Plasminogen activator inhibitor-1 is involved in glucocorticoid-induced decreases in angiogenesis during bone repair in mice

Hofbauer LC, Minireview M, Rauner A (2009) Live and let die: molecular effects of glucocorticoids on bone cells. Mol Endocrinol 10:1525–1531

Article  Google Scholar 

McInnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365:2205–2219

Article  CAS  PubMed  Google Scholar 

Rhen T, Cidlowski JA (2005) Antiinflammatory action of glucocorticoids–new mechanisms for old drugs. N Engl J Med 353:1711–1723

Article  CAS  PubMed  Google Scholar 

Strehl C, Buttgereit F (2013) Optimized glucocorticoid therapy: teaching old drugs new tricks. Mol Cell Endocrinol 380:32–40

Article  CAS  PubMed  Google Scholar 

Hachemi Y, Rapp AE, Picke AK, Weidinger G, Ignatius A, Tuckermann J (2018) Molecular mechanisms of glucocorticoids on skeletal and bone regeneration after fracture. J Mol Endocrinol 61:R75-90

Article  CAS  PubMed  PubMed Central  Google Scholar 

Henneicke H, Gasparini SJ, Brennan-Speranza TC, Zhou H, Seibel MJ (2014) Glucocorticoids and bone: local effects and systemic implications. Trends Endocrinol Metab 25:197–211

Article  CAS  PubMed  Google Scholar 

Moutsatsou P, Kassi E, Papavassiliou AG (2012) Glucocorticoid receptor signaling in bone cells. Trends Mol Med 18:348–359

Article  CAS  PubMed  Google Scholar 

Okada K, Okamoto T, Okumoto K, Takafuji Y, Ishida M, Kawao N, Matsuo O, Kaji H (2020) PAI-1 is involved in delayed bone repair induced by glucocorticoids in mice. Bone 134:115310

Article  CAS  PubMed  Google Scholar 

Okada K, Kawao N, Nakai D, Wakabayashi R, Horiuchi Y, Okumoto K, Kurashimo S, Takafuji Y, Matsuo O, Kaji H (2022) Role of macrophages and plasminogen activator inhibitor-1 in delayed bone repair induced by glucocorticoids in mice. Int J Mol Sci 23:478

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen M, Li Y, Huang X, Gu Y, Li S, Yin P, Zhang L, Tang P (2021) Skeleton-vasculature chain reaction: a novel insight into the mystery of homeostasis. Bone Res 9:21

Article  PubMed  PubMed Central  Google Scholar 

Claes L, Recknagel S, Ignatius A (2012) Fracture healing under healthy and inflammatory conditions. Nat Rev Rheumatol 8:133–143

Article  CAS  PubMed  Google Scholar 

Bahney CS, Zondervan RL, Allison P, Theologis A, Ashley JW, Ahn J, Miclau T, Marcuclo RS, Hankenson AD (2019) Cellular biology of fracture healing. J Orthop Res 37:35–50

Article  PubMed  Google Scholar 

Fusumbe AP, Ramasamy SK, Adams RH (2014) Coupling of angiogenesis and osteogenesis by a apecific vessel stbtype in bone. Nature 507:323–328

Article  Google Scholar 

Ramasamy SK, Kusumbe AP, Wang L, Adains RH (2014) Endothlial Notch activity promotes angiogenesis osteogenesis in bone. Nature 507:376–380

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawao N, Tamura Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H (2013) Plasminogen plays a crucial role in bone repair. J Bone Miner Res 28:1561–1574

Article  CAS  PubMed  Google Scholar 

Kawao N, Tamura Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H (2014) Tissue-type plasminogen activator deficiency delays bone repair: roles of osteoblast proliferation and vascular endothelial growth factor. Am J Physiol Endocrinol Metab 307:E278–E288

Article  CAS  PubMed  Google Scholar 

Kawao N, Tamura Y, Horiuchi Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H (2015) The tissue fibrinolytic system contributes to the induction of macrophage function and CCL3 during bone repair in mice. PLoS ONE 10:e012398

Article  Google Scholar 

Okada K, Kawao N, Tatsumi K, Ishida M, Takafuji Y, Kurashimo S, Okumoto K, Kojima K, Matsuo O, Kaji H (2018) Roles of plasminogen in the alterations in bone marrow hematopoietic stem cells during bone repair. Bone Reports 8:195–203

Article  PubMed  PubMed Central  Google Scholar 

Kaji H (2016) Adipose tissue-derived plasminogen activator inhibitor-I function and regulation. Comp Physiol 6:1873–1896

Article  Google Scholar 

Mao L, Kawao N, Tamura Y, Okumoto K, Okada K, Yano M, Matsuo O, Kaji H (2014) Plasminogen activator inhibitor-1 is involved in impaired bone repair associated with diabetes in female mice. PLoS ONE 9:e92686

Article  PubMed  PubMed Central  Google Scholar 

Tamura Y, Kawao N, Okada K, Yano M, Okumoto K, Matsuo O, Kaji H (2013) Plasminogen activator inhibitor-1 is involved in streptozotocin-induced bone loss in female mice. Diabetes 62:3170–3179

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mao L, Tamura Y, Kawao N, Okada K, Yano M, Okumoto K, Kaji H (2014) Influence of diabetic state and vitamin D deficiency on bone repair in female mice. Bone 61:102–108

Article  CAS  PubMed  Google Scholar 

Schipani E, Maes C, Carmeliet G, Semenza GL (2009) Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. J Bone Miner Res 24:1347–1353

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deckers MM, van Bezooijen RL, van der Horst G, Hoogendam J, van Der Bent C, Papapoulos SE, Lowik CW (2002) Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology 143:1545–1553

Article  CAS  PubMed  Google Scholar 

Bostrom K, Zebboudj AF, Yao Y, Lin TS, Torres A, Matrix GL (2004) A protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells. J Biol Chem 279:52904–52913

Article  PubMed  Google Scholar 

Clifford RL, Deacon K, Knox AJ (2008) Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor β1: requirement for Smads, β-catenin, and GSK3β. J Biol Chem 283:35337–35353

Article  CAS  PubMed  Google Scholar 

Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH (2017) Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol 19:189–201

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng Y, Wu S, Li Y, Crane JL (2020) Type H blood vessels in bone modeling and remodeling. Theranostics 10:426–436

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramasamy SK, Kusumbe AP, Itkin T, Gur-Cohen S, Lapidot T, Adams RH (2016) Regulation of hematopoiesis and osteogenesis by blood vessel-derived signals. Annu Rev Cell Dev Biol 32:649–675

Article  CAS  PubMed  Google Scholar 

Karsenty G (2003) The complexities of skeletal biology. Nature 423:316–318

Article  CAS  PubMed  Google Scholar 

Peng Y, Shan L, Yusheng L, Jianxi Z, Shijie C, Gehua Z, Xu C, Song W, Janet LC (2020) Glucocorticoids disrupt skeletal angiogenesis through transrepression of NF-κB–mediated preosteoclast Pdgfb transcription in young mice. J Bone Miner Res 35:1188–1202

Article  CAS  PubMed 

Comments (0)

No login
gif