Katsurada K, Shinohara K, Aoki J, Nanto S, Kario K. Renal denervation: basic and clinical evidence. Hypertens Res. 2022;45:198–209.

Article  PubMed  Google Scholar 

Osborn JW, Foss JD. Renal nerves and long-term control of arterial pressure. Compr Physiol. 2017;7:263–320.

Article  PubMed  Google Scholar 

Katsurada K, Patel KP. The role of afferent renal nerves in regulating sympathetic outflow via central nervous system mechanisms. Hypertens Res. 2024;47:1978–80.

Article  PubMed  Google Scholar 

Patel KP, Katsurada K, Zheng H. Cardiorenal syndrome: the role of neural connections between the heart and the kidneys. Circ Res. 2022;130:1601–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bohm M, Kario K, Kandzari DE, Mahfoud F, Weber MA, Schmieder RE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet. 2020;395:1444–51.

Article  PubMed  Google Scholar 

Kandzari DE, Bohm M, Mahfoud F, Townsend RR, Weber MA, Pocock S, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial. Lancet. 2018;391:2346–55.

Article  PubMed  Google Scholar 

Azizi M, Schmieder RE, Mahfoud F, Weber MA, Daemen J, Davies J, et al. Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial. Lancet. 2018;391:2335–45.

Article  PubMed  Google Scholar 

Azizi M, Sanghvi K, Saxena M, Gosse P, Reilly JP, Levy T, et al. Ultrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial. Lancet. 2021;397:2476–86.

Article  CAS  PubMed  Google Scholar 

Ogoyama Y, Abe M, Okamura K, Tada K, Katsurada K, Shibata S, et al. Effects of renal denervation on blood pressure in patients with hypertension: a latest systematic review and meta-analysis of randomized sham-controlled trials. Hypertens Res. 2024. https://doi.org/10.1038/s41440-024-01739-y. Online ahead of print.

Mahfoud F, Kandzari DE, Kario K, Townsend RR, Weber MA, Schmieder RE, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. Lancet. 2022;399:1401–10.

Article  CAS  PubMed  Google Scholar 

Bhatt DL, Vaduganathan M, Kandzari DE, Leon MB, Rocha-Singh K, Townsend RR, et al. Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial. Lancet. 2022;400:1405–16.

Article  PubMed  Google Scholar 

Vogt A, Dutzmann J, Nussbaum M, Hoyer D, Tongers J, Schlitt A, et al. Safety and efficacy of renal sympathetic denervation: a 9-year long-term follow-up of 24-hour ambulatory blood pressure measurements. Front Cardiovasc Med. 2023;10:1210801.

Article  PubMed  PubMed Central  Google Scholar 

Al Ghorani H, Kulenthiran S, Recktenwald MJM, Lauder L, Kunz M, Gotzinger F, et al. 10-year outcomes of catheter-based renal denervation in patients with resistant hypertension. J Am Coll Cardiol. 2023;81:517–9.

Article  PubMed  Google Scholar 

Al Ghorani H, Kulenthiran S, Lauder L, Recktenwald MJM, Dederer J, Kunz M, et al. Ultra-long-term efficacy and safety of catheter-based renal denervation in resistant hypertension: 10-year follow-up outcomes. Clin Res Cardiol. 2024. https://doi.org/10.1007/s00392-024-02417-2. Online ahead of print.

Wang L, Li C, Li Z, Li Q, Liu C, Sun X, et al. Ten-year follow-up of very-high risk hypertensive patients undergoing renal sympathetic denervation. J Hypertens. 2024;42:801–8.

Article  CAS  PubMed  Google Scholar 

Mancia G, Kreutz R, Brunstrom M, Burnier M, Grassi G, Januszewicz A, et al. 2023 ESH Guidelines for the management of arterial hypertension the Task Force for the management of arterial hypertension of the European Society of Hypertension: endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens. 2023;41:1874–2071.

