Unraveling the Endocannabinoid System: Exploring Its Therapeutic Potential in Autism Spectrum Disorder

Aishworiya, R., Valica, T., Hagerman, R., & Restrepo, B. (2022). An update on psychopharmacological treatment of autism spectrum disorder. Neurotherapeutics, 19(1), 248–262. https://doi.org/10.1007/s13311-022-01183-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aran, A., Eylon, M., Harel, M., Polianski, L., Nemirovski, A., Tepper, S., Schnapp, A., Cassuto, H., Wattad, N., & Tam, J. (2019). Lower circulating endocannabinoid levels in children with autism spectrum disorder. Molecular Autism, 10(1), 1–11.

Article  Google Scholar 

Atwood, B. K., & Mackie, K. (2010). CB2: A cannabinoid receptor with an identity crisis. British Journal of Pharmacology, 160(3), 467–479.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Atwood, B. K., Straiker, A., & Mackie, K. (2012a). CB2: Therapeutic target-in-waiting. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 38(1), 16–20. https://doi.org/10.1016/j.pnpbp.2011.12.001

Article  CAS  PubMed  Google Scholar 

Atwood, B. K., Wager-Miller, J., Haskins, C., Straiker, A., & Mackie, K. (2012b). Functional selectivity in CB2 cannabinoid receptor signaling and regulation: Implications for the therapeutic potential of CB2 ligands. Molecular Pharmacology, 81(2), 250–263.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bailone, R. L., Fukushima, H. C. S., De Aguiar, L. K., & Borra, R. C. (2022). The endocannabinoid system in Zebrafish and its potential to study the effects of Cannabis in humans. Laboratory Animal Research, 38(1), 1–12.

Article  Google Scholar 

Baron-Cohen, S. (2004). Autism: Research into causes and intervention. Pediatric Rehabilitation, 7(2), 73–78.

Article  PubMed  Google Scholar 

Berghuis, P., Rajnicek, A. M., Morozov, Y. M., Ross, R. A., Mulder, J., Urbán, G. M., Monory, K., Marsicano, G., Matteoli, M., Canty, A., Irving, A. J., Katona, I., Yanagawa, Y., Rakic, P., Lutz, B., Mackie, K., & Harkany, T. (2007). Hardwiring the brain: Endocannabinoids shape neuronal connectivity. Science, 316(5828), 1212–1216. https://doi.org/10.1126/science.1137406

Article  CAS  PubMed  Google Scholar 

Bou Khalil, R. (2012). Would some cannabinoids ameliorate symptoms of autism? European Child & Adolescent Psychiatry, 21(4), 237–238.

Article  Google Scholar 

Busquets-Garcia, A., Gomis-González, M., Guegan, T., Agustín-Pavón, C., Pastor, A., Mato, S., Pérez-Samartín, A., Matute, C., De La Torre, R., & Dierssen, M. (2013). Targeting the endocannabinoid system in the treatment of fragile X syndrome. Nature Medicine, 19(5), 603–607.

Article  CAS  PubMed  Google Scholar 

Carrier, E. J., Kearn, C. S., Barkmeier, A. J., Breese, N. M., Yang, W., Nithipatikom, K., Pfister, S. L., Campbell, W. B., & Hillard, C. J. (2004). Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. Molecular Pharmacology, 65(4), 999–1007. https://doi.org/10.1124/mol.65.4.999

Article  CAS  PubMed  Google Scholar 

Chakrabarti, B., Kent, L., Suckling, J., Bullmore, E., & Baron-Cohen, S. (2006). Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces. European Journal of Neuroscience, 23(7), 1944–1948.

Article  PubMed  Google Scholar 

Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997). Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits. Proceedings of the National Academy of Sciences USA, 94(10), 5401–5404.

Article  CAS  Google Scholar 

Cording, K. R., & Bateup, H. S. (2023). Altered motor learning and coordination in mouse models of autism spectrum disorder. Frontiers in Cellular Neuroscience, 17, 1270489. https://doi.org/10.3389/fncel.2023.1270489

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cristino, L., Bisogno, T., & Di Marzo, V. (2020). Cannabinoids and the expanded endocannabinoid system in neurological disorders. Nature Reviews Neurology, 16(1), 9–29. https://doi.org/10.1038/s41582-019-0284-z

Article  PubMed  Google Scholar 

Di Marco, B., Bonaccorso, C. M., Aloisi, E., Antoni, S., & Catania, M. V. (2016). Neuro-inflammatory mechanisms in developmental disorders associated with intellectual disability and autism spectrum disorder: A neuro-immune perspective. CNS & Neurological Disorders-Drug Targets, 15(4), 448–463.

