Altschul SF, Gish W, Miller W et al (1990) Basic local alignment search tool. J Mol Biol 215:403–410. https://doi.org/10.1016/S0022-2836(05)80360-2

Article  PubMed  CAS  Google Scholar 

Amoui M, Craddock BP, Miller WT (2001) Differential phosphorylation of IRS-1 by insulin and insulin-like growth factor I receptors in Chinese hamster ovary cells. J Endocrinol 171:153–162. https://doi.org/10.1677/JOE.0.1710153

Article  PubMed  CAS  Google Scholar 

Anderberg RH, Richard JE, Hansson C et al (2016) GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality. Psychoneuroendocrinology 65:54–66. https://doi.org/10.1016/J.PSYNEUEN.2015.11.021

Article  PubMed  CAS  Google Scholar 

Aoki R, Onuki M, Hattori K et al (2021) Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice. Microbiome 9:1–16. https://doi.org/10.1186/S40168-021-01125-7/FIGURES/7

Article  Google Scholar 

Barbagallo M, Dominguez LJ (2014) Type 2 diabetes mellitus and Alzheimer’s disease. World J Diabetes 5:889. https://doi.org/10.4239/WJD.V5.I6.889

Article  PubMed  PubMed Central  Google Scholar 

Batista AF, Bodart-Santos V, De Felice FG, Ferreira ST (2019) Neuroprotective actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer’s and Parkinson’s diseases. CNS Drugs 33:209–223. https://doi.org/10.1007/S40263-018-0593-6

Article  PubMed  Google Scholar 

Beutler B (2000) Tlr4: central component of the sole mammalian LPS sensor. Curr Opin Immunol 12:20–26

Article  PubMed  CAS  Google Scholar 

Biosa A, Outeiro TF, Bubacco L, Bisaglia M (2018) Diabetes Mellitus as a risk factor for Parkinson’s Disease: a Molecular Point of View. Mol Neurobiol 55:8754–8763. https://doi.org/10.1007/S12035-018-1025-9/FIGURES/3

Article  PubMed  CAS  Google Scholar 

Bird CM, Burgess N (2008) The hippocampus and memory: insights from spatial processing. Nat Rev Neurosci 9:182–194

Article  PubMed  CAS  Google Scholar 

Bleakman D, Alt A, Witkin JM (2008) AMPA receptors in the Therapeutic Management of Depression. CNS Neurol Disord Drug Targets 6:117–126. https://doi.org/10.2174/187152707780363258

Article  Google Scholar 

Bo TB, Zhang XY, Kohl KD et al (2020) Coprophagy prevention alters microbiome, metabolism, neurochemistry, and cognitive behavior in a small mammal. The ISME Journal 2020 14:10 14:2625–2645. https://doi.org/10.1038/s41396-020-0711-6

Bomfim TR, Forny-Germano L, Sathler LB et al (2012) An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers. J Clin Invest 122:1339–1353. https://doi.org/10.1172/JCI57256

Article  PubMed  PubMed Central  CAS  Google Scholar 

Can A, Dao DT, Terrillion CE et al (2012) The tail suspension test. J Vis Exp 3769. https://doi.org/10.3791/3769

Caporaso JG, Lauber CL, Walters WA et al (2012) Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms. The ISME Journal 2012 6:8 6:1621–1624. https://doi.org/10.1038/ismej.2012.8

Caturano A, Acierno C, Nevola R et al (2021) Non-alcoholic fatty liver disease: from pathogenesis to clinical impact. Processes 2021(9):Page135–9135. https://doi.org/10.3390/PR9010135

Article  Google Scholar 

Chireh B, Li M, D’Arcy C (2019) Diabetes increases the risk of depression: a systematic review, meta-analysis and estimates of population attributable fractions based on prospective studies. Prev Med Rep 14:100822. https://doi.org/10.1016/J.PMEDR.2019.100822

Article  PubMed  PubMed Central  Google Scholar 

Chiu YJ, Tu HH, Kung ML et al (2021) Fluoxetine ameliorates high-fat diet-induced metabolic abnormalities partially via reduced adipose triglyceride lipase-mediated adipocyte lipolysis. Biomed Pharmacotherapy 141:111848. https://doi.org/10.1016/j.biopha.2021.111848

Article  CAS  Google Scholar 

Christoff AP, Fernanda A, Sereia R et al (2017) White Paper: bacterial NGS sequencing Neoprospecta Microbiome Technologies Bacterial identification through accurate library preparation and high-throughput sequencing. White Paper: Bacterial NGS Sequencing Bacterial 1:1–5

Google Scholar 

Costello DA, Claret M, Al-Qassab H et al (2012) Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity. PLoS ONE 7. https://doi.org/10.1371/JOURNAL.PONE.0031124

