Ader R, Cohen N (1975) Behaviorally conditioned immunosuppression. Psychosom Med 37:333–340
Article CAS PubMed Google Scholar
Ader R, Cohen N (1993) Psychoneuroimmunology: conditioning and stress. Annu Rev Psychol 44:53–85
Article CAS PubMed Google Scholar
Albring A, Wendt L, Benson S, Nissen S, Yavuz Z, Engler H, Witzke O, Schedlowski M (2014) Preserving learned immunosuppressive placebo response: perspectives for clinical application. Clin Pharmacol Ther 96:247–255
Article CAS PubMed Google Scholar
Bovbjerg D, Kim YT, Siskind GW, Weksler ME (1987) Conditioned suppression of plaque-forming cell responses with cyclophosphamide. The role of taste aversion. Ann N Y Acad Sci 496:588–594
Article CAS PubMed Google Scholar
Brinkmann V (2009) FTY720 (fingolimod) in multiple sclerosis: therapeutic effects in the immune and the central nervous system. Br J Pharmacol 158:1173–1182
Article CAS PubMed PubMed Central Google Scholar
Brinkmann V, Billich A, Baumruker T, Heining P, Schmouder R, Francis G, Aradhye S, Burtin P (2010) Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat Rev Drug Discov 9:883–897
Article CAS PubMed Google Scholar
Chun J, Giovannoni G, Hunter SF (2021) Sphingosine 1-phosphate receptor modulator therapy for multiple sclerosis: Differential downstream receptor signalling and clinical Profile effects. Drugs 81:207–231
Article CAS PubMed Google Scholar
Cipriani R, Chara JC, Rodríguez-Antigüedad A, Matute C (2017) Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury. J Neuroinflammation 14:147
Article PubMed PubMed Central Google Scholar
Cuello AC, Carson S (1983) Microdissection of fresh rat brain tissue slices. Brain Microdissection Techniques. Wiley, pp 37–125
Dumont FJ, Su Q (1996) Mechanism of action of the immunosuppressant rapamycin. Life Sci 58:373–395
Article CAS PubMed Google Scholar
Eikelboom R, Stewart J (1982) Conditioning of Drug-Induced physiological responses. Psychol Rev 89:507–528
Article CAS PubMed Google Scholar
Exton MS, Schult M, Donath S, Strubel T, Bode U, del Rey A, Westermann J, Schedlowski M (1999) Conditioned immunosuppression makes subtherapeutic cyclosporin effective via splenic innervation. Am J Physiol 276:R1710–1717
Exton MS, Gierse C, Meier B, Mosen M, Xie Y, Frede S, Goebel MU, Limmroth V, Schedlowski M (2002) Behaviorally conditioned immunosuppression in the rat is regulated via noradrenaline and beta-adrenoceptors. J Neuroimmunol 131:21–30
Article CAS PubMed Google Scholar
Gajofatto A, Turatti M, Monaco S, Benedetti MD (2015) Clinical efficacy, safety, and tolerability of fingolimod for the treatment of relapsing-remitting multiple sclerosis. Drug Healthc Patient Saf 7:157–167
Article CAS PubMed PubMed Central Google Scholar
Goebel MU, Trebst AE, Steiner J, Xie YF, Exton MS, Frede S, Canbay AE, Michel MC, Heemann U, Schedlowski M (2002) Behavioral conditioning of immunosuppression is possible in humans. FASEB J 16:1869–1873
Article CAS PubMed Google Scholar
Gorczynski RM, Kennedy M (1987) Behavioral trait associated with conditioned immunity. Brain Behav Immun 1:72–80
Article CAS PubMed Google Scholar
Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ (2011) Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology 32:50–57
Article CAS PubMed Google Scholar
Grochowicz PM, Schedlowski M, Husband AJ, King MG, Hibberd AD, Bowen KM (1991) Behavioral conditioning prolongs heart allograft survival in rats. Brain Behav Immun 5:349–356
