Kuenzig ME, Fung SG, Marderfeld L, Mak JWY, Kaplan GG, Ng SC, Wilson DC, Cameron F, Henderson P, Kotze PG, Bhatti J, Fang V, Gerber S, Guay E, Kotteduwa Jayawarden S, Kadota L, Maldonado DF, Osei JA, Sandarage R, Stanton A, Wan M, Benchimol EI (2022) Twenty-first century trends in the global epidemiology of pediatric-onset inflammatory bowel disease: Systematic review. Gastroenterology 162:1147–1159.e4. https://doi.org/10.1053/j.gastro.2021.12.282
Ledder O, Turner D (2023) Multi-item measures for paediatric inflammatory bowel diseases: the ABCs of all those acronyms. J Crohns Colitis 17:1154–1168. https://doi.org/10.1093/ecco-jcc/jjad019
Pineton de Chambrun G, Peyrin-Biroulet L, Lémann M, Colombel J-F (2010) Clinical implications of mucosal healing for the management of IBD. Nat Rev Gastroenterol Hepatol 7:15–29. https://doi.org/10.1038/nrgastro.2009.203
D’Haens G, Sandborn WJ, Feagan BG, Geboes K, Hanauer SB, Irvine EJ, Lémann M, Marteau P, Rutgeerts P, Schölmerich J, Sutherland LR (2007) A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology 132:763–786. https://doi.org/10.1053/j.gastro.2006.12.038
Article CAS PubMed Google Scholar
Christensen B, Hanauer SB, Erlich J, Kassim O, Gibson PR, Turner JR, Hart J, Rubin DT (2017) Histologic normalization occurs in ulcerative colitis and is associated with improved clinical outcomes. Clin Gastroenterol Hepatol 15:1557-1564.e1. https://doi.org/10.1016/j.cgh.2017.02.016
Article PubMed PubMed Central Google Scholar
Narula N, Wong ECL, Colombel J-F, Riddell R, Marshall JK, Reinisch W, Dulai PS (2022) Early change in epithelial neutrophilic infiltrate predicts long-term response to biologics in ulcerative colitis. Clin Gastroenterol Hepatol 20:1095-1104.e9. https://doi.org/10.1016/j.cgh.2021.07.005
Article CAS PubMed Google Scholar
Schroeder KW, Tremaine WJ, Ilstrup DM (1987) Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. N Engl J Med 317:1625–1629. https://doi.org/10.1056/NEJM198712243172603
Article CAS PubMed Google Scholar
Annese V, Daperno M, Rutter MD, Amiot A, Bossuyt P, East J, Ferrante M, Götz M, Katsanos KH, Kießlich R, Ordás I, Repici A, Rosa B, Sebastian S, Kucharzik T, Eliakim R (2013) European evidence based consensus for endoscopy in inflammatory bowel disease. J Crohns Colitis 7:982–1018. https://doi.org/10.1016/j.crohns.2013.09.016
Marchal-Bressenot A, Salleron J, Boulagnon-Rombi C, Bastien C, Cahn V, Cadiot G, Diebold M-D, Danese S, Reinisch W, Schreiber S, Travis S, Peyrin-Biroulet L (2017) Development and validation of the Nancy histological index for UC. Gut 66:43–49. https://doi.org/10.1136/gutjnl-2015-310187
Ma C, Sedano R, Almradi A, Vande Casteele N, Parker CE, Guizzetti L, Schaeffer DF, Riddell RH, Pai RK, Battat R, Sands BE, Rosty C, Dubinsky MC, Rieder F, Harpaz N, Abreu MT, Bryant RV, Lauwers GY, Kirsch R, Valasek MA, Crowley E, Sandborn WJ, Feagan BG, Pai RK, Jairath V (2021) An international consensus to standardize integration of histopathology in ulcerative colitis clinical trials. Gastroenterology 160:2291–2302. https://doi.org/10.1053/j.gastro.2021.02.035
Magro F, Doherty G, Peyrin-Biroulet L, Svrcek M, Borralho P, Walsh A, Carneiro F, Rosini F, de Hertogh G, Biedermann L, Pouillon L, Scharl M, Tripathi M, Danese S, Villanacci V, Feakins R (2020) ECCO position paper: harmonization of the approach to ulcerative colitis histopathology. J Crohns Colitis 14:1503–1511. https://doi.org/10.1093/ecco-jcc/jjaa110
