Haemostatic gene variations in cervical cancer-associated venous thrombosis: considerations for clinical strategies

Mensah GA, Roth GA, Fuster V (2019) The global burden of cardiovascular diseases and risk factors: 2020 and beyond. American College of Cardiology Foundation Washington, DC, pp 2529–2532

Tavares V, Pinto R, Assis J, Coelho S, Brandao M, Alves S, Pereira D, Medeiros R (2021) Implications of venous thromboembolism GWAS reported genetic makeup in the clinical outcome of ovarian cancer patients. Pharmacogenomics J 21(2):222–232

CAS  PubMed  Google Scholar 

DeVita VT, Lawrence TS, Rosenberg SA (2008) DeVita, Hellman, and Rosenberg’s cancer: principles & practice of oncology. Lippincott Williams & Wilkins

de Araujo Trugilho I, Renni MJP, Medeiros GC, Thuler LCS, Bergmann A (2020) Incidence and factors associated with venous thromboembolism in women with gynecologic cancer. Thromb Res 185:49–54

Google Scholar 

Heit JA, Spencer FA, White RH (2016) The epidemiology of venous thromboembolism. J Thromb Thrombolysis 41(1):3–14

CAS  PubMed  PubMed Central  Google Scholar 

Lim W, Le Gal G, Bates SM, Righini M, Haramati LB, Lang E, Kline JA, Chasteen S, Snyder M, Patel P (2018) American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism. Blood Adv 2(22):3226–3256

PubMed  PubMed Central  Google Scholar 

Liz-Pimenta J, Tavares V, Neto BV, Santos JM, Guedes CB, Araújo A, Khorana AA, Medeiros R (2023) Thrombosis and cachexia in cancer: two partners in crime? Crit Rev Oncol/Hematol 103989

Cushman M (2005) Inherited risk factors for venous thrombosis. ASH Educ Program Book 2005(1):452–457

Google Scholar 

Navarrete S, Solar C, Tapia R, Pereira J, Fuentes E, Palomo I (2023) Pathophysiology of deep vein thrombosis. Clin Experimental Med 23(3):645–654

CAS  Google Scholar 

Kaur S, Ali A, Ahmad U, Siahbalaei Y, Pandey A, Singh B (2019) Role of single nucleotide polymorphisms (SNPs) in common migraine. Egypt J Neurol Psychiatry Neurosurg 55(1):1–7

Google Scholar 

Tavares V, Pinto R, Assis J, Pereira D, Medeiros R (2020) Venous thromboembolism GWAS reported genetic makeup and the hallmarks of cancer: linkage to ovarian tumour behaviour. Biochim et Biophys Acta (BBA)-Reviews Cancer 1873(1):188331

CAS  Google Scholar 

Fernandes CJ, Morinaga LTK, Alves JLJ, Castro MA, Calderaro D, Jardim CVP, Souza R (2019) Cancer-associated thrombosis: the when, how and why. Eur Respir Rev 28(151)

Lutsey PL, Zakai NA (2023) Epidemiology and prevention of venous thromboembolism. Nat Reviews Cardiol 20(4):248–262

Google Scholar 

Satoh T, Matsumoto K, Tanaka YO, Akiyama A, Nakao S, Sakurai M, Ochi H, Onuki M, Minaguchi T, Sakurai H (2013) Incidence of venous thromboembolism before treatment in cervical cancer and the impact of management on venous thromboembolism after commencement of treatment. Thromb Res 131(4):e127–e132

CAS  PubMed  Google Scholar 

Tavares V, Neto BV, Vilas-Boas MI, Pereira D, Medeiros R (2022) Impact of hereditary thrombophilia on cancer-associated thrombosis, tumour susceptibility and progression: a review of existing evidence, Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 188778

Tavares V, Neto BV, Marques IS, Assis J, Pereira D, Medeiros R (2023) Cancer-associated thrombosis: what about microRNAs targeting the tissue factor coagulation pathway? Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 189053

Khorana AA, Mackman N, Falanga A, Pabinger I, Noble S, Ageno W, Moik F, Lee AY (2022) Cancer-associated venous thromboembolism. Nat Reviews Disease Primers 8(1):1–18

