Clinical Obstetrics and Gynecology

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Erratum

Clinical Obstetrics and Gynecology | DOI: 10.1097/GRF.0000000000000429 Metrics

In the March 2019 issue of Clinical Obstetrics and Gynecology, an error appeared in Table 2 of this article by Shyken et al.1 This version of the table was not final, and so was missing some references as well as the final wording about some of the pregnancy risks. The correct table and list of references cited appears below.

TABLE 2 - Common Preventative Anxiety Medications13,48–51 Anxiety Indications Generic Name (Brand Name) GAD OCD Panic PTSD Social Depression Indication Total Daily Dosing (mg) Pregnancy Concerns Selective serotonin reuptake inhibitor (SSRI) Citalopram (Celexa) X* X* X* X 10-40 First trimester: mixed data for risk of cardiovascular malformations
Paroxetine: associated with cardiovascular malformations in doses >25 mg/d
Second/third trimesters: mixed data for the risk of neonatal behavior, neonatal withdrawal possible  Escitalopram (Lexapro) X X* X* X* X 5-20  Fluoxetine (Prozac) X X X* X* X 10-80  Fluvoxamine (Luvox) X X* X* X* X* 50-300  Paroxetine (Paxil) X X X X X X 10-50 (12.5-62.5 CR)  Sertraline (Zoloft) X* X X X X X 25-200  Vortioxetine (Trintellix) X 5-20 Serotonin norepinephrine reuptake inhibitor (SNRI) Desvenlafaxine (Pristique) X 50-400 No human data desvenlafaxine or levomilnacipran
Second/third trimesters: neonatal withdrawal possible  Duloxetine (Cymbalta) X X 30-120 Levomilnacipran (Fetzima) X 20-120  Venlafaxine (Effexor) X X* X X* X X 37.5-225 Miscellaneous  Buspirone (Buspar) X X* 10-60 Divided into 2-3 doses per day SSRI/5-HT1A receptor partial agonist  Vilazodone (Viibryd) X 10-40 No human data

GAD indicates general anxiety disorder; OCD, obsessive compulsive disorder; Panic, panic disorder; PTSD, posttraumatic stress disorder; Social, social anxiety disorder; X, FDA indication; X*, off-label use.

References cited in Table 2:

13. Lexi-Comp Inc. (Lexi-Drugs). Lexi-Comp, Inc.; August 31, 2018. 48. Briggs GG, Freeman R, Tower CV, et al. Drug use in pregnancy and lactation, 11th ed. Philadelphia: Wolters Kluwer; 2017. 49. Ornoy A. Neurobehavioral risks of SSRI’s in pregnancy: comparing human and animal data. Reprod Toxicol 2017;109:898–908. 50. Ornoy A, Koren G. Selective serotonin reuptake inhibitors during pregnancy: do we have now more definite answers related to prenatal exposures? Birth Defects Res 2017;109:898–908. 51. Liu X, Agerbo E, Ingstrup KG, et al. Antidepressant use during pregnancy and psychiatric disorders in offspring: Danish Nationwide Register Based Cohort Study. BMJ 2017;358:j3668. http://dx.doi.org/10.1136/bmj.j3668. 1. Shyken J, Babbar S, Babbar S, et al. Benzodiazepines in pregnancy. Clin Ob Gyn. 2019;62:156–167. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.