Coté CJ, Wilson S, American Academy of Pediatrics, American Academy of Pediatric Dentistry (2019) Guidelines for monitoring and management of pediatric patients before, during, and after sedation for diagnostic and therapeutic procedures. Pediatrics 143:e20191000. https://doi.org/10.1542/peds.2019-1000
Thomson M, Tringali A, Dumonceau J-M, Tavares M, Tabbers MM, Furlano R, Spaander M, Hassan C, Tzvinikos C, Ijsselstijn H, Viala J, Dall’Oglio L, Benninga M, Orel R, Vandenplas Y, Keil R, Romano C, Brownstone E, Hlava Š, Gerner P, Dolak W, Landi R, Huber WD, Everett S, Vecsei A, Aabakken L, Amil-Dias J, Zambelli A (2017) Paediatric gastrointestinal endoscopy: European society for paediatric gastroenterology hepatology and nutrition and European society of gastrointestinal endoscopy guidelines. J Pediatr Gastroenterol Nutr 64:133–153. https://doi.org/10.1097/MPG.0000000000001408
Turner D, Otley AR, Mack D, Hyams J, de Bruijne J, Uusoue K, Walters TD, Zachos M, Mamula P, Beaton DE, Steinhart AH, Griffiths AM (2007) Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. Gastroenterology 133:423–432. https://doi.org/10.1053/j.gastro.2007.05.029
Danese S, Roda G, Peyrin-Biroulet L (2020) Evolving therapeutic goals in ulcerative colitis: Towards disease clearance. Nat Rev Gastroenterol Hepatol 17:1–2. https://doi.org/10.1038/s41575-019-0211-1
Crowley E, Griffiths AM, Jairath V (2022) Heterogeneity in efficacy and safety endpoints for pediatric clinical trials in inflammatory bowel disease: a need for harmonization. Gastroenterology 163:1137–1144. https://doi.org/10.1053/j.gastro.2022.07.006
Park S, Abdi T, Gentry M, Laine L (2016) Histological disease activity as a predictor of clinical relapse among patients with ulcerative colitis: Systematic review and meta-analysis. Am J Gastroenterol 111:1692–1701. https://doi.org/10.1038/ajg.2016.418
Yoon H, Jangi S, Dulai PS, Boland BS, Prokop LJ, Jairath V, Feagan BG, Sandborn WJ, Singh S (2020) Incremental benefit of achieving endoscopic and histologic remission in patients with ulcerative colitis: a systematic review and meta-analysis. Gastroenterology 159:1262-1275.e7. https://doi.org/10.1053/j.gastro.2020.06.043
D’Amico F, Guillo L, Baumann C, Danese S, Peyrin-Biroulet L (2021) Histological disease activity measured by the Nancy index is associated with long-term outcomes in patients with ulcerative colitis. J Crohns Colitis 15:1631–1640. https://doi.org/10.1093/ecco-jcc/jjab063
Bryant RV, Burger DC, Delo J, Walsh AJ, Thomas S, von Herbay A, Buchel OC, White L, Brain O, Keshav S, Warren BF, Travis SPL (2016) Beyond endoscopic mucosal healing in UC: Histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up. Gut 65:408–414. https://doi.org/10.1136/gutjnl-2015-309598
Article CAS PubMed Google Scholar
Shaffer SR, Erondu AI, Traboulsi C, Rai V, Krugliak Cleveland N, Israel A, Christensen B, Rubin DT (2021) Achieving histologic normalization in ulcerative colitis is associated with a reduced risk of subsequent dysplasia. Inflamm Bowel Dis 28:553–559. https://doi.org/10.1093/ibd/izab130
Article PubMed Central Google Scholar
