Clinicopathologic and Molecular Analysis of 15 Pediatric and Young Adult Patients with High-Grade Non-anaplastic Thyroid Carcinoma

Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin 2024; 74; 12-49.

Article  PubMed  Google Scholar 

Hardin AP, Hackell JM, Simon GR, et al. Age Limit of Pediatrics. Pediatrics 2017; 140.

Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016; 26; 1-133.

Article  PubMed  PubMed Central  Google Scholar 

Sakamoto A, Kasai N, Sugano H. Poorly differentiated carcinoma of the thyroid. A clinicopathologic entity for a high-risk group of papillary and follicular carcinomas. Cancer 1983; 52; 1849–1855.

Carcangiu ML, Zampi G, Rosai J. Poorly differentiated (‘insular’) thyroid carcinoma. A reinterpretation of Langhans’ ‘wuchernde Struma’. Am J Surg Pathol 1984; 8; 655–668.

WHO Classification of Tumors Editorial Board. Endocrine and Neuroendocrine Tumors. Vol 10. 5th ed. Lyon (France): International Agency for Research on Cancer; 2022.

Xu B, Ibrahimpasic T, Wang L, et al. Clinicopathologic Features of Fatal Non-Anaplastic Follicular Cell-Derived Thyroid Carcinomas. Thyroid 2016; 26; 1588-1597.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Volante M, Collini P, Nikiforov YE, et al. Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach. Am J Surg Pathol 2007; 31; 1256-1264.

Article  PubMed  Google Scholar 

Asioli S, Erickson LA, Righi A, et al. Poorly differentiated carcinoma of the thyroid: validation of the Turin proposal and analysis of IMP3 expression. Mod Pathol 2010; 23; 1269-1278.

Article  PubMed  Google Scholar 

Ibrahimpasic T, Ghossein R, Carlson DL, et al. Outcomes in patients with poorly differentiated thyroid carcinoma. J Clin Endocrinol Metab 2014; 99; 1245-1252.

Article  CAS  PubMed  Google Scholar 

Chernock RD, Rivera B, Borrelli N, et al. Poorly differentiated thyroid carcinoma of childhood and adolescence: a distinct entity characterized by DICER1 mutations. Mod Pathol 2020; 33; 1264-1274.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dettmer M, Schmitt A, Steinert H, et al. Poorly differentiated oncocytic thyroid carcinoma--diagnostic implications and outcome. Histopathology 2012; 60; 1045-1051.

Article  PubMed  Google Scholar 

Bai S, Baloch ZW, Samulski TD, et al. Poorly differentiated oncocytic (hürthle cell) follicular carcinoma: an institutional experience. Endocr Pathol 2015; 26; 164-169.

Article  CAS  PubMed  Google Scholar 

Torous VF, Jitpasutham T, Baloch Z, et al. Cytologic features of differentiated high-grade thyroid carcinoma: A multi-institutional study of 40 cases. Cancer Cytopathol 2024; 132; 525-536.

Article  CAS  PubMed  Google Scholar 

Tondi Resta I, Gubbiotti MA, Montone KT, et al. Differentiated high grade thyroid carcinomas: Diagnostic consideration and clinical features. Hum Pathol 2024; 144; 53-60.

Article  CAS  PubMed  Google Scholar 

Norlén O, Charlton A, Sarkis LM, et al. Risk of malignancy for each Bethesda class in pediatric thyroid nodules. J Pediatr Surg 2015; 50; 1147-1149.

Article  PubMed  Google Scholar 

Coca-Pelaz A, Rodrigo JP, Agaimy A, et al. Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact. Virchows Arch 2024; 484; 733-742.

Article  PubMed  Google Scholar 

Condello V, Roberts JW, Stenman A, et al. Atrophic changes in thyroid tumors are strong indicators of underlying DICER1 mutations: a bi-institutional genotype-phenotype correlation study. Virchows Arch 2024; 485; 105-114.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hassoun AA, Hay ID, Goellner JR, et al. Insular thyroid carcinoma in adolescents: a potentially lethal endocrine malignancy. Cancer 1997; 79; 1044-1048.

Article  CAS  PubMed  Google Scholar 

Gnemmi V, Renaud F, Do Cao C, et al. Poorly differentiated thyroid carcinomas: application of the Turin proposal provides prognostic results similar to those from the assessment of high-grade features. Histopathology 2014; 64; 263-273.

