAN-14-2237
Article CAS PubMed PubMed Central Google Scholar
Acharya MM, Rosi S, Jopson T, Limoli CL (2015b) Human neural stem cell transplantation provides long-term restoration of neuronal plasticity in the irradiated hippocampus. Cell Transpl 24(4):691–702. https://doi.org/10.3727/096368914X684600
Alaghband Y, Allen BD, Kramar EA, Zhang R, Drayson OGG, Ru N, Petit B, Almeida A, Doan N-L, Wood MA, Baulch JE, Ballesteros-Zebadua P, Vozenin M-C, Limoli CL (2023a) Uncovering the protective neurologic mechanisms of hypofractionated FLASH radiotherapy. Cancer Res Comm 3(4):1–13. https://doi.org/10.1158/2767–9764.CRC-23-0117
Alaghband Y, Klein PM, Kramar EA, Cranston MN, Perry BC, Shelerud LM, Kane AE, Doan NL, Ru N, Acharya MM, Wood MA, Sinclair DA, Dickstein DL, Soltesz I, Limoli CL, Baulch JE (2023b) Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments. Cell Mol Life Sci 80(1):29. https://doi.org/10.1007/s00018-022-04666-8
Article CAS PubMed PubMed Central Google Scholar
Allen BD, Alaghband Y, Kramar EA, Ru N, Petit B, Grilj V, Petronek MS, Pulliam CF, Kim RY, Doan NL, Baulch JE, Wood MA, Bailat C, Spitz DR, Vozenin MC, Limoli CL (2022) Elucidating the neurological mechanism of the FLASH effect in juvenile mice exposed to hypofractionated radiotherapy. Neurooncology. https://doi.org/10.1093/neuonc/noac248
Attardo A, Fitzgerald JE, Schnitzer MJ (2015) Impermanence of dendritic spines in live adult CA1 hippocampus. Nature 523(7562):592–596. https://doi.org/10.1038/nature14467
Article CAS PubMed PubMed Central Google Scholar
Bates D, Mächler M, BM B, Walker S (2015) Fitting linear mixed-effects models using lme4. J Stat Softw 67:1–48
Baulch JE, Acharya MM, Allen BD, Ru N, Chmielewski NN, Martirosian V, Giedzinski E, Syage A, Park AL, Benke SN, Parihar VK, Limoli CL (2016) Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain. Proc Natl Acad Sci U S A 113(17):4836–4841. https://doi.org/10.1073/pnas.1521668113
Article CAS PubMed PubMed Central Google Scholar
Bell BI, Velten C, Pennock M, Kang M, Tanaka KE, Selvaraj B, Bookbinder A, Koba W, Vercellino J, English J, Malachowska B, Pandey S, Duddempudi PK, Yang Y, Shajahan S, Hasan S, Choi JI, Simone CB 2nd, Yang WL, Tome WA, Lin H, Guha C (2024) Whole abdominal pencil beam scanned proton FLASH increases acute lethality. Int J Radiat Oncol Biol Phys. https://doi.org/10.1016/j.ijrobp.2024.09.006
Berry KP, Nedivi E (2017) Spine dynamics: are they all the same?? Neuron 96(1):43–55. https://doi.org/10.1016/j.neuron.2017.08.008
Article CAS PubMed PubMed Central Google Scholar
Bloss EB, Janssen WG, McEwen BS, Morrison JH (2010) Interactive effects of stress and aging on structural plasticity in the prefrontal cortex. J Neurosci 30(19):6726–6731. https://doi.org/10.1523/JNEUROSCI.0759-10.2010
Article CAS PubMed PubMed Central Google Scholar
Bloss E, Morrison J, Hof P, Dickstein D (2011) Influence of aging and neurodegenration on dendritic spine morphology. Translational Neurosceince 2(1):49–60
Bloss EB, Puri R, Yuk F, Punsoni M, Hara Y, Janssen WG, McEwen BS, Morrison JH (2013) Morphological and molecular changes in aging rat prelimbic prefrontal cortical synapses. Neurobiol Aging 34(1):200–210. https://doi.org/10.1016/j.neurobiolaging.2012.05.014
Article CAS PubMed Google Scholar
Chakraborti A, Allen A, Allen B, Rosi S, Fike JR (2012) Cranial irradiation alters dendritic spine density and morphology in the hippocampus. PLoS ONE 7(7):e40844. https://doi.org/10.1371/journal.pone.0040844
Article CAS PubMed PubMed Central Google Scholar
Christie LA, Acharya MM, Parihar VK, Nguyen A, Martirosian V, Limoli CL (2012) Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy. Clin cancer Research: Official J Am Association Cancer Res 18(7):1954–1965. https://doi.org/10.1158/1078-0432.CCR-11-2000
