Abraham P, Sarkar R, Brandel MG, Wali AR, Rennert RC, Lopez Ramos C, Padwal J, Steinberg JA, Santiago-Dieppa DR, Cheung V, Pannell JS, Murphy JD, Khalessi AA (2019) Cost-effectiveness of Intraoperative MRI for treatment of high-Grade Gliomas. Radiology 291:689–697. https://doi.org/10.1148/radiol.2019182095

Article  PubMed  Google Scholar 

Bekelis K, Valdes PA, Erkmen K, Leblond F, Kim A, Wilson BC, Harris BT, Paulsen KD, Roberts DW (2011) Quantitative and qualitative 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in skull base meningiomas. Neurosurg Focus 30:E8. https://doi.org/10.3171/2011.2.FOCUS1112

Article  PubMed  PubMed Central  Google Scholar 

Chohan MO, Berger MS (2019) 5-Aminolevulinic acid fluorescence guided surgery for recurrent high-grade gliomas. J Neurooncol 141:517–522. https://doi.org/10.1007/s11060-018-2956-8

Article  CAS  PubMed  Google Scholar 

Coluccia D, Fandino J, Fujioka M, Cordovi S, Muroi C, Landolt H (2010) Intraoperative 5-aminolevulinic-acid-induced fluorescence in meningiomas. Acta Neurochir (Wien) 152:1711–1719. https://doi.org/10.1007/s00701-010-0708-4

Article  PubMed  Google Scholar 

Da Silva EB Jr, Ramina R, Coelho Neto M, Machado GAS, Cavalcanti MS, da Silva JFC (2019) Extending the indications of 5-Aminolevulinic acid for fluorescence-guided surgery for different Central Nervous System tumors: a Series of 255 cases in Latin America. Arq Bras Neurocir 41:e35–e42. https://doi.org/10.1055/s-0041-1739272

Article  Google Scholar 

Diez Valle R, Slof J, Galvan J, Arza C, Romariz C, Vidal C (2014) Observational, retrospective study of the effectiveness of 5-aminolevulinic acid in malignant glioma surgery in Spain (the VISIONA study). Neurologia 29:131–138

CAS  PubMed  Google Scholar 

Duarte JFS, Jung GS, da Silva EB Jr, de Almeida Teixeira BC, Cavalcanti MS, Ramina R (2022) 5-Aminolevulinic acid fluorescence in brain non-neoplastic lesions: a systematic review and case series. Neurosurg Rev 45:3139–3148. https://doi.org/10.1007/s10143-022-01843-y

Article  PubMed  Google Scholar 

Eljamel MS, Mahboob SO (2016) The effectiveness and cost-effectiveness of intraoperative imaging in high-grade glioma resection; a comparative review of intraoperative ALA, fluorescein, ultrasound and MRI. Photodiagnosis Photodyn Ther 16:35–43. https://doi.org/10.1016/j.pdpdt.2016.07.012

Article  PubMed  Google Scholar 

Esteves S, Alves M, Castel-Branco M, Stummer W (2015) A pilot cost-effectiveness analysis of treatments in newly diagnosed high-grade gliomas: the example of 5-aminolevulinic acid compared with white-light surgery. Neurosurgery 76:552–562. https://doi.org/10.1227/NEU.0000000000000673

Article  PubMed  Google Scholar 

Ferraro N, Barbarite E, Albert TR, Berchmans E, Shah AH, Bregy A, Ivan ME, Brown T, Komotar RJ (2016) The role of 5-aminolevulinic acid in brain tumor surgery: a systematic review. Neurosurg Rev 39:545–555. https://doi.org/10.1007/s10143-015-0695-2

Article  PubMed  Google Scholar 

Garfias Arjona S, Lara Almunia M, Ibáñez Domínguez JÁ, Delgado Sánchez O, Villalonga P, Villalonga-Planells R, Pierola Lopetegui J, Bestard Escalas J, Maimó Barceló A, Brell Doval M (2019) Comparison of commercial 5-aminolevulinic acid (Gliolan®) and the pharmacy-compounded solution fluorescence in glioblastoma. Acta Neurochir (Wien) 161:1733–1741. https://doi.org/10.1007/s00701-019-03930-4

Article  PubMed  Google Scholar 

Georges JF, Valeri A, Wang H, Brooking A, Kakareka M, Cho SS, Al-Atrache Z, Bamimore M, Osman H, Ifrach J, Yu S, Li C, Appelt D, Lee JYK, Nakaji P, Brill K, Yocom S (2019) Delta-Aminolevulinic acid-mediated photodiagnoses in Surgical Oncology: a historical review of clinical trials. Front Surg 6:45. https://doi.org/10.3389/fsurg.2019.00045

Article  PubMed  PubMed Central  Google Scholar 

Goel NJ, Bird CE, Hicks WH, Abdullah KG (2021) Economic implications of the modern treatment paradigm of glioblastoma: an analysis of global cost estimates and their utility for cost assessment. J Med Econ 24:1018–1024. https://doi.org/10.1080/13696998.2021.1964775

Article  PubMed  Google Scholar 

Hadjipanayis CG, Stummer W (2019) 5-ALA and FDA approval for glioma surgery. J Neurooncol 141:479–486. https://doi.org/10.1007/s11060-019-03098-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hadjipanayis CG, Widhalm G, Stummer W (2015) What is the Surgical Benefit of utilizing 5-Aminolevulinic acid for fluorescence-guided surgery of malignant gliomas? Neurosurgery 77:663– 73. https://doi.org/10.1227/NEU.0000000000000929

