Detection of factor XIII inhibitors in 33 patients with autoimmune factor XIII deficiency in Japan

Lorand L. Factor XIII and the clotting of fibrinogen: from basic research to medicine. J Thromb Haemost. 2005;3:1337–48.

Article  CAS  PubMed  Google Scholar 

Muszbek L, Bereczky Z, Bagoly Z, Komáromi I, Katona É. Factor XIII: a coagulation factor with multiple plasmatic and cellular functions. Physiol Rev. 2011;91:931–72.

Article  CAS  PubMed  Google Scholar 

Ichinose A. Factor XIII is a key molecule at the intersection of coagulation and fibrinolysis as well as inflammation and infection control. Int J Hematol. 2012;95:362–70.

Article  CAS  PubMed  Google Scholar 

Schroeder V, Kohler HP. Factor XIII: structure and function. Semin Thromb Hemost. 2016;42:422–8.

Article  CAS  PubMed  Google Scholar 

Alshehri FSM, Whyte CS, Mutch NJ. Factor XIII-A: an indispensable “factor” in haemostasis and wound healing. Int J Mol Sci. 2021;22:3055.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ivaškevičius V, Biswas A, Garly ML, Oldenburg J. Comparison of F13A1 gene mutations in 73 patients treated with recombinant FXIII-A2. Haemophilia. 2017;23:e194–203.

Article  PubMed  Google Scholar 

Osaki T, Souri M, Ichinose A. Important roles of the human leukocyte antigen class I and II molecules and their associated genes in the autoimmune coagulation factor XIII deficiency via whole-exome sequencing analysis. PLoS ONE. 2021;16: e0257322.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Osaki T, Souri M, Ichinose A. Plasma proteomics associated with autoimmune coagulation factor deficiencies reveals the link between inflammation and autoantibody development. Int J Hematol. 2022;115:672–85.

Article  CAS  PubMed  Google Scholar 

Franchini M, Frattini F, Crestani S, Bonfanti C. Acquired FXIII inhibitors: a systematic review. J Thromb Thrombolysis. 2013;36:109–14.

Article  CAS  PubMed  Google Scholar 

Ichinose A, Japanese Collaborative Research Group on AH13. Autoimmune acquired factor XIII deficiency due to anti-factor XIII/13 antibodies: a summary of 93 patients. Blood Rev. 2017;31:37–45.

Article  CAS  PubMed  Google Scholar 

Tone KJ, James TE, Fergusson DA, et al. Acquired factor XIII inhibitor in hospitalized and perioperative patients: a systematic review of case reports and case series. Transfus Med Rev. 2016;30:123–31.

Article  PubMed  Google Scholar 

Muszbek L, Pénzes K, Katona É. Auto- and alloantibodies against factor XIII: laboratory diagnosis and clinical consequences. J Thromb Haemost. 2018;16:822–32.

Article  CAS  PubMed  Google Scholar 

Ichinose A, Osaki T, Souri M. Pathological coagulation parameters in as many as 54 patients with autoimmune acquired factor XIII deficiency due to anti-factor XIII autoantibodies. Haemophilia. 2021;27:454–62.

Article  CAS  PubMed  Google Scholar 

Ichinose A, Osaki T, Souri M. Autoimmune acquired factor XIII deficiency in Japan 2021 update: focused on annual incidence and clinical features. Haemophilia. 2022;28:e121–4.

Article  PubMed  Google Scholar 

Ajzner E, Schlammadinger A, Kerényi A, et al. Severe bleeding complications caused by an autoantibody against the B subunit of plasma factor XIII: a novel form of acquired factor XIII deficiency. Blood. 2009;113:723–5.

Article  CAS  PubMed  Google Scholar 

Souri M, Osaki T, Ichinose A. Anti-factor XIII A subunit (FXIII-A) autoantibodies block FXIII-A2B2 assembly and steal FXIII-A from native FXIII-A2B2. J Thromb Haemost. 2015;13:802–14.

Article  CAS  PubMed  Google Scholar 

Souri M, Ozawa T, Osaki T, Koyama T, Muraguchi A, Ichinose A. Cloning of human anti-factor XIII monoclonal antibody dissects mechanisms of polyclonal antibodies in a single patient. J Thromb Haemost. 2023;21:255–68.

