Zhong YM, Tong F, Shen J. Lympho-vascular invasion impacts the prognosis in breast-conserving surgery: a systematic review and meta-analysis. BMC Cancer. 2022;22(1):102.

Article  PubMed  PubMed Central  Google Scholar 

Qin L, Heng Y, Deng S, et al. Perineural invasion affects prognosis of patients undergoing colorectal cancer surgery: a propensity score matching analysis. BMC Cancer. 2023;23(1):452.

Article  PubMed  PubMed Central  Google Scholar 

Liu W, Ren S, Zeng C, Hu Y. Prognostic value of perineural invasion in resected non-small cell lung cancer: a meta-analysis. Heliyon. 2023;9(4):e15266.

Article  PubMed  PubMed Central  Google Scholar 

Mollberg NM, Bennette C, Howell E, et al. Lymphovascular invasion as a prognostic indicator in stage I non-small cell lung cancer: a systematic review and meta-analysis. Ann Thorac Surg. 2014;97(3):965–71.

Article  PubMed  Google Scholar 

Li P, He H-Q, Zhu C-M, et al. The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China. BMC Cancer. 2015;15:1–10.

Google Scholar 

Li C, Wang M, Cheng X, Jiang Y, Xiao H. Nerve invasion as an independent predictor of poor prognosis in gastric cancer after curative resection. Medicine (Baltimore). 2022;101(33):e30084.

Article  CAS  PubMed  Google Scholar 

Xu Y, Chen Q, Yu X, et al. Factors influencing the risk of recurrence in patients with esophageal carcinoma treated with surgery: a single institution analysis consisting of 1002 cases. Oncol Lett. 2013;5(1):185–90.

Article  PubMed  Google Scholar 

Kurokawa T, Hamai Y, Emi M, Ibuki Y, Okada M. Risk factors for recurrence in esophageal squamous cell carcinoma without pathological complete response after trimodal therapy. Anticancer Res. 2020;40(8):4387–94.

Article  CAS  PubMed  Google Scholar 

Chou, Teh-Ying, Wang, et al. Lymphovascular invasion and extracapsular invasion are risk factors for distant recurrence after preoperative chemoradiotherapy and oesophagectomy in patients with oesophageal squamous cell carcinoma. Eur J Cardio Thoracic Surg. 2017;51(6):1188–94.

Chen JW, Xie JD, Ling YH, et al. The prognostic effect of perineural invasion in esophageal squamous cell carcinoma. BMC Cancer. 2014;14(1):313.

Article  PubMed  PubMed Central  Google Scholar 

Arnold M, Soerjomataram I, Ferlay J, Forman D. Global incidence of oesophageal cancer by histological subtype in 2012. Gut. 2015;64(3):381.

Article  PubMed  Google Scholar 

Ning ZH, Zhao W, Li XD, et al. The status of perineural invasion predicts the outcomes of postoperative radiotherapy in locally advanced esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2015;8(6):6881.

PubMed  PubMed Central  Google Scholar 

Huang Q, Luo K, Chen C, et al. Identification and Validation of Lymphovascular Invasion as a Prognostic and Staging Factor in Node-Negative Esophageal Squamous Cell Carcinoma. J Thorac Oncol. 2016;11(4):583-92.

Wang A, Tan Y, Wang S, Chen X. The prognostic value of separate lymphatic invasion and vascular invasion in oesophageal squamous cell carcinoma: a meta-analysis and systematic review. BMC Cancer. 2022;22(1):1329.

Article  PubMed  PubMed Central  Google Scholar 

Xu G, Feng F, Liu Z, et al. Prognosis and progression of ESCC patients with perineural invasion. Sci Rep. 2017;7:43828.

Article  PubMed  PubMed Central  Google Scholar 

Liu L, Lin H, Shen G, et al. Prognostic significance of lymphovascular invasion in patients with pT1b esophageal squamous cell carcinoma. BMC Cancer. 2023;23(1):370.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim HE, Park SY, Kim H, Kim DJ, Kim SI. Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma. Thoracic Cancer. 2021;12(10):1605–12.

Article  PubMed  PubMed Central  Google Scholar 

Chen SH, Zhang BY, Zhou B, et al. Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche. Am J Cancer Res. 2019;9(1):1.

PubMed  PubMed Central  Google Scholar 

Hsu H-Y, Chao Y-K, Hsieh C-H, et al. Postoperative adjuvant therapy improves survival in pathologic nonresponders after neoadjuvant chemoradiation for esophageal squamous cell carcinoma: a propensity-matched analysis. Ann Thorac Surg. 2016;102(5):1687–93.

