Organization of the Reserve Pool of Synaptic Vesicles in Nerve Terminals Lacking Protein Liquid Phase Components

Pieribone V.A., Shupliakov O., Brodin, L., Hilfiker-Rothenfluh S., Czernik A.J., Greengard P. 1995. Distinct pools of synaptic vesicles in neurotransmitter release. Nature. 375, 493–497.

Article  CAS  PubMed  Google Scholar 

Rizzoli S.O., Betz W.J. 2004. The structural organization of the readily releasable pool of synaptic vesicles. Science. 303, 2037–2039.

Article  CAS  PubMed  Google Scholar 

Brodin L., Milovanovic D., Rizzoli S.O., Shupliakov O. 2022. alpha-Synuclein in the synaptic vesicle liquid phase: Active player or passive bystander? Front. Mol. Biosci. 9, 891508.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Milovanovic D., Wu Y., Bian X., De Camilli P. 2018. A liquid phase of synapsin and lipid vesicles. Science. 361, 604–607.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pechstein A., Tomilin N., Fredrich K., Vorontsova O., Sopova E., Evergren E., Haucke V., Brodin L., Shupliakov O. 2020. Vesicle clustering in a living synapse depends on a synapsin region that mediates phase separation. Cell Rep. 30, 2594–2602. e3.

Shupliakov O. 2009. The synaptic vesicle cluster: A source of endocytic proteins during neurotransmitter release. Neuroscience. 158, 204–210.

Article  CAS  PubMed  Google Scholar 

Denker A., Kröhnert K., Bückers J., Neher E., Rizzoli S.O. 2011. The reserve pool of synaptic vesicles acts as a buffer for proteins involved in synaptic vesicle recycling. Proc. Natl. Acad. Sci. USA. 108, 17 183–17 188.

Article  Google Scholar 

Sundborger A., Soderblom C., Vorontsova O., Evergren E., Hinshaw J. E., Shupliakov O. 2011. An endophilin-dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling. J. Cell. Sci. 124, 133–143.

Article  CAS  PubMed  Google Scholar 

Yoshida T., Takenaka K.I., Sakamoto H., Kojima Y., Sakano T., Shibayama K., Nakamura K., Hanawa-Suetsugu K., Mori Y., Hirabayashi Y., Hirose K., Takamori S. 2023. Compartmentalization of soluble endocytic proteins in synaptic vesicle clusters by phase separation. iScience. 26, 106826.

Milosevic I., Giovedi S., Lou X., Raimondi A., Collesi C., Shen H., Paradise S., O’Toole E., Ferguson S., Cremona O., De Camilli P. 2011. Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Neuron. 72, 587–601.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raimondi A., Ferguson S.M., Lou X., Armbruster M., Paradise S., Giovedi S., Messa M., Kono N., Takasaki J., Cappello V., O’Toole E., Ryan T.A., De Camilli P. 2011. Overlapping role of dynamin isoforms in synaptic vesicle endocytosis. Neuron. 70, 1100–1114.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gad H., Ringstad N., Low P., Kjaerulff O., Gustafsson J., Wenk M., Di Paolo G., Nemoto Y., Crun J., Ellisman M.H., De Camilli P., Shupliakov O., Brodin L. 2000. Fission and uncoating of synaptic clathrin-coated vesicles are perturbed by disruption of interactions with the SH3 domain of endophilin. Neuron. 27, 301–312.

Article  CAS  PubMed  Google Scholar 

Shishkov A.G., Nifantova N.V., Korenkova O.M., Sopova E.S., Brodin L., Shupliakov O. 2023. BAR domain proteins as putative regulators of the protein liquid phase in nerve terminals in the central nervous system. Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 17, 69–82.

CAS  Google Scholar 

Ferguson S.M., Brasnjo G., Hayashi M., Wolfel M., Collesi C., Giovedi S., Raimondi A., Gong L.W., Ariel P., Paradise S., O’Toole E., Flavell R., Cremona O., Miesenbock G., Ryan T.A., De Camilli P. 2007. A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. Science. 316, 570–574.

Article  CAS  PubMed  Google Scholar 

Hoffmann C., Sansevrino R., Morabito G., Logan C., Vabulas R.M., Ulusoy A., Ganzella M., Milovanovic D. 2021. Synapsin condensates recruit alpha-synuclein. J. Mol. Biol. 433, 166961.

Article  CAS  PubMed  Google Scholar 

Vargas K.J., Schrod N., Davis T., Fernandez-Busnadiego R., Taguchi Y.V., Laugks U., Lucic V., Chandra S.S. 2017. synucleins have multiple effects on presynaptic architecture. Cell Rep. 18, 161–173.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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