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• Comprehensive understanding of the potential toxicities linked to MET-selective TKIs is still lacking.

• Gastrointestinal disorders, respiratory toxicity, hepatotoxicity, and disturbances in metabolism and nutrition were prevalent and significant among the adverse event categories.

• Peripheral edema, nausea, dysphagia, fatigue, and dyspnea were the most commonly reported adverse events.

• These adverse events were observed primarily within the initial months of treatment initiation and persisted thereafter.

• Capmatinib usage showed a significant correlation with hearing loss and difficulty in swallowing.