Article  PubMed  Google Scholar 

Mori N, Mugikura S, Takasawa C, et al. Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer. Eur Radiol. 2016;26:31–339.

Kim H, Park MS, Choi JY, et al. Can microvessel invasion of hepatocellular carcinoma be predicted by pre-operative MRI? Eur Radiol. 2009;19(7):1744–51.

Article  PubMed  Google Scholar 

van Hagen P, Hulshof MC, Van Lanschot JJ, et al. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012;366(22):2074–84.

Ferlay J, Colombet M, Soerjomataram I, et al. Cancer statistics for the year 2020: an overview. Int J Cancer. 2021;15;149(4):778–89.

Nakajo M, Jinguji M, Nakabeppu Y, et al. Texture analysis of 18 F-FDG PET/CT to predict tumour response and prognosis of patients with esophageal cancer treated by chemoradiotherapy. Eur J Nucl Med Mol Imaging. 2017;44:206–14.

Article  CAS  PubMed  Google Scholar 

Paul D, Su R, Romain M, et al. Feature selection for outcome prediction in oesophageal cancer using genetic algorithm and random forest classifier. Comput Med Imaging Graph. 2017;60:42–9.

Article  PubMed  Google Scholar 

Ganeshan B, Skogen K, Pressney I, Coutroubis D, Miles K. Tumour heterogeneity in oesophageal cancer assessed by CT texture analysis: preliminary evidence of an association with tumour metabolism, stage, and survival. Clin Radiol. 2012;67(2):157–64.

Article  CAS  PubMed  Google Scholar 

Li Y, Yu M, Wang G, et al. Contrast-enhanced CT-based radiomics analysis in predicting lymphovascular invasion in esophageal squamous cell carcinoma. Front Oncol. 2021;11:644165.

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Bai G, Huang W, Zhang H, Chen W. A radiomics nomogram based on contrast-enhanced CT for preoperative prediction of Lymphovascular invasion in esophageal squamous cell carcinoma. Front Oncol. 2023;13:1208756.

Article  PubMed  PubMed Central  Google Scholar 

Zhou H, Zhou J, Qin C, et al. Preoperative prediction of perineural invasion in oesophageal squamous cell carcinoma based on ct radiomics nomogram: a multicenter study. Acad Radiol. 2024;31(4):1355–66.

Team, R.D.C. R: A language and environment for statistical computing. 2010.

Google Scholar 

Wang S, Chen X, Fan J, Lu L. Prognostic significance of lymphovascular invasion for thoracic esophageal squamous cell carcinoma. Ann Surg Oncol. 2016;23(12):4101–9.

Article  PubMed  Google Scholar 

Tachezy M, Tiebel AK, Gebauer F, et al. Prognostic impact of perineural, blood and lymph vessel invasion for esophageal cancer. Histol Histopathol. 2014;29(11):1467–75.

PubMed  Google Scholar 

Kim SI, Yoon JH, Lee SJ, et al. Prediction of lymphovascular space invasion in patients with endometrial cancer. Int J Med Sci. 2021;18(13):2828–34.

Article  PubMed  PubMed Central  Google Scholar 

Xu ML, Zeng SE, Li F, Cui XW, Liu GF. Preoperative prediction of lymphovascular invasion in patients with T1 breast invasive ductal carcinoma based on radiomics nomogram using grayscale ultrasound. Front Oncol. 2022;12:1071677.

Article  PubMed  PubMed Central  Google Scholar 

Chen X, Yang Z, Yang J, Liao Y, Chen X. Radiomics analysis of contrast-enhanced CT predicts lymphovascular invasion and disease outcome in gastric cancer: a preliminary study. Cancer Imaging. 2020;20(1):24.

Article  PubMed  PubMed Central  Google Scholar 

Zhang K, Ren Y, Xu S, et al. A clinical-radiomics model incorporating T2-weighted and diffusion-weighted magnetic resonance images predicts the existence of lymphovascular invasion / perineural invasion in patients with colorectal cancer. Med Phys. 2021;48(9):4872–82.

Article  PubMed  Google Scholar 

Kayadibi Y, Kocak B, Ucar N, et al. MRI radiomics of breast cancer: machine learning-based prediction of lymphovascular invasion status. Acad Radiol. 2022;29:S126–34.

Article  PubMed  Google Scholar 

Nijiati M, Aihaiti D, Huojia A, et al. MRI-based radiomics for preoperative prediction of lymphovascular invasion in patients with invasive breast cancer. Front Oncol. 2022;12:876624.

Article  PubMed  PubMed Central  Google Scholar 

Chen Q, Cui Y, Xue T, et al. Computed tomography-based radiomics nomogram for the preoperative prediction of perineural invasion in colorectal cancer: a multicentre