Dragon’s blood attenuates LPS-induced intestinal epithelial barrier dysfunction via upregulation of FAK-DOCK180-Rac1-WAVE2-Arp3 and downregulation of TLR4/NF-κB signaling pathways

Lee SI, Kang KS (2019) N-acetylcysteine modulates lipopolysaccharide-induced intestinal dysfunction. Sci Rep 9:1004

Article  PubMed  PubMed Central  Google Scholar 

Wu JT, He CM, Bu J, Luo Y, Yang SY, Ye CY, Yu SL, He BS, Yin YL, Yang XP (2020) Betaine attenuates LPS-induced downregulation of Occludin and Claudin-1 and restores intestinal barrier function. BMC Vet Res 16:75

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garcia-Hernandez V, Quiros M, Nusrat A (2017) Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation. Ann N Y Acad Sci 1397:66–79

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu XX, Huang XL, Chen RR, Li T, Ye HJ, Xie W, Huang ZM, Cao GZ (2019) Paeoniflorin prevents intestinal barrier disruption and inhibits lipopolysaccharide (LPS)-induced inflammation in Caco-2 cell monolayers. Inflammation 42:2215–2225

Article  CAS  PubMed  Google Scholar 

Zhou ZB, Yang B, Li X, Liu H, Lei G (2018) Lysophosphatidic acid promotes expression and activation of matrix metalloproteinase 9 (MMP9) in THP-1 cells via toll-like receptor 4/nuclear factor-κB (TLR4/NF-κB) signaling pathway. Med Sci Monit 24:4861–4868

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rowart P, Wu J, Caplan MJ, Jouret F (2018) Implications of AMPK in the formation of epithelial tight junctions. Int J Mol Sci 19:2040

Article  PubMed  PubMed Central  Google Scholar 

Wang SB, Zhang YS, Guo JJ, Kang LT, Deng YL, Li YJ (2020) Investigation on rat intestinal homeostasis alterations induced by 7-day simulated microgravity effect based on a proteomic approach. Acta Astronaut 166:560–566

Article  CAS  Google Scholar 

Ivanov AI, Hunt D, Utech M, Nusrat A, Parkos CA (2005) Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex. Mol Biol Cell 16:2636–2650

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ivanov AI (2008) Actin motors that drive formation and disassembly of epithelial apical junctions. Front Biosci 13:6662–6681

Article  CAS  PubMed  Google Scholar 

Lechuga S, Ivanov AI (2017) Disruption of the epithelial barrier during intestinal inflammation: quest for new molecules and mechanisms. Biochim Biophys Acta Mol Cell Res 1864:1183–1194

Article  CAS  PubMed  Google Scholar 

Omonijo FA, Liu S, Hui Q, Zhang H, Lahaye L, Bodin JC, Gong J, Nyachoti M, Yang C (2019) Thymol improves barrier function and attenuates inflammatory responses in porcine intestinal epithelial cells during lipopolysaccharide (LPS)-induced inflammation. J Agric Food Chem 67:615–624

Article  CAS  PubMed  Google Scholar 

Kawasaki T, Kawai T (2014) Toll-like receptor signaling pathways. Front Immunol 5:461

Article  PubMed  PubMed Central  Google Scholar 

Nighot M, Al-Sadi R, Guo S, Rawat M, Nighot P, Watterson MD, Ma TY (2017) Lipopolysaccharide-induced increase in intestinal epithelial tight permeability is mediated by toll-like receptor 4/myeloid differentiation primary response 88 (MyD88) activation of myosin light chain kinase expression. Am J Pathol 187:2698–2710

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kong L, Sun L, Zhang HX, Liu Q, Liu Y, Qin LH, Shi GJ, Hu JH, Xu AJ, Sun YP, Li DS, Shi YF, Zang JW, Zhu J, Chen Z, Wang ZG, Ge BX (2009) An essential role for RIG-I in toll-like receptor-stimulated phagocytosis. Cell Host Microbe 6:150–161

Article  CAS  PubMed  Google Scholar 

Gil-Cardoso K, Comitato R, Ginés I, Ardévol A, Pinent M, Virgili F, Terra X, Blay M (2019) Protective effect of proanthocyanidins in a rat model of mild intestinal inflammation and impaired intestinal permeability induced by LPS. Mol Nutr Food Res 63:e1800720

Article  PubMed  Google Scholar 

Lan H, Zhang LY, He W, Li WY, Zeng Z, Qian B, Wang C, Song JL (2021) Sinapic acid alleviated inflammation-induced intestinal epithelial barrier dysfunction in lipopolysaccharide- (LPS-) treated Caco-2 cells. Mediators Inflamm 2021:5514075