Dickstein DL, Kabaso D, Rocher AB, Luebke JI, Wearne SL, Hof PR (2007) Changes in the structural complexity of the aged brain. Aging Cell 6(3):275–284. https://doi.org/10.1111/j.1474-9726.2007.00289.x
Article CAS PubMed Google Scholar
Dickstein DL, Brautigam H, Stockton SD Jr., Schmeidler J, Hof PR (2010) Changes in dendritic complexity and spine morphology in Transgenic mice expressing human wild-type Tau. Brain Struct Function 214(2–3):161–179. https://doi.org/10.1007/s00429-010-0245-1
Dickstein DL, Weaver CM, Luebke JI, Hof PR (2013) Dendritic spine changes associated with normal aging. Neuroscience 251:21–32. https://doi.org/10.1016/j.neuroscience.2012.09.077
Article CAS PubMed Google Scholar
Dickstein DL, Talty R, Bresnahan E, Varghese M, Perry B, Janssen WGM, Sowa A, Giedzinski E, Apodaca L, Baulch J, Acharya M, Parihar V, Limoli CL (2018) Alterations in synaptic density and myelination in response to exposure to high-energy charged particles. J Comp Neurol 526(17):2845–2855. https://doi.org/10.1002/cne.24530
Article CAS PubMed PubMed Central Google Scholar
Dupree JL, Polak PE, Hensley K, Pelligrino D, Feinstein DL (2015) Lanthionine ketimine ester provides benefit in a mouse model of multiple sclerosis. J Neurochem 134(2):302–314. https://doi.org/10.1111/jnc.13114
Article CAS PubMed Google Scholar
Evenden J (2013) Cognitive impairments and cancer chemotherapy: translational research at a crossroads. Life Sci 93(17):589–595. https://doi.org/10.1016/j.lfs.2013.03.020
Article CAS PubMed Google Scholar
Geinisman Y, deToledo-Morrell L, Morrell F, Heller RE, Rossi M, Parshall RF (1993) Structural synaptic correlate of long-term potentiation: formation of axospinous synapses with multiple, completely partitioned transmission zones. Hippocampus 3(4):435–445. https://doi.org/10.1002/hipo.450030405
Article CAS PubMed Google Scholar
Krishnan B, Natarajan C, Bourne KZ, Alikhani L, Wang J, Sowa A, Groen K, Perry B, Dickstein DL, Baulch JE, Limoli CL, Britten RA (2021) Chronic low dose neutron exposure results in altered neurotransmission properties of the Hippocampus-Prefrontal cortex Axis in both mice and rats. Int J Mol Sci 22(7). https://doi.org/10.3390/ijms22073668
Kuznetsova A, Brockhoff PB, Christensen RHB (2017) LmerTest package: tests in linear mixed effects models. J Stat Softw 82(13):1–26
Lazarczyk MJ, Kemmler JE, Eyford BA, Short JA, Varghese M, Sowa A, Dickstein DR, Yuk FJ, Puri R, Biron KE, Leist M, Jefferies WA, Dickstein DL (2016) Major histocompatibility complex class I proteins are critical for maintaining neuronal structural complexity in the aging brain. Sci Rep 6:26199. https://doi.org/10.1038/srep26199
Article CAS PubMed PubMed Central Google Scholar
Lazarczyk MJ, Eyford BA, Varghese M, Arora H, Munro L, Warda T, Pfeifer CG, Sowa A, Dickstein DR, Rumbell T, Jefferies WA, Dickstein DL (2023) The intracellular domain of major histocompatibility class-I proteins is essential for maintaining excitatory spine density and synaptic ultrastructure in the brain. Sci Rep 13(1):6448. https://doi.org/10.1038/s41598-023-30054-8
Article CAS PubMed PubMed Central Google Scholar
Length RV (2022) emmeans: estimated marginal means, aka least squares means. R package version 1.7.0
Limoli CL, Kramar EA, Almeida A, Petit B, Grilj V, Baulch JE, Ballesteros-Zebadua P, Loo BW Jr., Wood MA, Vozenin MC (2023) The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation. Radiother Oncol 186:109767. https://doi.org/10.1016/j.radonc.2023.109767
Article CAS PubMed PubMed Central Google Scholar
Makale MT, McDonald CR, Hattangadi-Gluth JA, Kesari S (2017) Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours. Nat Reviews Neurol 13(1):52–64. https://doi.org/10.1038/nrneurol.2016.185
Mizumatsu S, Monje M, Morhardt D, Rola R, Palmer T,
Comments (0)