Article  PubMed  Google Scholar 

Hiltzik D, Carlson DL, Tuttle RM, et al. Poorly differentiated thyroid carcinomas defined on the basis of mitosis and necrosis: a clinicopathologic study of 58 patients. Cancer 2006; 106; 1286-1295.

Article  PubMed  Google Scholar 

Lam KY, Lo CY, Chan KW, et al. Insular and anaplastic carcinoma of the thyroid: a 45-year comparative study at a single institution and a review of the significance of p53 and p21. Ann Surg 2000; 231; 329-338.

Article  CAS  PubMed  PubMed Central  Google Scholar 

LiVolsi VA, Abrosimov AA, Bogdanova T, et al. The Chernobyl thyroid cancer experience: pathology. Clin Oncol (R Coll Radiol) 2011; 23; 261-267.

Article  CAS  PubMed  Google Scholar 

Rivera M, Ricarte-Filho J, Patel S, et al. Encapsulated thyroid tumors of follicular cell origin with high grade features (high mitotic rate/tumor necrosis): a clinicopathologic and molecular study. Hum Pathol 2010; 41; 172-180.

Article  CAS  PubMed  Google Scholar 

Slack JC, Hollowell M, Barletta JA. Thyroid Nodules and Follicular Cell-Derived Thyroid Carcinomas in Children. Endocr Pathol 2023; 34; 165-175.

Article  PubMed  Google Scholar 

Saliba M, Alzumaili BA, Katabi N, et al. Clinicopathologic and Prognostic Features of Pediatric Follicular Cell-derived Thyroid Carcinomas: A Retrospective Study of 222 Patients. Am J Surg Pathol 2022; 46; 1659-1669.

Article  PubMed  PubMed Central  Google Scholar 

Tanaka K, Sonoo H, Saito W, et al. Analysis of clinical outcome of patients with poorly differentiated thyroid carcinoma. ISRN Endocrinol 2011; 2011; 308029.

Article  PubMed  PubMed Central  Google Scholar 

Thompson LDR. High Grade Differentiated Follicular Cell-Derived Thyroid Carcinoma Versus Poorly Differentiated Thyroid Carcinoma: A Clinicopathologic Analysis of 41 Cases. Endocr Pathol 2023; 34; 234-246.

Article  CAS  PubMed  Google Scholar 

Volante M, Landolfi S, Chiusa L, et al. Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns: a clinicopathologic study of 183 patients. Cancer 2004; 100; 950-957.

Article  PubMed  Google Scholar 

Wong KS, Lorch JH, Alexander EK, et al. Prognostic Significance of Extent of Invasion in Poorly Differentiated Thyroid Carcinoma. Thyroid 2019; 29; 1255-1261.

Article  PubMed  Google Scholar 

Wong KS, Dong F, Telatar M, et al. Papillary Thyroid Carcinoma with High-Grade Features Versus Poorly Differentiated Thyroid Carcinoma: An Analysis of Clinicopathologic and Molecular Features and Outcome. Thyroid 2021; 31; 933-940.

Article  CAS  PubMed  Google Scholar 

Xu B, David J, Dogan S, et al. Primary high-grade non-anaplastic thyroid carcinoma: a retrospective study of 364 cases. Histopathology 2022; 80; 322-337.

Article  PubMed  Google Scholar 

Gallant J-N, Chen S-C, Ortega CA, et al. Evaluation of the Molecular Landscape of Pediatric Thyroid Nodules and Use of a Multigene Genomic Classifier in Children. JAMA Oncol 2022; 8; 1323-1327.

Article  PubMed  PubMed Central  Google Scholar 

Yegen G, Altay AY, Yılmaz İ, et al. DICER1 Mutations Do Not Always Indicate Dismal Prognosis in Pediatric Poorly Differentiated Thyroid Carcinomas. Endocr Pathol 2023; 34; 279-286.

Article  CAS  PubMed  Google Scholar 

Ghossein CA, Dogan S, Farhat N, et al. Expanding the spectrum of thyroid carcinoma with somatic DICER1 mutation: a survey of 829 thyroid carcinomas using MSK-IMPACT next-generation sequencing platform. Virchows Arch 2022; 480; 293-302.

Article  CAS  PubMed 

Comments (0)

No login
gif