Research progress on the therapeutic effects of nanoparticles loaded with drugs against atherosclerosis

Yusuf S, Joseph P, Rangarajan S, et al. Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study. Lancet. 2020;395(10226):795–808.

Article  PubMed  Google Scholar 

Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med. 1999;340(2):115-126.

Herrington W, Lacey B, Sherliker P, et al. Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease. Circ Res. 2016;118(4):535–46.

Article  CAS  PubMed  Google Scholar 

Xu H, Jiang J, Chen W, et al. Vascular Macrophages in Atherosclerosis. J Immunol Res. 2019;2019:1–14.

Google Scholar 

Bäck M, Yurdagul A, Tabas I, et al. Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities. Nature Rev Cardiol. 2019;16(7):389–406. https://doi.org/10.1038/s41569-019-0169-2.

Ali AH, Younis N, Abdallah R, et al. Lipid-lowering therapies for atherosclerosis: statins, fibrates, ezetimibe and PCSK9 monoclonal antibodies. Current Med Chem. 2021;28(36):7427–45.

Article  CAS  Google Scholar 

Poznyak AV, Wu W-K, Melnichenko AA, et al. Signaling pathways and key genes involved in regulation of foam cell formation in atherosclerosis. Cells. 2020;9(3):584.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473(7347):317–25. https://doi.org/10.1038/nature10146.

Prilepskii AY, Serov NS, Kladko DV, et al. Nanoparticle-based approaches towards the treatment of atherosclerosis. Pharmaceutics. 2020;12(11):1056.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baetke SC, Lammers T, Kiessling F. Applications of nanoparticles for diagnosis and therapy of cancer. British J Radiol. 2015;88(1054):20150207.

Article  CAS  Google Scholar 

Flores AM, Ye J, Jarr K-U, et al. Nanoparticle therapy for vascular diseases. Arteriosclerosis, Thrombosis Vasc Biol. 2019;39(4):635–46.

Article  CAS  Google Scholar 

Lobatto ME, Fuster V, Fayad ZA, et al. Perspectives and opportunities for nanomedicine in the management of atherosclerosis. Nat Rev Drug Discovery. 2011;10(11):835–52. https://doi.org/10.1038/nrd3578.

DiStasio N, Lehoux S, Khademhosseini A, et al. The multifaceted uses and therapeutic advantages of nanoparticles for atherosclerosis research. Materials. 2018;11(5):754.

Article  PubMed  PubMed Central  Google Scholar 

Behera S, Pramanik K, Nayak M. Recent advancement in the treatment of cardiovascular diseases: conventional therapy to nanotechnology. Current Pharmaceut Design. 2015;21(30):4479–97.

Article  CAS  Google Scholar 

Shen Y, Liang L, Zhang S, et al. Organelle-targeting surface-enhanced Raman scattering (SERS) nanosensors for subcellular pH sensing. Nanoscale. 2018;10(4):1622–30.

Article  CAS  PubMed  Google Scholar 

Leal BH, Velasco B, Cambón A, et al. Combined therapeutics for atherosclerosis treatment using polymeric nanovectors. Pharmaceutics. 2022;14(2):258.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao C, Huang Q, Liu C, et al. Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines. Nat Commun. 2020;11(1):2622. https://doi.org/10.1038/s41467-020-16439-7.

Jiang C, Qi Z, Tang Y, et al. Rational design of lovastatin-loaded spherical reconstituted high density lipoprotein for efficient and safe anti-atherosclerotic therapy. Mol Pharmaceut. 2019;16(7):3284–91.

Article  CAS  Google Scholar 

Wei B, Li Y, Ao M, et al. Ganglioside GM3-functionalized reconstituted high-density lipoprotein (GM3-rHDL) as a novel nanocarrier enhances antiatherosclerotic efficacy of statins in apoE−/− C57BL/6 Mice. Pharmaceutics. 2022;14(11):2534.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang C, Qi Z, He W, et al. Dynamically enhancing plaque targeting via a positive feedback loop using multifunctional biomimetic nanoparticles for plaque regression. J Controlled Release. 2019;308:71–85.

Article  CAS  Google Scholar 

Sun Y, Chen L, Zhao S, et al. Effects of nanoparticle-mediated delivery of pitavastatin on atherosclerotic plaques in ApoE-knockout mice and THP-1-derived macrophages. Exp Ther Med. 2020;19(6):3787–97.