Craciun CI, Neag MA, Catinean A et al (2022) The relationships between Gut Microbiota and Diabetes Mellitus, and treatments for diabetes Mellitus. https://doi.org/10.3390/BIOMEDICINES10020308. Biomedicines 10:

Das R, Emon MPZ, Shahriar M et al (2021) Higher levels of serum IL-1β and TNF-α are associated with an increased probability of major depressive disorder. Psychiatry Res 295. https://doi.org/10.1016/J.PSYCHRES.2020.113568

De MagalhÃes DA, Kume WT, Correia FS et al (2019) High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal. Acad Bras Cienc 91:e20180314. https://doi.org/10.1590/0001-3765201920180314

Article  CAS  Google Scholar 

De Pablo-Fernandez E, Goldacre R, Pakpoor J et al (2018) Association between diabetes and subsequent Parkinson disease: a record-linkage cohort study. Neurology 91:e139–e142. https://doi.org/10.1212/WNL.0000000000005771

Article  PubMed  Google Scholar 

de Paiva IHR, da Silva RS, Mendonça IP et al (2023) Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) improve Neuroinflammation and Cognition by Up-regulating IRS/PI3K/AKT signaling pathway in Diet-induced obese mice. J Neuroimmune Pharmacol 1:1–21. https://doi.org/10.1007/S11481-023-10069-8/FIGURES/13

Article  Google Scholar 

Detka J, Kurek A, Basta-Kaim A et al (2013) Neuroendocrine link between stress, depression and diabetes. Pharmacol Rep 65:1591–1600. https://doi.org/10.1016/S1734-1140(13)71520-2

Article  PubMed  CAS  Google Scholar 

Ding QY, Tian JX, Li M et al (2020) Interactions between therapeutics for metabolic Disease, Cardiovascular Risk factors, and gut microbiota. Front Cell Infect Microbiol 10:530160. https://doi.org/10.3389/FCIMB.2020.530160/BIBTEX

Article  PubMed  PubMed Central  CAS  Google Scholar 

Duan X, Zhang L, Liao Y et al (2024) Semaglutide alleviates gut microbiota dysbiosis induced by a high-fat diet. Eur J Pharmacol 969:176440. https://doi.org/10.1016/j.ejphar.2024.176440

Article  PubMed  CAS  Google Scholar 

Felger JC, Lotrich FE (2013) Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications. Neuroscience

Feng S, Shi T, Qiu J et al (2017) Notch1 deficiency in postnatal neural progenitor cells in the dentate gyrus leads to emotional and cognitive impairment. FASEB J 31:4347–4358. https://doi.org/10.1096/FJ.201700216RR

Article  PubMed  CAS  Google Scholar 

Figueroa-Hall LK, Paulus MP, Savitz J (2020) Toll-like receptor signaling in Depression. Psychoneuroendocrinology 121:104843. https://doi.org/10.1016/J.PSYNEUEN.2020.104843

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fonseca VA, Zinman B, Nauck MA et al (2010) Confronting the type 2 diabetes epidemic: the emerging role of Incretin-based therapies. Am J Med 123:S2–S10. https://doi.org/10.1016/j.amjmed.2010.04.002

Article  PubMed  Google Scholar 

Galicia-Garcia U, Benito-Vicente A, Jebari S et al (2020) Pathophysiology of type 2 diabetes Mellitus. Int J Mol Sci 21:1–34. https://doi.org/10.3390/IJMS21176275

Article  Google Scholar 

Gault VA, Hölscher C (2018) GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes. Peptides (NY) 100:101–107. https://doi.org/10.1016/J.PEPTIDES.2017.11.017

Article  CAS  Google Scholar 

Gouveia A Jr, Lucas Afonseca T, Maximino C et al (2008) Influence of gender and estrous cycle in the forced swim test in rats. Psychol Neurosci 1:191–197. https://doi.org/10.3922/j.psns.2008.2.012

Article  Google Scholar 

Goyal; Rajeev S, Mayank J, Ishwarlal (2023) Type 2 diabetes. Exerc Manage Referred Med Conditions 223–252. https://doi.org/10.4324/9781315102399-12

Hamon M, Blier P (2013) Monoamine neurocircuitry in depression and strategies for new treatments. Prog Neuropsychopharmacol Biol Psychiatry 45:54–63. https://doi.org/10.1016/J.PNPBP.2013.04.009

Article  PubMed  CAS  Google Scholar 

Hasan B, Nayfeh T, Alzuabi M et al (2020) Weight loss and serum lipids in overweight and obese adults: a systematic review and Meta-analysis. J Clin Endocrinol Metab 105. https://doi.org/10.1210/CLINEM/DGAA673

He Q, Babcook MA, Shukla S et al (2016) Obesity-initiated metabolic syndrome promotes urinary voiding dysfunction in a mouse model. Prostate 76:964–976. https://doi.org/10.1002/PROS.23185

Article  PubMed  PubMed Central  CAS