Abdallah CG, Sanacora G, Duman RS, Krystal JH (2015) Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics. Annu Rev Med 66:509–523. https://doi.org/10.1146/annurev-med-053013-062946

Article  CAS  PubMed  Google Scholar 

Bachiller S, Jiménez-Ferrer I, Paulus A, Yang Y, Swanberg M, Deierborg T, Boza-Serrano A (2018) Microglia in Neurological diseases: a Road Map to Brain-Disease Dependent-Inflammatory response. Front Cell Neurosci 12:488. https://doi.org/10.3389/fncel.2018.00488

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borgonetti V, Governa P, Biagi M, Pellati F, Galeotti N (2020) Zingiber officinale Roscoe Rhizome extract alleviates neuropathic pain by inhibiting neuroinflammation in mice. Phytomedicine 78:153307. https://doi.org/10.1016/j.phymed.2020.153307

Article  CAS  PubMed  Google Scholar 

Choi AJ, Ryter SW (2014) Inflammasomes: molecular regulation and implications for metabolic and cognitive diseases. Mol Cells 37:441–448. https://doi.org/10.14348/molcells.2014.0104

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coley AA, Gao WJ (2018) PSD95: a synaptic protein implicated in schizophrenia or autism? Prog Neuropsychopharmacol Biol Psychiatry 82:187–194. https://doi.org/10.1016/j.pnpbp.2017.11.016

Article  CAS  PubMed  Google Scholar 

Dang R, Zhou X, Tang M, Xu P, Gong X, Liu Y, Jiao H, Jiang P (2018) Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide. Eur J Nutr 57:893–906. https://doi.org/10.1007/s00394-016-1373-z

Article  CAS  PubMed  Google Scholar 

Drevets WC, Price JL, Furey ML (2008) Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct Funct 213:93–118. https://doi.org/10.1007/s00429-008-0189-x

Article  PubMed  PubMed Central  Google Scholar 

Duman RS, Aghajanian GK (2012) Synaptic dysfunction in depression: potential therapeutic targets. Science 338:68–72. https://doi.org/10.1126/science.1222939

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duman RS, Aghajanian GK, Sanacora G, Krystal JH (2016) Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med 22:238–249. https://doi.org/10.1038/nm.4050

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang Y, Wan C, Wen Y, Wu Z, Pan J, Zhong M, Zhong N (2021) Autism-associated synaptic vesicle transcripts are differentially expressed in maternal plasma exosomes of physiopathologic pregnancies. J Transl Med 19:154. https://doi.org/10.1186/s12967-021-02821-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ge F, Yang H, Lu W, Shi H, Chen Q, Luo Y, Liu L, Yan J (2020) Ovariectomy induces microglial cell activation and inflammatory response in Rat Prefrontal cortices to accelerate the chronic unpredictable stress-mediated anxiety and depression. Biomed Res Int 2020(3609758). https://doi.org/10.1155/2020/3609758

Gravina G, Svedin P, Ardalan M, Levy O, Ek CJ, Mallard C, Lai JCY (2020) Staphylococcus epidermidis sensitizes Perinatal Hypoxic-Ischemic Brain Injury in male but not female mice. Front Immunol 11:516. https://doi.org/10.3389/fimmu.2020.00516

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han JJ, Li X, Ye ZQ, Lu XY, Yang T, Tian J, Wang YQ, Zhu L, Wang ZZ, Zhang Y (2019) Treatment with 6-Gingerol regulates dendritic cell activity and ameliorates the severity of experimental autoimmune encephalomyelitis. Mol Nutr Food Res 63:e1801356. https://doi.org/10.1002/mnfr.201801356

Article  CAS  PubMed  Google Scholar 

Han X, Liu P, Liu M, Wei Z, Fan S, Wang X, Sun S, Chu L (2020) [6]-Gingerol ameliorates ISO-Induced Myocardial Fibrosis by reducing oxidative stress, inflammation, and apoptosis through inhibition of TLR4/MAPKs/NF-κB pathway. Mol Nutr Food Res 64:e2000003. https://doi.org/10.1002/mnfr.202000003

