Archana I, Vijayalakshmi K (2018) Antioxidant potential of phlorogucinol; an in vitro approach. Int J Pharm Sci Res 9:2947–2951. https://doi.org/10.13040/IJPSR.0975-8232.9

Biswas SK (2016) Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox? Oxid Med Cell Longev 2016:5698931. https://doi.org/10.1155/2016/5698931

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao G, Alessio HM, Cutler RG (1993) Oxygen-radical absorbance capacity assay for antioxidants. Free Rad Bio Med 14:303–311. https://doi.org/10.1016/0891-5849(93)90027-r

Article  CAS  Google Scholar 

De Souza AM, De Oliveira CF, De Oliveira VB, Betim FCM, Miguel OG, Miguel MD (2018) Traditional uses, phytochemistry, and antimicrobial activities of Eugenia species - a review. Planta Med 84:1232–1248. https://doi.org/10.1055/a-0656-7262

Article  CAS  PubMed  Google Scholar 

Dinis CP, Maderia VM, Almeida LM (1994) Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxy radical scavengers. Arch Biochem Biophys 315:161–169. https://doi.org/10.1006/abbi.1994.1485

Article  CAS  PubMed  Google Scholar 

Faqueti LG, Farias IV, Sabedot EC, Delle Monache F, San Feliciano A, Schuquel ITA, Cechinel-Filho V, Bella Cruz A, Meyre-Silva C (2015) Macrocarpal-like compounds from Eugenia umbelliflora fruits and their antibacterial activity. J Agric Food Chem 63:8151–8155. https://doi.org/10.1021/acs.jafc.5b03562

Article  CAS  PubMed  Google Scholar 

Farias IV, Amorim CM, Graff E, Breia I, dos Santos MC, Norberto S, Faqueti LG, Bresolin TMB, Bella Cruz A, Meyre-Silva C (2022) Improvement in phloroglucinol compound extracted from different parts of Eugenia umbelliflora monitored by LC-UV and antimicrobial activity. Nat Prod Res 36:3713–3716. https://doi.org/10.1080/14786419.2020.1868458

Article  CAS  PubMed  Google Scholar 

Fujinami Y, Tai A, Yamamoto I (2001) Radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl of ascorbic acid 2-glucoside (AA-2G) and 6-acyl-AA-2G. Chem Pharm Bull 49:642–644. https://doi.org/10.1248/cpb.49.642

Article  CAS  Google Scholar 

Goldoni FC, Barretta C, Nunes R, Broering MF, De Faveri R, Molleri HT, Corrêa TP, Farias IV, Amorin, CK, Pastor MVD, Meyre-Silva C, Bresolin TMB, de Freitas RA, Quintão NLM, Santin JR (2019) Effects of Eugenia umbelliflora O. Berg (Myrtaceae)-leaf extract on inflammation and hypersensitivity. J Ethnopharmacol 244:112-133. https://doi.org/10.1016/j.jep.2019.112133

Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 126:131–138. https://doi.org/10.1016/0003-2697(82)90118-X

Article  CAS  PubMed  Google Scholar 

Gulçin I (2020) Antioxidants and antioxidant methods: an updated overview. ArchToxicol 94:651–715. https://doi.org/10.1007/s00204-020-02689-3

Article  CAS  Google Scholar 

Hai P, Rao K, Jiang N, Lui D, Wang R, Gao Y, Liu X, Deng S, Zhou Y, Chen X, Li X, Li E (2022) Structure elucidation, biogenesis, and bioactivities of acylphloroglucinol-derived meroterpenoid enantiomers from Dryopteris crassirhizoma. Bioorg Chem 119:105–567. https://doi.org/10.1016/j.bioorg.2021.105567

Article  CAS  Google Scholar 

Han SC, Kang NJ, Kang GJ, Koh YS, Hyun JW, Lee NH, Kang HK, Yoo ES (2014) 71: anti-inflammatory effect of diphlorethohydroxycarmalol (DPHC) isolated from lshige okamuarae in vitro and in vivo. Cytokine 70:44–45. https://doi.org/10.1016/j.cyto.2014.07.078

Article  Google Scholar 

He L, He T, Farrar S, Ji L, Liu T, Ma X (2017) Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem 44:532-553. https://doi.org/10.1159/000485089.

Hensley K, Robinson KA, Gabbita SP, Salsman S, Floyd RA (2000) Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med 28:456-1462. https://doi.org/10.1016/s0891-5849(00)00252-5

Hillwig ML, Hammer KDP, Birt DF, Wurtele ES (2008) Characterizing the metabolic fingerprint and anti-inflammatory activity of Hypericum gentianoides. J Agric Food Chem 56:4359–4366. https://doi.org/10.1021/jf800411v

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kraus B, Wolff H, Elstner EF, Heilmann J (2010) Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages. Naunyn-Schmiedeb Arch Pharmacol 381:541–553. https://doi.org/10.1007/s00210-010-0512-y

Article  CAS  Google Scholar 

Kuskoski EM, Veja JM, Rios JJ, Fett R, Troncoso AM, Asuero AG (2003) Characterization of anthocyanins from the fruits of baguaçu (Eugenia umbelliflora Berg). J Agric Food Chem 51:5450–5454. https://doi.org/10.1021/jf030014z

Article  CAS  PubMed  Google Scholar 

Lee KJ, Oh YC, Cho WK, Ma JY (2015) Antioxidant and anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assay. Evid-Based Compl Alt M 2015:165457. https://doi.org/10.1155/2015/165457

Article  Google Scholar 

Marmitt DJ, Bitencourt S, Silva GR, Rempel C, Goettert MI (2021) Traditional plants with antioxidant properties in clinical trials—a systematic review. Phytother Res 35:5647–5667. https://doi.org/10.1002/ptr.7202

Article  PubMed  Google Scholar 

Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB (2014) Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal 20:1126–1167. https://doi.org/10.1089/ars.2012.5149

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55–63

Article  CAS  PubMed  Google Scholar 

Mucha P, Skoczynska A, Malecka M, Hikisz P, Budzisz E (2021) Review: overview of the antioxidant and anti-inflammatory activities of selected plant compounds and their metal ions complexes. Molecules 26:1–52. https://doi.org/10.3390/molecules26164886

Article  CAS  Google Scholar 

Spiegel M, Andruniów T, Sroka Z (2020) Flavones’ and flavonols’ antiradical structure–activity relationship—a quantum chemical study. Antioxidants 9:461. https://doi.org/10.3390/antiox9060461

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu XF, Li L, Li Y, Lv HN, Liu YB, Hu YC (2017) Phloroglucinols with antioxidant activities isolated from Lysidice rhodostegia. Molecules 22:855. https://doi.org/10.3390/molecules22060855

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao F, Xu T, Lu B, Liu R (2020) Guidelines for antioxidant assays for food components. Food Front 1:60–69. https://doi.org/10.1002/fft2.10

Article  Google Scholar 

Zhou X, Xu W, Li Y, Zhang M, Tang P, Lu W, Li Q, Zhang H, Luo J, Kong L (2021) Anti-inflammatory, antioxidant, and anti-nonalcoholic steatohepatitis acylphloroglucinol meroterpenoids from Hypericum bellum flower. J Agric Food Chem 69:646–654. https://doi.org/10.1021/acs.jafc.0c05417

Article  CAS  PubMed  Google Scholar