Ahluwalia TS, Prins BP, Abdollahi M et al (2021) Genome-wide association study of circulating interleukin 6 levels identifies novel loci. Hum Mol Genet 30(5):393–409

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balakrishnan R, Thurmond DC (2022) Mechanisms by which skeletal muscle myokines ameliorate insulin resistance. Int J Mol Sci 23(9):4636

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bousseau S, SobranoFais R, Gu S et al (2023) Pathophysiology and new advances in pulmonary hypertension. BMJ Med 2(1):e000137

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: Effect estimation and bias detection through egger regression. Int J Epidemiol 44(2):512–525

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Haycock PC et al (2016) Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol 40(4):304–314

Article  PubMed  PubMed Central  Google Scholar 

Brands MW, Banes-Berceli AK, Inscho EW et al (2010) Interleukin 6 knockout prevents angiotensin ii hypertension: Role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation. Hypertension 56(5):879–884

Article  CAS  PubMed  Google Scholar 

Chae CU, Lee RT, Rifai N et al (2001) Blood pressure and inflammation in apparently healthy men. Hypertension 38(3):399–403

Article  CAS  PubMed  Google Scholar 

Copur S, Peltek IB, Mutlu A et al (2023) A new immune disease: Systemic hypertension. Clin Kidney J 16(9):1403–1419

Article  CAS  PubMed  PubMed Central  Google Scholar 

Courboulin A, Tremblay VL, Barrier M et al (2011) Kruppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension. Respir Res 12(1):128

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dakroub A, Nasser SA, Kobeissy F et al (2021) Visfatin: An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases. J Cell Physiol 236(9):6282–6296

Article  CAS  PubMed  Google Scholar 

Davey Smith G, Hemani G (2014) Mendelian randomization: Genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 23(R1):R89-98

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davies RJ, Holmes AM, Deighton J et al (2012) Bmp type ii receptor deficiency confers resistance to growth inhibition by tgf-beta in pulmonary artery smooth muscle cells: Role of proinflammatory cytokines. Am J Physiol Lung Cell Mol Physiol 302(6):L604-615

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davis GK, Fehrenbach DJ, Madhur MS (2021) interleukin 17a: key player in the pathogenesis of hypertension and a potential therapeutic target. Curr Hypertens Rep 23(3):13

Article  CAS  PubMed  PubMed Central  Google Scholar 

Didion SP (2017) Cellular and oxidative mechanisms associated with interleukin-6 signaling in the vasculature. Int J Mol Sci 18(12):2563

Article  PubMed  PubMed Central  Google Scholar 

Dzau VJ, Balatbat CA (2019) Future of hypertension. Hypertension 74(3):450–457

Article  CAS  PubMed  Google Scholar 

Evangelou E, Warren HR, Mosen-Ansorena D et al (2018) Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet 50(10):1412–1425

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng Y, Ye D, Wang Z et al (2022) The role of interleukin-6 family members in cardiovascular diseases. Front Cardiovasc Med 9:818890

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fisher G, Hunter GR, Glasser SP (2013) Associations between arterial elasticity and markers of inflammation in healthy older women. J Gerontol A Biol Sci Med Sci 68(4):382–388

Article  CAS  PubMed  Google Scholar 

Fletcher GF, Balady GJ, Amsterdam EA et al (2001) Exercise standards for testing and training: A statement for healthcare professionals from the american heart association. Circulation 104(14):1694–1740

Article  CAS  PubMed  Google Scholar 

Fontes JA, Rose NR, Cihakova D (2015) The varying faces of il-6: From cardiac protection to cardiac failure. Cytokine 74(1):62–68

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fuchs FD, Whelton PK (2020) High blood pressure and cardiovascular disease. Hypertension 75(2):285–292

Article  CAS  PubMed  Google Scholar 

Furuya Y, Satoh T, Kuwana M (2010) Interleukin-6 as a potential therapeutic target for pulmonary arterial hypertension. Int J Rheumatol 2010:720305

Article  PubMed  PubMed Central  Google Scholar 

Galie N, McLaughlin VV, Rubin LJ et al (2019) An overview of the 6th world symposium on pulmonary hypertension. Eur Respir J 53(1):1802148

Article  PubMed  PubMed Central  Google Scholar 

Georgakis MK, Malik R, Gill D et al (2020) Interleukin-6 signaling effects on ischemic stroke and other cardiovascular outcomes: a mendelian randomization study. Circ Genom Precis Med 13(3):e002872

Article  PubMed  PubMed Central  Google Scholar 

Gijon-Conde T, Sanchez-Martinez M, Graciani A et al (2019) Impact of the european and american guidelines on hypertension prevalence, treatment, and cardiometabolic goals. J Hypertens 37(7):1393–1400

Article  CAS  PubMed  Google Scholar 

Guignabert C, Tu L, Girerd B et al (2015) New molecular targets of pulmonary vascular remodeling in pulmonary arterial hypertension: Importance of endothelial communication. Chest 147(2):529–537

Article  PubMed  Google Scholar 

Gurzau D, Sitar-Taut A, Caloian B et al (2021) The role of il-6 and et-1 in the diagnosis of coronary microvascular disease in women. J Pers Med 11(10):965

Article  PubMed  PubMed Central  Google Scholar 

Haider AW, Larson MG, Franklin SS et al (2003) Systolic blood pressure, diastolic blood pressure, and pulse pressure as predictors of risk for congestive heart failure in the Framingham heart study. Ann Intern Med 138(1):10–16

Article  PubMed  Google Scholar 

Hanna A, Frangogiannis NG (2020) Inflammatory cytokines and chemokines as therapeutic targets in heart failure. Cardiovasc Drugs Ther 34(6):849–863

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hartley AE, Power GM, Sanderson E et al (2022) A guide for understanding and designing mendelian randomization studies in the musculoskeletal field. JBMR plus 6(10):e10675

Article  PubMed  PubMed Central  Google Scholar 

Heink S, Yogev N, Garbers C et al (2017) Trans-presentation of il-6 by dendritic cells is required for the priming of pathogenic t(h)17 cells. Nat Immunol 18(1):74–85

Article  CAS  PubMed  Google Scholar 

Hirano T (2021) Il-6 in inflammation, autoimmunity and cancer. Int Immunol 33(3):127–148

Article  CAS  PubMed  Google Scholar 

Hirsch K, Nolley S, Ralph DD et al (2023) Circulating markers of inflammation and angiogenesis and clinical outcomes across subtypes of pulmonary arterial hypertension. J Heart Lung Transplant 42(2):173–182

Article  PubMed  Google Scholar 

Hong J, Qu Z, Ji X et al (2021) Genetic associations between il-6 and the development of autoimmune arthritis are gender-specific. Front Immunol 12:707617

Article  CAS  PubMed  PubMed Central  Google Scholar 

Humbert M, Monti G, Brenot F et al (1995) Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med 151(5):1628–1631

Article  CAS  PubMed  Google Scholar 

Hu X, Zhao J, Lin Z et al (2022) Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics. Proc Natl Acad Sci U S A 119(28):e2106858119

Article  CAS  PubMed  PubMed Central