Article CAS PubMed Google Scholar
Hadamitzky M, Schedlowski M (2022) Harnessing associative learning paradigms to optimize drug treatment. Trends Pharmacol Sci 43:464–472
Article CAS PubMed Google Scholar
Hadamitzky M, Herring A, Keyvani K, Doenlen R, Krugel U, Bosche K, Orlowski K, Engler H, Schedlowski M (2014) Acute systemic rapamycin induces neurobehavioral alterations in rats. Behav Brain Res 273:16–22
Article CAS PubMed Google Scholar
Hadamitzky M, Bosche K, Wirth T, Buck B, Beetz O, Christians U, Schniedewind B, Luckemann L, Gunturkun O, Engler H, Schedlowski M (2016) Memory-updating abrogates extinction of learned immunosuppression. Brain Behav Immun 52:40–48
Article CAS PubMed Google Scholar
Hadamitzky M, Herring A, Kirchhof J, Bendix I, Haight MJ, Keyvani K, Lückemann L, Unteroberdörster M, Schedlowski M (2018) Repeated systemic treatment with Rapamycin affects behavior and amygdala protein expression in rats. Int J Neuropsychopharmacol 21:592–602
Article CAS PubMed PubMed Central Google Scholar
Hadamitzky M, Lückemann L, Pacheco-López G, Schedlowski M (2020) Pavlovian conditioning of immunological and neuroendocrine functions. Physiol Rev 100:357–405
Article CAS PubMed Google Scholar
Herz J, Köster C, Crasmöller M, Abberger H, Hansen W, Felderhoff-Müser U, Bendix I (2018) Peripheral T cell depletion by FTY720 exacerbates hypoxic-ischemic brain Injury in neonatal mice. Front Immunol 9:1696
Article PubMed PubMed Central Google Scholar
Hetze S, Barthel L, Lückemann L, Günther HS, Wülfing C, Salem Y, Jakobs M, Hörbelt-Grünheidt T, Petschulat J, Bendix I, Weber-Stadlbauer U, Sure U, Schedlowski M, Hadamitzky M (2022) Taste-immune associative learning amplifies immunopharmacological effects and attenuates disease progression in a rat glioblastoma model. Brain Behav Immun 106:270–279
Article CAS PubMed Google Scholar
Hörbelt T, Martínez-Gómez EM, Hadamitzky M, Schedlowski M, Lückemann L (2019) Behaviorally conditioned immunosuppression with cyclosporine a forms long lasting memory trace. Behav Brain Res 376:112208
Ingwersen J, Aktas O, Kuery P, Kieseier B, Boyko A, Hartung HP (2012) Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy. Clin Immunol 142:15–24
Article CAS PubMed Google Scholar
Kirchhof J, Petrakova L, Brinkhoff A, Benson S, Schmidt J, Unteroberdörster M, Wilde B, Kaptchuk TJ, Witzke O, Schedlowski M (2018) Learned immunosuppressive placebo responses in renal transplant patients. Proc Natl Acad Sci U S A 115:4223–4227
Article CAS PubMed PubMed Central Google Scholar
Klosterhalfen W, Klosterhalfen S (1983) Pavlovian conditioning of immunosuppression modifies adjuvant arthritis in rats. Behav Neurosci 97:663–666
Article CAS PubMed Google Scholar
Kovarik JM, Schmouder R, Barilla D, Wang Y, Kraus G (2004) Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects. Br J Clin Pharmacol 57:586–591
Article CAS PubMed PubMed Central Google Scholar
Krivinko JM, Erickson SL, MacDonald ML, Garver ME, Sweet RA (2022) Fingolimod mitigates synaptic deficits and psychosis-like behavior in APP/PSEN1 mice. Alzheimers Dement (N Y), 8, e12324
Leisengang S, Schedlowski M, Hadamitzky M, Lückemann L (2022) Taste-associative learning in rats: conditioned immunosuppression with cyclosporine A to Study the Neuro-Immune Network. Curr Protoc 2:e573
Comments (0)