CAS  PubMed  PubMed Central  Google Scholar 

Rakshit M, Darwitan A, Muktabar A, et al. Anti-inflammatory potential of simvastatin loaded nanoliposomes in 2D and 3D foam cell models. Nanomed: Nanotechnol, Biol Med. 2021;37:102434.

Article  CAS  Google Scholar 

Imanparast F, Faramarzi MA, Vatannejad A, et al. mZD7349 peptide-conjugated PLGA nanoparticles directed against VCAM-1 for targeted delivery of simvastatin to restore dysfunctional HUVECs. Microvasc Res. 2017;112:14–9.

Article  CAS  PubMed  Google Scholar 

Pham LM, Kim E-C, Ou W, et al. Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis. Biomaterials. 2021;269:120677.

Article  CAS  PubMed  Google Scholar 

Chen L, Wang C, Wu Y. Cholesterol (Blood lipid) lowering potential of Rosuvastatin chitosan nanoparticles for atherosclerosis: preclinical study in rabbit model. Acta Biochim Pol. 2020;67(4):495–9.

CAS  PubMed  Google Scholar 

Saraogi GK, Tholiya S, Mishra Y, et al. Formulation development and evaluation of pravastatin-loaded nanogel for hyperlipidemia management. Gels. 2022;8(2):81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

du Toit LC, Hulisani Demana P, Essop CY. A nano-enabled biotinylated anti-LDL theranostic system to modulate systemic LDL cholesterol. Int J Pharmaceut. 2022;628:122258.

Article  Google Scholar 

Chen F, Chen J, Han C, et al. Theranostics of atherosclerosis by the indole molecule-templated self-assembly of probucol nanoparticles. J Mater Chem B. 2021;9(20):4134–42.

Article  CAS  PubMed  Google Scholar 

Liang X, Li H, Zhang A, et al. Red blood cell biomimetic nanoparticle with anti-inflammatory, anti-oxidative and hypolipidemia effect ameliorated atherosclerosis therapy. Nanomed: Nanotechnol Biol Med. 2022;41:102519.

Article  CAS  Google Scholar 

Chen L, Yang J, Fu X, et al. A targeting mesoporous dopamine nanodrug platform with NIR responsiveness for atherosclerosis improvement. Biomater Adv. 2022;136:212775.

Article  CAS  PubMed  Google Scholar 

Fu X, Yu X, Jiang J, et al. Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis. Nat Commun. 2022;13(1):6528. https://doi.org/10.1038/s41467-022-34248-y.

Bulgarelli A, Martins Dias AA, Caramelli B, et al. Treatment with methotrexate inhibits atherogenesis in cholesterol-fed rabbits. J Cardiovasc Pharmacol. 2012;59(4):308–14. https://doi.org/10.1097/FJC.0b013e318241c385.

You S, Guo X, Xue X, et al. PCSK9 Hapten multicopy displayed onto carrier protein nanoparticle: an antiatherosclerosis vaccine. ACS Biomater Sci Eng. 2019;5(9):4263–71.

Article  CAS  PubMed  Google Scholar 

Satny M, Hubacek JA, Vrablik M. Statins and inflammation. Curr Atheroscler Rep. 2021;23(12):80. https://doi.org/10.1007/s11883-021-00977-6.

Valanti E, Tsompanidis A, Sanoudou D. Pharmacogenomics in the development and characterization of atheroprotective drugs. Methods Mol Biol. 2014;1175:259–300. https://doi.org/10.1007/978-1-4939-0956-8_11.

Duivenvoorden R, Tang J, Cormode DP, et al. A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation. Nat Commun. 2014;5(1):3065. https://doi.org/10.1038/ncomms4065.

Koga J-i, Matoba T, Egashira K. Anti-inflammatory nanoparticle for prevention of atherosclerotic vascular diseases. J Atherosclerosis Thrombosis. 2016;23(7):757–65.

Article  CAS  Google Scholar 

Roberts WC. The rule of 5 and the rule of 7 in lipid-lowering by statin drugs. Am J Cardiol. 1997;80(1):106–7.

Article  CAS  PubMed  Google Scholar 

Laufs U, Scharnagl H, März W. Statin intolerance. Curr Opin Lipidol. 2015;26(6):492–501.

Article  CAS  PubMed  Google Scholar 

Nenna A, Nappi F, Larobina D, et al. Polymers and nanoparticles for statin delivery: current use and future perspectives in cardiovascular disease. Polymers. 2021;13(5):711.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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