Turner D, Ruemmele FM, Orlanski-Meyer E, Griffiths AM, de Carpi JM, Bronsky J, Veres G, Aloi M, Strisciuglio C, Braegger CP, Assa A, Romano C, Hussey S, Stanton M, Pakarinen M, de Ridder L, Katsanos K, Croft N, Navas-López V, Wilson DC, Lawrence S, Russell RK (2018) Management of paediatric ulcerative colitis, part 1: ambulatory care-an evidence-based guideline From European Crohn’s and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 67:257–291. https://doi.org/10.1097/MPG.0000000000002035
Turner D, Ricciuto A, Lewis A, D’Amico F, Dhaliwal J, Griffiths AM, Bettenworth D, Sandborn WJ, Sands BE, Reinisch W, Schölmerich J, Bemelman W, Danese S, Mary JY, Rubin D, Colombel J-F, Peyrin-Biroulet L, Dotan I, Abreu MT, Dignass A (2021) STRIDE-II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD. Gastroenterology 160:1570–1583. https://doi.org/10.1053/j.gastro.2020.12.031
Article CAS PubMed Google Scholar
Maaser C, Sturm A, Vavricka SR, Kucharzik T, Fiorino G, Annese V, Calabrese E, Baumgart DC, Bettenworth D, Borralho Nunes P, Burisch J, Castiglione F, Eliakim R, Ellul P, González-Lama Y, Gordon H, Halligan S, Katsanos K, Kopylov U, Kotze PG, Krustinš E, Laghi A, Limdi JK, Rieder F, Rimola J, Taylor SA, Tolan D, van Rheenen P, Verstockt B, Stoker J (2019) ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: initial diagnosis, monitoring of known IBD, detection of complications. J Crohns Colitis 13:144–164. https://doi.org/10.1093/ecco-jcc/jjy113
Wirthgen E, Weber F, Kubickova-Weber L, Schiller B, Schiller S, Radke M, Däbritz J (2023) Identifying predictors of clinical outcomes using the projection-predictive feature selection — a proof of concept on the example of Crohn’s disease. Front Pediatr 11:1170563. https://doi.org/10.3389/fped.2023.1170563
Article PubMed PubMed Central Google Scholar
Levine A, Koletzko S, Turner D, Escher JC, Cucchiara S, de Ridder L, Kolho K-L, Veres G, Russell RK, Paerregaard A, Buderus S, Greer M-LC, Dias JA, Veereman-Wauters G, Lionetti P, Sladek M, Martin de Carpi J, Staiano A, Ruemmele FM, Wilson DC (2014) ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents. J Pediatr Gastroenterol Nutr 58:795–806. https://doi.org/10.1097/MPG.0000000000000239
Article CAS PubMed Google Scholar
Buderus S, Scholz D, Behrens R, Classen M, de Laffolie J, Keller K-M, Zimmer K-P, Koletzko S (2015) Inflammatory bowel disease in pediatric patients: characteristics of newly diagnosed patients from the CEDATA-GPGE Registry. Dtsch Arztebl Int 112:121–127. https://doi.org/10.3238/arztebl.2015.0121
Article PubMed PubMed Central Google Scholar
Leiz M, Knorr M, Moon K, Tischler L, Sohrabi K, Cantez S, Däbritz J, de Laffolie J, van den Berg N (2023) How can patient registries facilitate guideline-based healthcare? A retrospective analysis of the CEDATA-GPGE registry for pediatric inflammatory bowel disease. BMC Health Serv Res 23:648. https://doi.org/10.1186/s12913-023-09639-6
Article CAS PubMed PubMed Central Google Scholar
R Core Team (2023) R: a language and environment for statistical computing. Version 4.3.1. Vienna, Austria: R Foundation for Statistical Computing. Available at: https://www.R-project.org/
Bürkner PC (2017) brms: An R package for Bayesian multilevel models using Stan. J Stat Soft 80:1–28. https://doi.org/10.18637/jss.v080.i01
Bürkner PC (2018) Advanced Bayesian multilevel modeling with the R Package brms. R J 10:395–411. https://doi.org/10.32614/RJ-2018-017
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