Haider SA, Lim S, Kalkanis SN, Lee IY (2019) The impact of 5-aminolevulinic acid on extent of resection in newly diagnosed high grade gliomas: a systematic review and single institutional experience. J Neurooncol 141:507–515. https://doi.org/10.1007/s11060-018-03061-3

Article  PubMed  Google Scholar 

Huang CY, Li JC, Chen KT, Lin YJ, Feng LY, Liu HL, Wei KC (2024) Evaluation the Effect of Sonodynamic Therapy with 5-Aminolevulinic acid and Sodium Fluorescein by Preclinical Animal Study. Cancers (Basel) 16:253. https://doi.org/10.3390/cancers16020253

Article  CAS  PubMed  Google Scholar 

Kamp MA, Fischer I, Bühner J, Turowski B, Cornelius JF, Steiger HJ, Rapp M, Slotty PJ, Sabel M (2016) 5-ALA fluorescence of cerebral metastases and its impact for the local-in-brain progression. Oncotarget 7:66776–66789. https://doi.org/10.18632/oncotarget.11488

Article  PubMed  PubMed Central  Google Scholar 

Kamp MA, Grosser P, Felsberg J, Slotty PJ, Steiger HJ, Reifenberger G, Sabel M (2012) 5-aminolevulinic acid (5-ALA)-induced fluorescence in intracerebral metastases: a retrospective study. Acta Neurochir (Wien) 154:223–228. https://doi.org/10.1007/s00701-011-1200-5

Article  PubMed  Google Scholar 

Kamp MA, Munoz-Bendix C, Mijderwijk HJ, Turowski B, Dibué-Adjei M, von Saß C, Cornelius JF, Steiger HJ, Rapp M, Sabel M (2019) Is 5-ALA fluorescence of cerebral metastases a prognostic factor for local recurrence and overall survival? J Neurooncol 141:547–553. https://doi.org/10.1007/s11060-018-03066-y

Article  CAS  PubMed  Google Scholar 

Lakomkin N, Hadjipanayis CG (2018) Fluorescence-guided surgery for high-grade gliomas. J Surg Oncol 118:356–361. https://doi.org/10.1002/jso.25154

Article  PubMed  Google Scholar 

Mansouri A, Mansouri S, Hachem LD, Klironomos G, Vogelbaum MA, Bernstein M, Zadeh G (2016) The role of 5-aminolevulinic acid in enhancing surgery for high-grade glioma, its current boundaries, and future perspectives: a systematic review. Cancer 122:2469–2478. https://doi.org/10.1002/cncr.30088

Article  PubMed  Google Scholar 

McCracken DJ, Schupper AJ, Lakomkin N, Malcolm J, Painton Bray D, Hadjipanayis CG (2022) Turning on the light for brain tumor surgery: a 5-aminolevulinic acid story. Neuro Oncol 24:S52–S61. https://doi.org/10.1093/neuonc/noac191

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mercea PA, Mischkulnig M, Kiesel B, Wadiura LI, Roetzer T, Prihoda R, Heicappell P, Kreminger J, Furtner J, Woehrer A, Preusser M, Roessler K, Berghoff AS, Widhalm G (2021) Prognostic value of 5-ALA fluorescence, Tumor Cell Infiltration and Angiogenesis in the Peritumoral Brain tissue of Brain metastases. Cancers (Basel) 13:603. https://doi.org/10.3390/cancers13040603

Article  CAS  PubMed  Google Scholar 

Millesi M, Kiesel B, Mischkulnig M, Martinez-Moreno M, Wohrer A, Wolfsberger S, Knosp E, Widhalm G (2016) Analysis of the surgical benefits of 5-ALA-induced fluorescence in intracranial meningiomas: experience in 204 meningiomas. J Neurosurg 125:1408–1419. https://doi.org/10.3171/2015.12.JNS151513

Article  CAS  PubMed  Google Scholar 

Ontario Health (Quality) (2020) 5-Aminolevulinic acid hydrochloride (5-ALA)-Guided Surgical Resection of High-Grade Gliomas: A Health Technology Assessment. Ont Health Technol Assess Ser 20:1–92

Google Scholar 

Raizer JJ, Fitzner KA, Jacobs DI, Bennett CL, Liebling DB, Luu TH, Trifilio SM, Grimm SA, Fisher MJ, Haleem MS, Ray PS, McKoy JM, DeBoer R, Tulas KM, Deeb M, McKoy JM (2015) Economics of malignant gliomas: a critical review. J Oncol Pract 11:e59–65. https://doi.org/10.1200/JOP.2012.000560

Article  PubMed  Google Scholar 

Ramina R, Coelho Neto M, Giacomelli A, Barros E Jr, Vosgerau R, Nascimento A, Coelho G (2010) Optimizing costs of intraoperative magnetic resonance imaging. A series of 29 glioma cases. Acta Neurochir (Wien) 152:27–33. https://doi.org/10.1007/s00701-009-0430-2

Article  PubMed  Google Scholar 

Ramina R, da Silva EB Jr, Constanzo F, Coelho Neto M (2018) Indications of 5-Aminolevulinic acid and intraoperative MRI in glioma surgery: first cases in Latin America in a single reference Center. Arq Bras Neurocir 37:088–094. https://doi.org/10.1055/s-0038-1667182

Article  Google Scholar 

Raw AS, Lionberger R, Yu LX (2011) Pharmaceutical equivalen