Rindi G, Mete O, Uccella S, Basturk O, La Rosa S, Brosens LAA, Ezzat S, de Herder W W, Klimstra DS, Papotti M, Asa SL (2022) Overview of the 2022 WHO Classification of Neuroendocrine Neoplasms. Endocrine Pathology 33, 115-154. https://doi.org/10.1007/s12022-022-09708-2.

Article  CAS  PubMed  Google Scholar 

Mete O, Wenig BM (2022) Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms. Head Neck Pathol 16 123–142. https://doi.org/10.1007/s12105-022-01435-8.

Uccella S, La Rosa S, Metovic J, Marchiori D, Scoazec JY, Volante M, Mete O, Papotti M (2021) Genomics of High-Grade Neuroendocrine Neoplasms: Well-Differentiated Neuroendocrine Tumor with High-Grade Features (G3 NET) and Neuroendocrine Carcinomas (NEC) of Various Anatomic Sites. Endocr Pathol 32, 192-210. https://doi.org/10.1007/s12022-020-09660-z.

Article  PubMed  Google Scholar 

Sturgis CD, Burkey BB, Momin S, Hoschar AP (2015) High Grade (Large Cell) Neuroendocrine Carcinoma of the Nasopharynx: Novel Case Report with Touch Preparation Cytology and Positive EBV Encoded Early RNA. Case Reports in Pathology 2015, 1-4. https://doi.org/10.1155/2015/231070.

Article  Google Scholar 

Wasserman JK, Papp S, Hope AJ, Perez-Ordóñez B (2018) Epstein-Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of a Case with Complete Clinical and Radiological Response After Combined Chemoradiotherapy. Head and Neck Pathology 12, 587-591. https://doi.org/10.1007/s12105-017-0883-1.

Article  PubMed  PubMed Central  Google Scholar 

Cai Z, Lin M, Blanco AI, Liu J, Zhu H (2018) Epstein–Barr Virus-Positive Large Cell Neuroendocrine Carcinoma of the Nasopharynx: Report of One Case and Review of the Literature. Head and Neck Pathology 13, 313-317. https://doi.org/10.1007/s12105-018-0963-x.

Article  PubMed  PubMed Central  Google Scholar 

Prantesh J, Dorth J, Asa SL, Mohamed A (2021) Nasopharyngeal neuroendocrine neoplasms: Systematic review of the literature and case presentation. J Neuroendocrinol 33, e13005. https://doi.org/10.1111/jne.13005.

Su Z, Yan H, Zou G (2022) EBV‑positive large‑cell and small‑cell neuroendocrine carcinoma of the nasopharynx: A case report and review of the literature. Oncology Letters 24. https://doi.org/10.3892/ol.2022.13584.

Lin YW, Ting CH, Chen TY, Leu YS (2022) Nasopharyngeal Large Cell Neuroendocrine Carcinoma Synchronized With Nasopharyngeal Squamous Cell Carcinoma: A Case Report and Review of Literature. Ear Nose Throat J 1455613221138210. https://doi.org/10.1177/01455613221138210.

Chen Y, Zhou N, Huang C, He X, Wang X, Tang H, Wang W, Wang J, Li T, Guo D (2024) EBV-positive small cell neuroendocrine carcinoma of nasopharynx as a probably unique subtype of neuroendocrine carcinoma: a clinicopathologic study of three cases and literature review. Diagn Pathol 19, 101. https://doi.org/10.1186/s13000-024-01526-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan CZ, Li HN, Dai LJ, Li Z (2024) [Epstein-Barr virus-positive small cell neuroendocrine carcinoma of the nasopharynx: report of a case]. Zhonghua Bing Li Xue Za Zhi 53, 86-88. https://doi.org/10.3760/cma.j.cn112151-20230901-00117.

Huang Y, Xie J, Ding Y, Zhou X (2016) Extranodal Natural Killer/T-Cell Lymphoma in Children and Adolescents: A Report of 17 Cases in China. Am J Clin Pathol, 145, 46-54. https://doi.org/10.1093/ajcp/aqv010.

Article  PubMed  Google Scholar 

Li H, Durbin R (2009) Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics, 25, 1754-60. https://doi.org/10.1093/bioinformatics/btp324.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A, Garimella K, Altshuler D, Gabriel S, Daly M, DePristo MA (2010) The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res 20, 1297-303. https://doi.org/10.1101/gr.107524.110.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koboldt DC, Zhang Q, Larson DE, Shen D, McLellan MD, Lin L, Miller CA, Mardis E R, Ding L, Wilson RK (2012) VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing, Genome Res. 22, 568-76. https://doi.org/10.1101/gr.129684.111.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang K, Li M, Hakonarson H (2010) ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 38, e164. https://doi.org/10.1093/nar/gkq603.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cingolani P, Platts A, Wang le L, Coon M, Nguyen T, Wang L, Land SJ, Lu X, Ruden DM (2012) A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin) 6, 80-92. https://doi.org/10.4161/fly.19695.