Google Scholar 

Neto BV, Tavares V, da Silva JB, Liz-Pimenta J, Marques IS, Carvalho L, Salgado L, Pereira D, Medeiros R (2023) Thrombogenesis-associated genetic determinants as predictors of thromboembolism and prognosis in cervical cancer. Sci Rep 13(1):9519

CAS  PubMed  PubMed Central  Google Scholar 

Prat J, Oncology FCoG (2015) FIGO’s staging classification for cancer of the ovary, fallopian tube, and peritoneum: abridged republication. J Gynecol Oncol 26(2):87–89

CAS  PubMed  PubMed Central  Google Scholar 

Quinn BA, Deng X, Colton A, Bandyopadhyay D, Carter JS, Fields EC (2019) Increasing age predicts poor cervical cancer prognosis with subsequent effect on treatment and overall survival. Brachytherapy 18(1):29–37

PubMed  Google Scholar 

Wright JD, Matsuo K, Huang Y, Tergas AI, Hou JY, Khoury-Collado F, Clair CMS, Ananth CV, Neugut AI, Hershman DL (2019) Prognostic performance of the 2018 International Federation of Gynecology and Obstetrics cervical cancer staging guidelines. Obstet Gynecol 134(1):49

PubMed  PubMed Central  Google Scholar 

Khorana AA, Mackman N, Falanga A, Pabinger I, Noble S, Ageno W, Moik F, Lee AY (2022) Cancer-associated venous thromboembolism. Nat Reviews Disease Primers 8(1):11

PubMed  Google Scholar 

Falanga A, Marchetti M (2023) Cancer-associated thrombosis: enhanced awareness and pathophysiologic complexity. J Thromb Haemost

Sang Y, Roest M, de Laat B, de Groot PG, Huskens D (2021) Interplay between platelets and coagulation. Blood Rev 46:100733

CAS  PubMed  Google Scholar 

Barbera L, Thomas G (2008) Venous thromboembolism in cervical cancer. Lancet Oncol 9(1):54–60

PubMed  Google Scholar 

Jacobson G, Lammli J, Zamba G, Hua L, Goodheart MJ (2009) Thromboembolic events in patients with cervical carcinoma: incidence and effect on survival. Gynecol Oncol 113(2):240–244

PubMed  Google Scholar 

Matsuo K, Moeini A, Machida H, Fullerton ME, Shabalova A, Brunette LL, Roman LD (2016) Significance of venous thromboembolism in women with cervical cancer. Gynecol Oncol 142(3):405–412

PubMed  PubMed Central  Google Scholar 

Wun T, Law L, Harvey D, Sieracki B, Scudder SA, Ryu JK (2003) Increased incidence of symptomatic venous thrombosis in patients with cervical carcinoma treated with concurrent chemotherapy, radiation, and erythropoietin. CA Cancer J Clin 98(7):1514–1520

CAS  Google Scholar 

Temkin S, Hellmann M, Serur E, Lee Y-C, Abulafia O (2006) Erythropoietin administration during primary treatment for locally advanced cervical carcinoma is associated with poor response to radiation. Int J Gynecol Cancer 16(5)

Pötter R, Dimopoulos J, Bachtiary B, Sissolak G, Klos B, Rheinthaller A, Kirisits C (2006) Knocke-Abulesz, 3D conformal HDR-brachy-and external beam therapy plus simultaneous cisplatin for high-risk cervical cancer: clinical experience with 3 year follow-up. Radiother Oncol 79(1):80–86

PubMed  Google Scholar 

Thomas G, Ali S, Hoebers FJ, Darcy KM, Rodgers WH, Patel M, Abulafia O, Lucci JA III, Begg AC (2008) Phase III trial to evaluate the efficacy of maintaining hemoglobin levels above 12.0 g/dL with erythropoietin vs above 10.0 g/dL without erythropoietin in anemic patients receiving concurrent radiation and cisplatin for cervical cancer. Gynecol Oncol 108(2):317–325

CAS  PubMed  Google Scholar 

Jacobson GM, Kamath RS, Smith BJ, Goodheart MJ (2005) Thromboembolic events in patients treated with definitive chemotherapy and radiation therapy for invasive cervical cancer. Gynecol Oncol 96(2):470–474