Article  Google Scholar 

Do, Y., McKallip, R. J., Nagarkatti, M., & Nagarkatti, P. S. (2004). Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: Novel role for endogenous and exogenous cannabinoids in immunoregulation. The Journal of Immunology, 173(4), 2373–2382. https://doi.org/10.4049/jimmunol.173.4.2373

Article  CAS  PubMed  Google Scholar 

Doenni, V. M., Gray, J. M., Song, C. M., Patel, S., Hill, M. N., & Pittman, Q. J. (2016). Deficient adolescent social behavior following early-life inflammation is ameliorated by augmentation of anandamide signaling. Brain, Behavior, and Immunity, 58, 237–247. https://doi.org/10.1016/j.bbi.2016.07.152

Article  CAS  PubMed  PubMed Central  Google Scholar 

Domschke, K., Dannlowski, U., Ohrmann, P., Lawford, B., Bauer, J., Kugel, H., Heindel, W., Young, R., Morris, P., & Arolt, V. (2008). Cannabinoid receptor 1 (CNR1) gene: Impact on antidepressant treatment response and emotion processing in major depression. European Neuropsychopharmacology, 18(10), 751–759.

Article  CAS  PubMed  Google Scholar 

Efron, D., & Taylor, K. (2023). Medicinal Cannabis for paediatric developmental, behavioural and mental health disorders. International Journal of Environmental Research and Public Health, 20(8), 5430.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elphick, M. R. (2012). The evolution and comparative neurobiology of endocannabinoid signalling. Philosophical Transactions of the Royal Society b: Biological Sciences, 367(1607), 3201–3215.

Article  CAS  Google Scholar 

Etherton, M., Földy, C., Sharma, M., Tabuchi, K., Liu, X., Shamloo, M., Malenka, R. C., & Südhof, T. C. (2011). Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proceedings of the National Academy of Sciences USA, 108(33), 13764–13769.

Article  CAS  Google Scholar 

Fingerle-Rowson, G. R., & Bucala, R. (2001). Neuroendocrine properties of macrophage migration inhibitory factor (MIF). Immunology and Cell Biology, 79(4), 368–375. https://doi.org/10.1046/j.1440-1711.2001.01024.x

Article  CAS  PubMed  Google Scholar 

Fong, T. M., & Heymsfield, S. B. (2009). Cannabinoid-1 receptor inverse agonists: Current understanding of mechanism of action and unanswered questions. International Journal of Obesity, 33(9), 947–955. https://doi.org/10.1038/ijo.2009.132

Article  CAS  PubMed  Google Scholar 

Freund, T. F., Katona, I., & Piomelli, D. (2003). Role of endogenous cannabinoids in synaptic signaling. Physiological Reviews, 83(3), 1017–1066. https://doi.org/10.1152/physrev.00004.2003

Article  CAS  PubMed  Google Scholar 

Garber, K. B., Visootsak, J., & Warren, S. T. (2008). Fragile X syndrome. European Journal of Human Genetics, 16(6), 666–672.

Article  CAS  PubMed  Google Scholar 

Garcia-Gutierrez, M. S., Navarrete, F., Navarro, G., Reyes-Resina, I., Franco, R., Lanciego, J. L., Giner, S., Manzanares, J. (2018). Alterations in gene and protein expression of cannabinoid cb2 and gpr55 receptors in the dorsolateral prefrontal cortex of suicide victims. Neurotherapeutics. (2018) 15, 796–806. https://doi.org/10.1007/s13311-018-0610-y

Article  Google Scholar 

Geschwind, D. H. (2008). Autism: Many genes, common pathways? Cell, 135(3), 391–395. https://doi.org/10.1016/j.cell.2008.10.016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., & Stanley, E. R. (2010). Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science, 330(6005), 841–845.

Article  CAS  PubMed  PubMed Central 

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