Bai S, Guo W, Feng Y, Deng H, Li G, Nie H, Guo G, Yu H, Ma Y, Wang J, Chen S, Jing J, Yang J, Tang Y, Tang Z (2020) Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis of randomised controlled trials. J Neurol Neurosurg Psychiatry 91:21–32
Black PH (2006) The inflammatory consequences of psychologic stress: relationship to insulin resistance, obesity, atherosclerosis and diabetes mellitus, type II. Med Hypotheses 67:879–891
Article CAS PubMed Google Scholar
Bonne O, Gill JM, Luckenbaugh DA, Collins C, Owens MJ, Alesci S, Neumeister A, Yuan P, Kinkead B, Manji HK, Charney DS, Vythilingam M (2011) Corticotropin-releasing factor, interleukin-6, brain-derived neurotrophic factor, insulin-like growth factor-1, and substance P in the cerebrospinal fluid of civilians with posttraumatic stress disorder before and after treatment with paroxetine. J Clin Psychiatry 72:1124–1128
Article CAS PubMed Google Scholar
Boscarino JA (2004) Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies. Ann N Y Acad Sci 1032:141–153
Dahl J, Ormstad H, Aass HC, Sandvik L, Malt UF, Andreassen OA (2016) Recovery from major depressive disorder episode after non-pharmacological treatment is associated with normalized cytokine levels. Acta Psychiatr Scand 134:40–47
Article CAS PubMed Google Scholar
Dennis PA, Weinberg JB, Calhoun PS, Watkins LL, Sherwood A, Dennis MF, Beckham JC (2016) An investigation of vago-regulatory and health-behavior accounts for increased inflammation in posttraumatic stress disorder. J Psychosom Res 83:33–39
Article PubMed PubMed Central Google Scholar
Dinarello CA (2010) Anti-inflammatory agents: present and future. Cell 140:935–950
Article CAS PubMed PubMed Central Google Scholar
Gola H, Engler H, Sommershof A, Adenauer H, Kolassa S, Schedlowski M, Groettrup M, Elbert T, Kolassa IT (2013) Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells. BMC Psychiatry 13:40
Article CAS PubMed PubMed Central Google Scholar
Himmerich H, Willmund GD, Zimmermann P, Wolf JE, Buhler AH, Kirkby KC, Dalton B, Holdt LM, Teupser D, Wesemann U (2016) Serum concentrations of TNF-alpha and its soluble receptors during psychotherapy in German soldiers suffering from combat-related PTSD. Psychiatr Danub 28:293–298
Hori H, Yoshida F, Itoh M, Lin M, Niwa M, Ino K, Imai R, Ogawa S, Matsui M, Kamo T, Kunugi H, Kim Y (2020) Proinflammatory status-stratified blood transcriptome profiling of civilian women with PTSD. Psychoneuroendocrinology 111:104491
Article CAS PubMed Google Scholar
Jergovic M, Bendelja K, Savic Mlakar A, Vojvoda V, Aberle N, Jovanovic T, Rabatic S, Sabioncello A, Vidovic A (2015) Circulating levels of hormones, lipids, and immune mediators in post-traumatic stress disorder—a 3-month follow-up study. Front Psychiatry 6:49
Article PubMed PubMed Central Google Scholar
Kang BS, Chung EY, Yun YP, Lee MK, Lee YR, Lee KS, Min KR, Kim Y (2001) Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull 24:701–703
Article CAS PubMed Google Scholar
Kimerling R (2004) An investigation of sex differences in nonpsychiatric morbidity associated with posttraumatic stress disorder. J Am Med Womens Assoc 1972(59):43–47
Kobel F, Morawa E, Erim Y (2020) Effectiveness of inpatient psychotherapy for patients with and without migratory background: do they benefit equally? Front Psychiatry 11:542
Article PubMed PubMed Central Google Scholar
Koenen KC, Ratanatharathorn A, Ng L, McLaughlin KA, Bromet EJ, Stein DJ, Karam EG, Meron Ruscio A, Benjet C, Scott K, Atwoli L, Petukhova M, Lim CCW, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Bunting B, Ciutan M, de Girolamo G, Degenhardt L, Gureje O, Haro JM, Huang Y, Kawakami N, Lee S, Navarro-Mateu F, Pennell BE, Piazza M, Sampson N, Ten Have M, Torres Y, Viana MC, Williams D, Xavier M, Kessler RC (2017) Posttraumatic stress disorder in the world mental health surveys. Psychol Med 47:2260–2274