Article  CAS  PubMed  Google Scholar 

Haneklaus M, O’Neill LA, Coll RC (2013) Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments. Curr Opin Immunol 25:40–45. https://doi.org/10.1016/j.coi.2012.12.004

Article  CAS  PubMed  Google Scholar 

Hu P, Wang D, Zhang Y, Cai Z, Ye T, Tong L, Xu X, Lu J, Liu F, Lu X, Huang C (2020) Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. Neuropharmacology 170:108054. https://doi.org/10.1016/j.neuropharm.2020.108054

Article  CAS  PubMed  Google Scholar 

Iwata M, Ota KT, Duman RS (2013) The inflammasome: pathways linking psychological stress, depression, and systemic illnesses. Brain Behav Immun 31:105–114. https://doi.org/10.1016/j.bbi.2012.12.008

Article  CAS  PubMed  Google Scholar 

Iwata M, Ota KT, Li XY, Sakaue F, Li N, Dutheil S, Banasr M, Duric V, Yamanashi T, Kaneko K, Rasmussen K, Glasebrook A, Koester A, Song D, Jones KA, Zorn S, Smagin G, Duman RS (2016) Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor. Biol Psychiatry 80:12–22. https://doi.org/10.1016/j.biopsych.2015.11.026

Article  CAS  PubMed  Google Scholar 

Jiang P, Guo Y, Dang R, Yang M, Liao D, Li H, Sun Z, Feng Q, Xu P (2017) Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome. J Neuroinflammation 14:239. https://doi.org/10.1186/s12974-017-1013-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnston KM, Powell LC, Anderson IM, Szabo S, Cline S (2019) The burden of treatment-resistant depression: a systematic review of the economic and quality of life literature. J Affect Disord 242:195–210. https://doi.org/10.1016/j.jad.2018.06.045

Article  PubMed  Google Scholar 

Kang HJ, Voleti B, Hajszan T, Rajkowska G, Stockmeier CA, Licznerski P, Lepack A, Majik MS, Jeong LS, Banasr M, Son H, Duman RS (2012) Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nat Med 18:1413–1417. https://doi.org/10.1038/nm.2886

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim CY, Seo Y, Lee C, Park GH, Jang JH (2018) Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice. Evid Based Complement Alternat Med, 2018, 8941564. https://doi.org/10.1155/2018/8941564

König H, König HH, Konnopka A (2019) The excess costs of depression: a systematic review and meta-analysis. Epidemiol Psychiatr Sci 29:e30. https://doi.org/10.1017/s2045796019000180

Article  PubMed  PubMed Central  Google Scholar 

Konnopka A, König H (2020) Economic burden of anxiety disorders: a systematic review and Meta-analysis. PharmacoEconomics 38:25–37. https://doi.org/10.1007/s40273-019-00849-7

Article  PubMed  Google Scholar 

Kreisel T, Frank MG, Licht T, Reshef R, Ben-Menachem-Zidon O, Baratta MV, Maier SF, Yirmiya R (2014) Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol Psychiatry 19:699–709. https://doi.org/10.1038/mp.2013.155

Article  CAS  PubMed  Google Scholar 

Lemprière S (2020) NLRP3 inflammasome activity as biomarker for primary progressive multiple sclerosis. Nat Rev Neurol 16:350. https://doi.org/10.1038/s41582-020-0366-y

Article  PubMed  Google Scholar 

Li Y, Xu B, Xu M, Chen D, Xiong Y, Lian M, Sun Y, Tang Z, Wang L, Jiang C, Lin Y (2017) 6-Gingerol protects intestinal barrier from ischemia/reperfusion-induced damage via inhibition of p38 MAPK to NF-κB signalling. Pharmacol Res 119:137–148. https://doi.org/10.1016/j.phrs.2017.01.026

Article  CAS  PubMed  Google Scholar 

Lim GY, Tam WW, Lu Y, Ho CS, Zhang MW, Ho RC (2022) Author correction: prevalence of Depression in the community from 30 countries between 1994 and 2014. Sci Rep 12:14856. https://doi.org/10.1038/s41598-022-19021-x