Article  PubMed  PubMed Central  Google Scholar 

Lin YL, Xiong WN, Xiao SM, Li F, Lu Z, Yan JY, Fang XW, Cui XJ, Wen YL, Liang JQ, Yu K (2020) Pharmacoproteomics reveals the mechanism of Chinese dragon’s blood in regulating the RSK/TSC2/mTOR/ribosome pathway in alleviation of DSS-induced acute ulcerative colitis. J Ethnopharmacol 263:113221

Article  CAS  PubMed  Google Scholar 

Li M, Liu X (2021) Clinical study on treating ulcerative colitis treated with licorice heart-draining decoction vombined with longxuejie capsule. Henan Tradit Chin Med 41:840–843

Google Scholar 

Ye K, Li JX, Mei F (2017) Evaluation of the therapeutic effect of Longxuejie powder enema combined with oral mesalazine in the treatment of ulcerative colitis. Guizhou Med J 41:709–711

CAS  Google Scholar 

Liu WY, Tian JH (2017) Clinical study on the therapy of promoting blood circulation and removing slough as well as promoting growth of tissue regeneration in the treatment of chronic gastritis with intestinal metaplasia. Chi Med Mod Dist Edu CN 15:85–86

Google Scholar 

Zhao BJ, Wang ZZ, Luo HP, Guo JK, Ji HW, Wang J, Yang LY, Xiao W (2017) A multi-center, double-blind, placebo-controlled, randomized trial for effect of longxue tongluo capsule in treatment of patients of atherosclerotic thrombotic cerebral infarction with blood-stasis syndrome in convalescence. J Trad Chi Med 41:3473–3477

Google Scholar 

Li YS, Wang JX, Jia MM, Liu M, Li XJ, Tang HB (2012) Dragon’s blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance P in rats. J Pharmacol Sci 18:43–54

Article  Google Scholar 

Namjoyan F, Kiashi F, Moosavi ZB, Saffari F, Makhmalzadeh BS (2015) Efficacy of Dragon’s blood cream on wound healing: a randomized, double-blind, placebo-controlled clinical trial. J Tradit Complement Med 6:37–40

Article  PubMed  PubMed Central  Google Scholar 

Wang H, Luo Y, Dai HF, Mei WL (2013) Antibacterial activity against Ralstonia solanacearum of phenolic constituents isolated from dragon’s blood. Nat Prod Commun 8:337–338

CAS  PubMed  Google Scholar 

Cui XJ, Feng JF, Chen Y, Yan JY, Xiong WN, Li F, Liang JQ (2019) Mechanisms of Chinese Dragon’s blood on alleviating colonic mucosal damage in mice with ulceratice colitis based on network pharmacology. Chin Tradit Herbal Drugs 50:3872–3879

Google Scholar 

Cai BL, Wen YL (2022) The mechanism of Dragon’s blood in treating ulcerative colitis based on network pharmacology. J Mod Med Health 38(721–724):728

Google Scholar 

Srinivasan B, Kolli AR, Esch MB, Abaci HE, Shuler ML, Hickman JJ (2015) TEER measurement techniques for in vitro barrier model systems. J Lab Autom 20:107–126

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu XY, Yu Q, Hou KY, Ding XM, Chen Y, Xie JH, Nie SP, Xie MY (2020) Regulatory effects of Ganoderma atrum polysaccharides on LPS-induced inflammatory macrophages model and intestinal-like Caco-2/macrophages co-culture inflammation model. Food Chem Toxicol 140:111321

Article  CAS  PubMed  Google Scholar 

Saijo H, Tatsumi N, Arihiro S, Kato T, Okabe M, Tajiri H, Hashimoto H (2015) Microangiopathy triggers, and inducible nitric oxide synthase exacerbates dextran sulfate sodium-induced colitis. Lab Invest 95:728–748

Article  CAS  PubMed  Google Scholar 

Bian YF, Dong YY, Sun JJ, Sun M, Hou QH, Lai YJ, Zhang BK (2020) Protective effect of kaempferol on LPS-induced inflammation and barrier dysfunction in a coculture model of intestinal epithelial cells and intestinal microvascular endothelial cells. J Agric Food Chem 68:160–167

Article  CAS  PubMed  Google Scholar 

Kasper JY, Hermanns MI, Cavelius C, Kraegeloh A, Jung T, Danzebrink R, Unger RE, Kirkpatrick CJ (2016) The role of the intestinal microvasculature in inflammatory bowel disease: studies with a modified Caco-2 model including endothelial cells resembling the intestinal barrier in vitro. Int J Nanomedicine 11:6353–6364

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferrari D, Cimino F, Fratantonio D, Molonia MS, Bashllari R, Busà R, Saija A, Speciale A (2017) Cyanidin-3-O-Glucoside modulates the in vitro inflammatory crosstalk between intestinal epithelial and endothelial cells. Mediators Inflamm 2017:3454023

Comments (0)

No login
gif