Newman AM, Bratman SV, Stehr H, Lee LJ, Liu CL, Diehn M, Alizadeh AA (2014) FACTERA: a practical method for the discovery of genomic rearrangements at breakpoint resolution. Bioinformatics 30, 3390-3. https://doi.org/10.1093/bioinformatics/btu549.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Uccella S (2024) Molecular Classification of Gastrointestinal and Pancreatic Neuroendocrine Neoplasms: Are We Ready for That?. Endocrine Pathology 35, 91-106. https://doi.org/10.1007/s12022-024-09807-2.

Article  PubMed  PubMed Central  Google Scholar 

Venizelos A, Elvebakken H, Perren A, Nikolaienko O, Deng W, Lothe IMB, Couvelard A, Hjortland GO, Sundlov A, Svensson J, Garresori H, Kersten C, Hofsli E, Detlefsen S, Krogh M, Sorbye H, Knappskog S (2021) The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms. Endocr Relat Cancer 29, 1-14. https://doi.org/10.1530/ERC-21-0152.

Article  PubMed  PubMed Central  Google Scholar 

Rekhtman N, Pietanza MC, Hellmann MD, Naidoo J, Arora A, Won H, Halpenny DF, Wang H, Tian SK, Litvak AM, Paik PK, Drilon AE, Socci N, Poirier JT, Shen R, Berger MF, Moreira AL, Travis WD, Rudin CM, Ladanyi M (2016) Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets. Clin Cancer Res 22, 3618-29. https://doi.org/10.1158/1078-0432.CCR-15-2946.

Article  CAS  PubMed  PubMed Central  Google Scholar 

George J, Lim JS, Jang SJ et al (2015) Comprehensive genomic profiles of small cell lung cancer. Nature 524, 47-53. https://doi.org/10.1038/nature14664.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alos L, Hakim S, Larque AB, de la Oliva J, Rodriguez-Carunchio L, Caballero M, Nadal A, Marti C, Guimera N, Fernandez-Figueras MT, Quint W, Ordi J (2016) p16 overexpression in high-grade neuroendocrine carcinomas of the head and neck: potential diagnostic pitfall with HPV-related carcinomas. Virchows Arch 469, 277-84. https://doi.org/10.1007/s00428-016-1982-1.

Article  CAS  PubMed  Google Scholar 

Kao HL, Chang WC, Li WY, Chia-Heng Li A, Fen-Yau Li A (2012) Head and neck large cell neuroendocrine carcinoma should be separated from atypical carcinoid on the basis of different clinical features, overall survival, and pathogenesis. Am J Surg Pathol 36, 185-92. https://doi.org/10.1097/PAS.0b013e318236d822.

Article  PubMed  Google Scholar 

Banerjee J, Ranjan RP, Alam MT, Deshmukh S, Tripathi PP, Gandhi S, Banerjee S (2023) Virus-associated neuroendocrine cancers: Pathogenesis and current therapeutics. Pathol Res Pract 248, 154720. https://doi.org/10.1016/j.prp.2023.154720.

Article  CAS  PubMed  Google Scholar 

Chokwassanasakulkit T, McMillan NAJ. (2024) Merkel Cell Polyomavirus-Pathophysiology and Treatment in the Era of Gene-Targeted Therapies. Rev Med Virol 34, e2580. https://doi.org/10.1002/rmv.2580.

Article  CAS  PubMed  Google Scholar 

Feng H, Shuda M, Chang Y, Moore PS (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319, 1096-100. https://doi.org/10.1126/science.1152586.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng, H., Kwun, H. J., Liu, X., Gjoerup, O., Stolz, D. B., Chang, Y. & Moore, P. S. (2011) Cellular and viral factors regulating Merkel cell polyomavirus replication. PLoS One 6, e22468. https://doi.org/10.1371/journal.pone.0022468.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong S, Liu D, Luo S, Fang W, Zhan J, Fu S, Zhang Y, Wu X, Zhou H, Chen X, Chen G, Zhang Z, Zheng Q, Li X, Chen J, Liu X, Lei M, Ye C, Wang J, Yang H, Xu X, Zhu S, Yang Y, Zhao Y, Zhou N, Zhao H, Huang Y, Zhang L, Wu K, Zhang L (2019) The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma. Nat Commun 10, 3108. https://doi.org/10.1038/s41467-019-10902-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Deng Y, Huang Y, Ye J, Xie S, He Q, Chen Y, Lin Y, Liang R, Wei J, Li Y, Zhang J (2022) Nasopharyngeal Carcinoma Progression: Accumulating Genomic Instability and Persistent Epstein-Barr Virus Infection. Curr Oncol, 29, 6035-6052. https://doi.org/10.3390/curroncol29090475.

Article