Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway

China Pharmacopoeia Committee (2020) Pharmacopoeia of the People’s Republic of China: Volume I. China Medical Science Press, Beijing, p 172

Google Scholar 

He X, Wang J, Li M et al (2014) Eucommia ulmoides Oliv.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. J Ethnopharmacol 151(1):78–92

Article  PubMed  Google Scholar 

Wang T, Fan L, Feng S et al (2022) Network pharmacology of iridoid glycosides from Eucommia ulmoides oliver against osteoporosis. Sci Rep 12(1):7430

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mills KT, Xu Y, Zhang W et al (2015) A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010. Kidney Int 88(5):950–957

Article  PubMed  PubMed Central  Google Scholar 

Zhang Y, Wang S, Liu S et al (2015) Role of Smad signaling in kidney disease. Int Urol Nephrol 47:1965–1975

Article  CAS  PubMed  Google Scholar 

Li R, Guo Y, Zhang Y et al (2019) Salidroside ameliorates renal interstitial fibrosis by inhibiting the TLR4/NF-κB and MAPK signaling pathways. Int J Mol Sci 20(5):1103

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeisberg M, Neilson EG (2010) Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 21(11):1819–1834

Article  CAS  PubMed  Google Scholar 

Tian F, Wang Z, He J et al (2020) 4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species. Eur J Pharmacol 873:172989

Article  CAS  PubMed  Google Scholar 

Li Q, Tu J, Zhou B (2019) The tannins from Punica granatum L., natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo. J Funct Foods 57:361–372

Article  CAS  Google Scholar 

Wan YG, Che XY, Sun W et al (2014) Low-dose of multi-glycoside of Tripterygium wilfordii Hook. F., a natural regulator of TGF-β1/Smad signaling activity improves adriamycin-induced glomerulosclerosis in vivo. J Ethnopharmacol 151(3):1079–1089

Article  CAS  PubMed  Google Scholar 

Liu W (2014) Effects of kidney tonic and antihypertensive formula on TGF β/Smads signaling pathway associated with renal damage in salt-sensitive hypertensive rats. Beijing University of Chinese Medicine, Beijing

Google Scholar 

Cheng H, Song EF (2009) Effects of Eucommia on TGF-β1/Smad signaling pathway in renal interstitial fibrosis in rats with unilateral ureteral obstruction. Chin J Integr Tradit West Nephrol 10(06):502–504+566

Diwan V, Brown L, Gobe GC (2018) Adenine-induced chronic kidney disease in rats. Nephrology 23(1):5–11

Article  CAS  PubMed  Google Scholar 

Liu SF, Chang SY, Lee TC et al (2012) Dioscorea alata attenuates renal interstitial cellular fibrosis by regulating Smad-and epithelial-mesenchymal transition signaling pathways. PLoS ONE 7(11):e47482

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zou J, Zhou X, Ma Y et al (2022) Losartan ameliorates renal interstitial fibrosis through metabolic pathway and Smurfs-TGF-β/Smad. Biomed Pharmacother 149:112931

Article  CAS  PubMed  Google Scholar 

Hu B, Wu Z, Phan SH (2003) Smad3 mediates transforming growth factor-β-induced α-smooth muscle actin expression. Am J Respir Cell Mol Biol 29(3):397–404

Article  CAS  PubMed  Google Scholar 

Li J, Qu X, Bertram JF (2009) Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice. Am J Pathol 175(4):1380–1388

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu S, Zhao J, Tian W et al (2022) Estrogen deficiency aggravates fluorine ion-induced renal fibrosis via the TGF-β1/Smad signaling pathway in rats. Toxicol Lett 362:26–37

Article  CAS  PubMed  Google Scholar 

Hu HH, Chen DQ, Wang YN et al (2018) New insights into TGF-β/Smad signaling in tissue fibrosis. Chem Biol Interact 292:76–83

Article  CAS  PubMed  Google Scholar 

Zhao M, Yang B, Li L et al (2022) Efficacy of modified Huangqi Chifeng decoction in alleviating renal fibrosis in rats with IgA nephropathy by inhibiting the TGF-β1/Smad3 signaling pathway through exosome regulation. J Ethnopharmacol 285:114795

Article  CAS  PubMed  Google Scholar 

Gao J, Liu JQ, Hu JX et al (2023) Effects of Huangqi Sangye Yuzhu granules on early renal injury and TGF-β1/P-Smad3/P-Smad7signaling pathway in hyperglycemia rats with qi and yin deficiency syndrome. Jilin J Chin Med 43(09):1068–1073

Google Scholar 

Isaka Y (2018) Targeting TGF-β signaling in kidney fibrosis. Int J Mol Sci 19(9):2532

Article  PubMed  PubMed Central  Google Scholar 

Yuan Q, Tang B, Zhang C (2022) Signaling pathways of chronic kidney diseases, implications for therapeutics. Signal Transduct Target Ther 7(1):182

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian X, Zeng Y, Tu Q et al (2023) Butyrate alleviates renal fibrosis in CKD by regulating NLRP3-mediated pyroptosis via the STING/NF-κB/p65 pathway. Int Immunopharmacol 124:111010

Article  CAS  PubMed  Google Scholar 

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