Article CAS PubMed PubMed Central Google Scholar
Kruger-Gottschalk A, Knaevelsrud C, Rau H, Dyer A, Schafer I, Schellong J, Ehring T (2017) The German version of the posttraumatic stress disorder checklist for DSM-5 (PCL-5): psychometric properties and diagnostic utility. BMC Psychiatry 17:379
Article PubMed PubMed Central Google Scholar
Langgartner D, Lowry CA, Reber SO (2018) Old friends, immunoregulation, and stress resilience. Pflugers Archiv Eur J Physiol 471:237–269
Löwe B, Spitzer RL, Zipfel S, Herzog W (2002) Gesundheitsfragebogen für Patienten (PHQ-D). Manual und Testunterlagen. 2. Auflage (PRIMEMD Patient Health Questionnaire (PHQ)—German version. Manual and materials, 2nd edn
Margraf J, Cwik JC, Pflug V, Schneider S (2017) Structured clinical interviews for mental disorders across the lifespan: psychometric quality and further developments of the DIPS Open Access interviews. [Strukturierte klinische Interviews zur Erfassung psychischer Störungen über die Lebensspanne: Gütekriterien und Weiterentwicklungen der DIPS-Verfahren.]. Z Klin Psychol Psychother 46:176–186
Nilsonne G, Hilgard J, Lekander M, Arnberg FK (2016) Post-traumatic stress disorder and interleukin 6. Lancet Psychiatry 3:200–201
Passos IC, Vasconcelos-Moreno MP, Costa LG, Kunz M, Brietzke E, Quevedo J, Salum G, Magalhaes PV, Kapczinski F, Kauer-Sant’Anna M (2015) Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression. Lancet Psychiatry 2:1002–1012
Philipps A, Silbermann A, Morawa E, Stemmler M, Erim Y (2019) Effectiveness of a multimodal, day clinic group-based treatment program for trauma-related disorders: differential therapy outcome for complex PTSD vs. non-complex trauma-related disorders. Front Psychiatry 10:800
Article PubMed PubMed Central Google Scholar
Raison CL, Miller AH (2003) When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry 160:1554–1565
R-Core-Team (2022) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria
Renner V, Joraschky P, Kirschbaum C, Schellong J, Petrowski K (2022) Pro- and anti-inflammatory cytokines Interleukin-6 and Interleukin-10 predict therapy outcome of female patients with posttraumatic stress disorder. Transl Psychiatry 12:472
Article CAS PubMed PubMed Central Google Scholar
Rhein C, Tripal P, Seebahn A, Konrad A, Kramer M, Nagel C, Kemper J, Bode J, Muhle C, Gulbins E, Reichel M, Becker CM, Kornhuber J (2012) Functional implications of novel human acid sphingomyelinase splice variants. PLoS One 7:e35467
Article CAS PubMed PubMed Central Google Scholar
Rhein C, Hepp T, Kraus O, von Majewski K, Lieb M, Rohleder N, Erim Y (2021) Interleukin-6 secretion upon acute psychosocial stress as a potential predictor of psychotherapy outcome in posttraumatic stress disorder. J Neural Transm (Vienna) 128:1301–1310
Article CAS PubMed Google Scholar
Rytila-Manninen M, Frojd S, Haravuori H, Lindberg N, Marttunen M, Kettunen K, Therman S (2016) Psychometric properties of the symptom checklist-90 in adolescent psychiatric inpatients and age- and gender-matched community youth. Child Adolesc Psychiatry Ment Health 10:23
Article PubMed PubMed Central Google Scholar
Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protocols 3:1101–1108
Article CAS PubMed Google Scholar
Speer K, Upton D, Semple S, McKune A (2018) Systemic low-grade inflammation in post-traumatic stress disorder: a systematic review. J Inflamm Res 11:111–121
Article PubMed PubMed Central Google Scholar
Toft H, Bramness JG, Lien L, Abebe DS, Wampold BE, Tilden T, Hestad K, Neupane SP (2018) PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress. Neuropsychiatr Dis Treat 14:2367–2378
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