CAS  PubMed  Google Scholar 

Mulder FI, Horvàth-Puhó E, van Es N, Van Laarhoven H, Pedersen L, Moik F, Ay C, Büller H, Sørensen H (2021) Venous thromboembolism in cancer patients: a population-based cohort study, blood. J Am Soc Hematol 137(14):1959–1969

CAS  Google Scholar 

Howe K.L., Achuthan P., Allen J., Allen J., Alvarez-Jarreta J., Amode M.R., Armean I.M., Azov A.G., Bennett R., Bhai J. (2021) Ensembl 2021. Nucleic Acids Res 49D1:D884–D891

Ju H, Lim B, Kim M, Noh SM, Kim WH, Ihm C, Choi BY, Kim YS, Kang C (2010) SERPINE1 intron polymorphisms affecting gene expression are associated with diffuse-type gastric cancer susceptibility. Cancer 116(18):4248–4255

CAS  PubMed  Google Scholar 

Siokas V, Dardiotis E, Sokolakis T, Kotoula M, Tachmitzi SV, Chatzoulis DZ, Almpanidou P, Stefanidis I, Hadjigeorgiou GM, Tsironi EE (2017) Plasminogen activator inhibitor type-1 tag single-nucleotide polymorphisms in patients with diabetes mellitus type 2 and diabetic retinopathy. Curr Eye Res 42(7):1048–1053

CAS  PubMed  Google Scholar 

Williams PT (2021) Quantile-specific heritability of plasminogen activator inhibitor type‐1 (PAI‐1, aka SERPINE1) and other hemostatic factors. J Thromb Haemost 19(10):2559–2571

CAS  PubMed  Google Scholar 

Zhang P, Chaldebas M, Ogishi M, Al Qureshah F, Ponsin K, Feng Y, Rinchai D, Milisavljevic B, Han JE, Moncada-Vélez M (2023) Genome-wide detection of human intronic AG-gain variants located between splicing branchpoints and canonical splice acceptor sites. Proc Natl Acad Sci 120(46):e2314225120

CAS  PubMed  PubMed Central  Google Scholar 

Johnson DC, Corthals S, Ramos C, Hoering A, Cocks K, Dickens NJ, Haessler J, Goldschmidt H, Child JA, Bell SE (2008) Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping, blood. J Am Soc Hematol 112(13):4924–4934

CAS  Google Scholar 

Furuya H, Sasaki Y, Chen R, Peres R, Hokutan K, Murakami K, Kim N, Chan OT, Pagano I, Dyrskjøt L (2022) PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity. Sci Rep 12(1):12186

CAS  PubMed  PubMed Central  Google Scholar 

Al-Amer OM (2022) The role of thrombin in haemostasis. Blood Coagul Fibrinolysis 33(3):145–148

CAS  PubMed  Google Scholar 

Reddel CJ, Tan CW, Chen VM (2019) Thrombin generation and cancer: contributors and consequences. Cancers 11(1):100

CAS  PubMed  PubMed Central  Google Scholar 

Ünlü B, Versteeg HH (2014) Effects of tumor-expressed coagulation factors on cancer progression and venous thrombosis: is there a key factor? Thromb Res 133:S76–S84

PubMed  Google Scholar 

Steri M, Idda ML, Whalen MB, Orrù V (2018) Genetic variants in mRNA untranslated regions. Wiley Interdisciplinary Reviews: RNA 9(4):e1474

PubMed  Google Scholar 

Demirci FYK, Dressen AS, Kammerer CM, Barmada MM, Kao AH, Ramsey-Goldman R, Manzi S, Kamboh MI (2011) Functional polymorphisms of the coagulation factor II gene (F2) and susceptibility to systemic lupus erythematosus. J Rhuematol 38(4):652–657

Google Scholar 

Trégouët DA, Morange PE (2018) What is currently known about the genetics of venous thromboembolism at the dawn of next generation sequencing technologies. Br J Haematol 180(3):335–345

PubMed  Google Scholar 

Xia X, Fu J, Wu T, Chen W, Jiang S, Lv M, Zhang J (2022) Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin. Eur J Clin Pharmacol 1–10

Vossen CY, Hoffmeister M, Chang-Claude JC, Rosendaal FR, Brenner H

Comments (0)

No login
gif