Estimating the prevalence and clinical causality of obstructive sleep apnea in paediatric narcolepsy patients

Bassetti CLA, Adamantidis A, Burdakov D et al (2019) Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nat Rev Neurol 15(9):519–539

Article  PubMed  Google Scholar 

Maski K, Owens JA (2016) Insomnia, parasomnias, and narcolepsy in children: clinical features, diagnosis, and management. Lancet Neurol 15(11):1170–1181

Article  PubMed  Google Scholar 

Kornum BR, Knudsen S, Ollila HM et al (2017) Narcolepsy. Nat Rev Dis Primers 3:16100

Article  PubMed  Google Scholar 

Sateia MJ (2014) International classification of sleep disorders-third edition: highlights and modifications. Chest 146(5):1387–1394

Article  PubMed  Google Scholar 

Mahoney CE, Cogswell A, Koralnik IJ, Scammell TE (2019) The neurobiological basis of narcolepsy. Nat Rev Neurosci 20(2):83–93

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liblau RS, Latorre D, Kornum BR, Dauvilliers Y, Mignot EJ (2023) The immunopathogenesis of narcolepsy type 1. Nat Rev Immunol

Gao X, Wei T, Wang H et al (2023) Causal associations between obstructive sleep apnea and COVID-19: a bidirectional mendelian randomization study. Sleep Med 101:28–35

Article  PubMed  Google Scholar 

McEvoy RD, Antic NA, Heeley E et al (2016) CPAP for Prevention of Cardiovascular Events in obstructive sleep apnea. N Engl J Med 375(10):919–931

Article  PubMed  Google Scholar 

Gottlieb DJ, Punjabi NM (2020) Diagnosis and management of obstructive sleep apnea: a review. JAMA 323(14):1389–1400

Article  PubMed  Google Scholar 

Sansa G, Iranzo A, Santamaria J (2010) Obstructive sleep apnea in narcolepsy. Sleep Med 11(1):93–95

Article  PubMed  Google Scholar 

Alakuijala A, Sarkanen T, Jokela T, Partinen M (2021) Accuracy of Actigraphy compared to concomitant ambulatory polysomnography in Narcolepsy and other Sleep disorders. Front Neurol 12:629709

Article  PubMed  PubMed Central  Google Scholar 

Quaedackers L, Pillen S, Overeem S (2021) Recognizing the Symptom Spectrum of Narcolepsy to Improve Timely diagnosis: a narrative review. Nat Sci Sleep 13:1083–1096

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Haycock PC, Burgess S (2016) Consistent estimation in mendelian randomization with some Invalid instruments using a weighted median estimator. Genet Epidemiol 40(4):304–314

Article  PubMed  PubMed Central  Google Scholar 

Bulik-Sullivan B, Finucane HK, Anttila V et al (2015) An atlas of genetic correlations across human diseases and traits. Nat Genet 47(11):1236–1241

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bulik-Sullivan BK, Loh PR, Finucane HK et al (2015) LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 47(3):291–295

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burgess S, Butterworth A, Thompson SG (2013) Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 37(7):658–665

Article  PubMed  PubMed Central  Google Scholar 

Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey Smith G (2008) Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med 27(8):1133–1163

Article  PubMed  Google Scholar 

Ioannidis JP, Haidich AB, Pappa M et al (2001) Comparison of evidence of treatment effects in randomized and nonrandomized studies. JAMA 286(7):821–830

Article  CAS  PubMed  Google Scholar 

Palmer TM, Lawlor DA, Harbord RM et al (2012) Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res 21(3):223–242

Article  PubMed  PubMed Central  Google Scholar 

Li S, Xu Y, Zhang Y et al (2020) Mendelian randomization analyses of genetically predicted circulating levels of cytokines with risk of breast cancer. NPJ Precis Oncol 4:25

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kerkhof GA, Geuke ME, Brouwer A, Rijsman RM, Schimsheimer RJ, Van Kasteel V (2013) Holland Sleep Disorders Questionnaire: a new sleep disorders questionnaire based on the International classification of Sleep Disorders-2. J Sleep Res 22(1):104–107

Article  PubMed  Google Scholar 

Berry RB, Budhiraja R, Gottlieb DJ et al (2012) Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated events. Deliberations of the Sleep Apnea definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med 8(5):597–619

Article  PubMed  PubMed Central  Google Scholar 

Chen L, Ma W, Tang W et al (2020) Prevalence of obstructive sleep apnea in patients with Diabetic Foot Ulcers. Front Endocrinol (Lausanne) 11:416

Article  CAS  PubMed  Google Scholar 

Ho V, Crainiceanu CM, Punjabi NM, Redline S, Gottlieb DJ (2015) Calibration model for apnea-hypopnea indices: impact of Alternative Criteria for Hypopneas. Sleep 38(12):1887–1892

Article  PubMed  PubMed Central  Google Scholar 

Sanderson E, Spiller W, Bowden J (2021) Testing and correcting for weak and pleiotropic instruments in two-sample multivariable mendelian randomization. Stat Med 40(25):5434–5452

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Thompson SG, Collaboration CCG (2011) Avoiding bias from weak instruments in mendelian randomization studies. Int J Epidemiol 40(3):755–764

Article  PubMed  Google Scholar 

Strausz S, Ruotsalainen S, Ollila HM et al (2021) Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health. Eur Respir J ;57(5)

Jin Y (2023) Causal relationship between narcolepsy and depression: a two-sample mendelian randomization study. J Psychosom Res 175:111517

Article  PubMed  Google Scholar 

Hemani G, Zheng J, Elsworth B et al (2018) The MR-Base platform supports systematic causal inference across the human phenome. Elife ;7

Verbanck M, Chen CY, Neale B, Do R (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases. Nat Genet 50(5):693–698

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sahni AS, Carlucci M, Malik M, Prasad B (2019) Management of excessive sleepiness in patients with Narcolepsy and OSA: current challenges and future prospects. Nat Sci Sleep 11:241–252

Article  PubMed  PubMed Central  Google Scholar 

Broughton RJ, Fleming JA, George CF et al (1997) Randomized, double-blind, placebo-controlled crossover trial of modafinil in the treatment of excessive daytime sleepiness in narcolepsy. Neurology 49(2):444–451

Article  CAS  PubMed  Google Scholar 

Malhotra A, Strollo PJ Jr., Pepin JL et al (2022) Effects of solriamfetol treatment on body weight in participants with obstructive sleep apnea or narcolepsy. Sleep Med 100:165–173

Article  PubMed  PubMed Central  Google Scholar 

Jin T, Huang W, Cao F et al (2022) Causal association between systemic lupus erythematosus and the risk of dementia: a mendelian randomization study. Front Immunol 13:1063110

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scammell TE, Narcolepsy (2015) N Engl J Med 373(27):2654–2662

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