Article  CAS  PubMed  Google Scholar 

Wang K, Qi Y, Gu R, Dai Q, Shan A, Li Z, et al. Renal denervation attenuates adverse remodeling and intramyocardial inflammation in acute myocardial infarction with ischemia-reperfusion injury. Front Cardiovasc Med. 2022;9:832014.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen H, Wang R, Li Q, Yin J, Ge Z, Xu F, et al. Immediate renal denervation after acute myocardial infarction mitigates the progression of heart failure via the modulation of IL-33/ST2 signaling. Front Cardiovasc Med. 2021;8:746934.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun X, Wei Z, Li Y, Wang J, Hu J, Yin Y, et al. Renal denervation restrains the inflammatory response in myocardial ischemia-reperfusion injury. Basic Res Cardiol. 2020;115:15.

Article  CAS  PubMed  Google Scholar 

Polhemus DJ, Gao J, Scarborough AL, Trivedi R, McDonough KH, Goodchild TT, et al. Radiofrequency renal denervation protects the ischemic heart via inhibition of GRK2 and increased nitric oxide signaling. Circ Res. 2016;119:470–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang W, Chen C, Huo J, Lu D, Jiang Z, Geng J, et al. Comparison between renal denervation and metoprolol on the susceptibility of ventricular arrhythmias in rats with myocardial infarction. Sci Rep. 2018;8:10206.

Article  PubMed  PubMed Central  Google Scholar 

Ye J, Xiao R, Wang X, He R, Liu Z, Gao J. Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats. BMC Cardiovasc Disord. 2022;22:544.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang SN, Chang SH, Yu CC, Wu CK, Lai LP, Chiang FT, et al. Renal denervation decreases susceptibility to arrhythmogenic cardiac alternans and ventricular arrhythmia in a rat model of post-myocardial infarction heart failure. JACC Basic Transl Sci. 2017;2:184–93.

Article  PubMed  PubMed Central  Google Scholar 

Zhang B, Li X, Chen C, Jiang W, Lu D, Liu Q, et al. Renal denervation effects on myocardial fibrosis and ventricular arrhythmias in rats with ischemic cardiomyopathy. Cell Physiol Biochem. 2018;46:2471–9.

Article  CAS  PubMed  Google Scholar 

Jackson N, Gizurarson S, Azam MA, King B, Ramadeen A, Zamiri N, et al. Effects of renal artery denervation on ventricular arrhythmias in a postinfarct model. Circ Cardiovasc Inter. 2017;10:e004172.

CAS  Google Scholar 

Linz D, Wirth K, Ukena C, Mahfoud F, Poss J, Linz B, et al. Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs. Heart Rhythm. 2013;10:1525–30.

Article  PubMed  Google Scholar 

Kim SS, Kim HK, Park HW, Jeong MH, Lim KS, Kee HJ, et al. Effect of renal denervation on suppression of PVC and QT prolongation in a porcine model of acute myocardial infarction. Korean Circ J. 2020;50:38–49.

Article  CAS  PubMed  Google Scholar 

Gao JQ, Xu YL, Ye J, Hou SX, Yang W, Li M, et al. Effects of renal denervation on cardiac function after percutaneous coronary intervention in patients with acute myocardial infarction. Heliyon. 2023;9:e17591.

Article  PubMed  PubMed Central  Google Scholar 

Hoffmann BA, Steven D, Willems S, Sydow K. Renal sympathetic denervation as an adjunct to catheter ablation for the treatment of ventricular electrical storm in the setting of acute myocardial infarction. J Cardiovasc Electrophysiol. 2013;24:1175–8.

Article  PubMed  Google Scholar 

Patel KP, Xu B, Liu X, Sharma NM, Zheng H. Renal denervation improves exaggerated sympathoexcitation in rats with heart failure: a role for neuronal nitric oxide synthase in the paraventricular nucleus. Hypertension. 2016;68:175–84.

Article  CAS  PubMed  Google Scholar 

Zheng H, Katsurada K, Liu X, Knuepfer MM, Patel KP. Specific afferent renal denervation prevents reduction in neuronal nitric oxide synthase within the paraventricular nucleus in rats with chronic heart failure. Hypertension. 2018;72:667–75.

Article  CAS  PubMed  Google Scholar 

Katsurada K, Ogoyama Y, Imai Y, Patel KP, Kario K. Renal denervation based on experimental rationale. Hypertens Res. 2021;44:1385–94.