Yamasaki T, Ikawa F, Hidaka T, Kuwabara M, Matsuda S, Ozono I, et al. Prevalence and risk factors for brain white matter changes in young and middle-aged participants with Brain Dock (brain screening): a registry database study and literature review. Aging (Albany NY). 2021;13:9496–509.

Article  PubMed  Google Scholar 

Huang P, Zhu Z, Zhang R, Wu X, Jiaerken Y, Wang S, et al. Factors associated with the dilation of perivascular space in healthy elderly subjects. Front Aging Neurosci. 2021;13: 624732.

Article  PubMed  PubMed Central  Google Scholar 

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med. 2012;4:147.

Article  Google Scholar 

Jessen NA, Munk AS, Lundgaard I, Nedergaard M. The glymphatic system: a beginner’s guide. Neurochem Res. 2015;40:2583–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X, Wang Y, Jiao B, Wang Z, Shi J, Zhang Y, et al. Glymphatic system impairment in Alzheimer’s disease: associations with perivascular space volume and cognitive function. Eur Radiol. 2024;34:1314–23.

Article  CAS  PubMed  Google Scholar 

Zhang W, Zhou Y, Wang J, Gong X, Chen Z, Zhang X, et al. Glymphatic clearance function in patients with cerebral small vessel disease. Neuroimage. 2021;238: 118257.

Article  PubMed  Google Scholar 

Cannistraro RJ, Badi M, Eidelman BH, Dickson DW, Middlebrooks EH, Meschia JF. CNS small vessel disease: a clinical review. Neurology. 2019;92:1146–56.

Article  PubMed  PubMed Central  Google Scholar 

Duering M, Biessels GJ, Brodtmann A, Chen C, Cordonnier C, de Leeuw FE, Debette S, et al. Neuroimaging standards for research into small vessel disease-advances since 2013. Lancet Neurol. 2023;22:602–18.

Article  PubMed  Google Scholar 

Klarenbeek P, van Oostenbrugge RJ, Lodder J, Rouhl RP, Knottnerus IL, Staals J. Higher ambulatory blood pressure relates to enlarged Virchow-Robin spaces in first-ever lacunar stroke patients. J Neurol. 2013;260:115–21.

Article  PubMed  Google Scholar 

Martinez-Ramirez S, Pontes-Neto OM, Dumas AP, Auriel E, Halpin A, Quimby M, et al. Topography of dilated perivascular spaces in subjects from a memory clinic cohort. Neurology. 2013;80:1551–6.

Article  PubMed  PubMed Central  Google Scholar 

Ballerini L, Booth T, Valdés Hernández MDC, Wiseman S, Lovreglio R, Muñoz Maniega S, et al. Computational quantification of brain perivascular space morphologies: associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936. Neuroimage Clin. 2020;25:102120.

Article  PubMed  Google Scholar 

Hurford R, Charidimou A, Fox Z, Cipolotti L, Jager R, Werring DJ. MRI-visible perivascular spaces: relationship to cognition and small vessel disease MRI markers in ischaemic stroke and TIA. J Neurol Neurosurg Psychiatry. 2014;85:522–5.

Article  PubMed  Google Scholar 

Khan U, Porteous L, Hassan A, Markus HS. Risk factor profile of cerebral small vessel disease and its subtypes. J Neurol Neurosurg Psychiatry. 2007;78:702–6.

Article  PubMed  PubMed Central  Google Scholar 

Hilal S, Mok V, Youn YC, Wong A, Ikram MK, Chen CL. Prevalence, risk factors and consequences of cerebral small vessel diseases: data from three Asian countries. J Neurol Neurosurg Psychiatry. 2017;88:669–74.

Article  PubMed  Google Scholar 

Doubal FN, MacLullich AM, Ferguson KJ, Dennis MS, Wardlaw JM. Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease. Stroke. 2010;41:450–4.

Article  PubMed  Google Scholar 

Potter GM, Doubal FN, Jackson CA, Chappell FM, Sudlow CL, Dennis MS, et al. Enlarged perivascular spaces and cerebral small vessel disease. Int J Stroke. 2015;10:376–81.

Article  PubMed  Google Scholar 

Patankar TF, Mitra D, Varma A, Snowden J, Neary D, Jackson A. Dilatation of the Virchow-Robin space is a sensitive indicator of cerebral microvascular disease: study in elderly patients with dementia. Am J Neuroradiol. 2005;26:1512–20.

PubMed  PubMed Central  Google Scholar 

Hansen TP, Cain J, Thomas O, Jackson A. Dilated perivascular spaces in the basal ganglia are a biomarker of small-vessel disease in a very elderly population with dementia. Am J Neuroradiol. 2015;36:893–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evans NR, Tarkin JM, Walsh J, Chowdhury MM, Patterson AJ, Graves MJ, et al. Carotid atheroinflammation is associated with cerebral small vessel disease severity. Front Neurol. 2021;12: 690935.

Article  PubMed  PubMed Central  Google Scholar 

Iseki C, Kawanami T, Nagasawa H, Wada M, Koyama S, Kikuchi K, et al. Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM) in the elderly: a prospective study in a Japanese population. J Neurol Sci. 2009;277:54–7.

Article  PubMed  Google Scholar 

Zhu YC, Tzourio C, Soumaré A, Mazoyer B, Dufouil C, Chabriat H. Severity of dilated Virchow-Robin spaces is associated with age, blood pressure, and MRI markers of small vessel disease: a population-based study. Stroke. 2010;41:2483–90.

Article  PubMed  Google Scholar 

Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. Am J Roentgenol. 1987;149:351–6.

Article  CAS  Google Scholar 

Staals J, Makin SD, Doubal FN, Dennis MS, Wardlaw JM. Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden. Neurology. 2014;83:1228–34.

Article  PubMed  PubMed Central  Google Scholar 

Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74.

Article  CAS  PubMed  Google Scholar 

Giese AK, Schirmer MD, Dalca AV, Sridharan R, Donahue KL, Nardin M, et al. White matter hyperintensity burden in acute stroke patients differs by ischemic stroke subtype. Neurology. 2020;95:e79-88.

Article  PubMed  PubMed Central  Google Scholar 

Longstreth WT Jr, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke. 1996;27:1274–82.

Article  PubMed  Google Scholar 

Jeerakathil T, Wolf PA, Beiser A, Massaro J, Seshadri S, D’Agostino RB, et al. Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study. Stroke. 2004;35:1857–61.

Article  PubMed  Google Scholar 

Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48:452–8.

Article  CAS  PubMed  Google Scholar 

Del Brutto OH, Mera RM, Costa AF, Rumbea DA, Recalde BY, Del Brutto VJ. Patterns of progression of cerebral small vessel disease markers in older adults of Amerindian ancestry: a population-based, longitudinal prospective cohort study. Aging Clin Exp Res. 2022;34:2751–9.

Article  PubMed  PubMed Central  Google Scholar 

Yang S, Qin W, Yang L, Fan H, Li Y, Yin J, et al. The relationship between ambulatory blood pressure variability and enlarged perivascular spaces: a cross-sectional study. BMJ Open. 2017;7: e015719.

Article  PubMed  PubMed Central  Google Scholar 

Yang H, Fan X, Shen X, Liang L, Hu D, Zhang Y, et al. Correlation of blood pressure levels at different time periods throughout the day with total CSVD burden and MRI imaging markers. Front Neurol. 2023;14:1200846.

Article  PubMed  PubMed Central  Google Scholar 

Mancia G, Verdecchia P. Clinical value of ambulatory blood pressure: evidence and limits. Circ Res. 2015;116:1034–45.

Article  CAS