Article  PubMed  Google Scholar 

Ichinose A. Diagnosis and treatment of acquired factor XIII/13 deficiencies: for all doctors treating the MHLW’s designated intractable diseases. Rinsho Ketsueki. 2015;56:2110–22.

PubMed  Google Scholar 

Ichinose A, Osaki T, Souri M, Japanese Collaborative Research Group (JCRG) on AH13 (supported by the Japanese Ministry of Health, Labor, and Welfare). Clinical features of 32 new Japanese cases with autoimmune hemorrhaphilia due to anti-factor XIII antibodies. Haemophilia. 2015;21:653–8.

Article  CAS  PubMed  Google Scholar 

Ichinose A, Kohler HP, Philippou H, Factor XIII and Fibrinogen SSC Subcommittee of the ISTH. Recommendation for ISTH/SSC Criterion 2015 for autoimmune acquired factor XIII/13 deficiency. Thromb Haemost. 2016;116:772–4.

Article  PubMed  Google Scholar 

Ichinose A, Wada H, Souri M, et al. Guidance on diagnostic criteria for autoimmune hemorrhaphilia FXIII/13 (AHFXIII/13). Jap J Thromb Hemost. 2015;26:658–68.

Article  Google Scholar 

Ichinose A, Wada H, Souri M, et al. Guidance on diagnosis and management of autoimmune hemorrhaphilia FXIII/13 (AHFXIII/13). Jap J Thromb Hemost. 2017;28:393–420.

Article  Google Scholar 

Sakata Y, Aoki N. Cross-linking of alpha 2-plasmin inhibitor to fibrin by fibrin-stabilizing factor. J Clin Invest. 1980;65:290–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tamaki T, Aoki N. Cross-linking of alpha 2-plasmin inhibitor and fibronectin to fibrin by fibrin-stabilizing factor. Biochim Biophys Acta. 1981;661:280–6.

Article  CAS  PubMed  Google Scholar 

Lee KN, Lee CS, Tae WC, Jackson KW, Christiansen VJ, McKee PA. Crosslinking of alpha 2-antiplasmin to fibrin. Ann N Y Acad Sci. 2001;936:335–9.

Article  CAS  PubMed  Google Scholar 

Ichinose A, Souri M. Reduced difference of α2-plasmin inhibitor levels between plasma and serum in patients with severe factor XIII deficiency, including autoimmune hemorrhaphilia due to anti-factor XIII antibodies. Int J Hematol. 2012;95:47–50.

Article  CAS  PubMed  Google Scholar 

Tamaki T, Aoki N. Cross-linking of alpha 2-plasmin inhibitor to fibrin catalyzed by activated fibrin-stabilizing factor. J Biol Chem. 1982;257:14767.

Article  CAS  PubMed  Google Scholar 

Ichinose A, Tamaki T, Aoki N. Factor XIII-mediated cross-linking of NH2-terminal peptide of alpha 2-plasmin inhibitor to fibrin. FEBS Lett. 1983;153:369–71.

Article  CAS  PubMed  Google Scholar 

Lee KN, Lee CS, Tae WC, Jackson KW, Christiansen VJ, McKee PA. Cross-linking of wild-type and mutant alpha 2-antiplasmins to fibrin by activated factor XIII and by a tissue transglutaminase. J Biol Chem. 2000;275:37382–9.

Article  CAS  PubMed  Google Scholar 

Cleary DB, Maurer MC. Characterizing the specificity of activated Factor XIII for glutamine-containing substrate peptides. Biochim Biophys Acta. 2006;1764:1207–17.

Article  CAS  PubMed  Google Scholar 

Lee KN, Birckbichler PJ, Patterson MK Jr. Colorimetric assay of blood coagulation factor XIII in plasma. Clin Chem. 1988;34:906–10.

Article  CAS  PubMed  Google Scholar 

Slaughter TF, Achyuthan KE, Lai TS, Greenberg CS. A microtiter plate transglutaminase assay utilizing 5-(biotinamido)pentylamine as substrate. Anal Biochem. 1992;205:166–71.

Article  CAS  PubMed 

Comments (0)

No login
gif