Validation of oscillometric ratio and maximum gradient methods for non-invasive blood pressure measurement with intra-arterial blood pressure measurements as reference

aBiomedical Systems Research Laboratory, University of New South Wales

bConcord Repatriation Hospital, Cardiology, University of Sydney

cMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University

dGraduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia

Correspondence to Branko G. Celler, University of New South Wales - Kensington Campus: University of New South Wales Sydney, Sydney, NSW 2033, Australia. Tel: +61 418 228 297; fax: +61 (2) 9385 5993; e-mail: [email protected]

Abbreviations: Age, Age in years; Gender, Gender (F/M); HR, Heart rate before cuff inflation (bpm); PWV, Pulse wave velocity (m/s); dPdtmax, Max positive slope of IABP pulse (mmHg/ms); CP-Peak, Peak cuff pressure (mmHg); CDR, Cuff inflation/deflation rate (mmHg/s); SBP, Intra-arterial SBP before cuff inflation (mmHg); SBP-K, Estimate of IA-SBP (mmHg) from K1 of KSE from K1 sound; SBP-Grad, Estimate of SBP from CP (mmHg) at minimum of OWE gradient; DBP, Intra-arterial DBP before cuff inflation (mmHg); DBP-K, Estimate of IA-DBP from K4/K5 of KSE during deflation; DBP-Grad, Estimate of DBP from CP (mmHg) at maximum of OWE gradient; MP, Intra-arterial MP (mmHg) before cuff inflation; MP-OWE, Mean pressure (mmHg) estimate from CP at peak of OWE; MP-Grad, Mean pressure (mmHg) estimate from CP at intersection of lines of maximum and minimum gradient of OWE; PP, Pulse pressure (mmHg); RS, Ratio of normalized OWE∗ at which SBP occurs; RS-K, Ratio of normalized OWE at which K1 sound is first detected; RS-Grad, Ratio of normalized OWE at which negative slope is at a minimum; Slope-RS, Minimum negative slope of OWE; RD, Ratio of normalised OWE∗ at which DBP occurs; RD-K, Ratio of normalized OWE at which K4/K5 sound is first detected; RD-Grad, Ratio of normalised OWE at which positive slope is at a maximum; Slope-RD, Maximum positive slope of OWE; Kurtosis, A statistical measure of the tailedness or “peakiness” of a distribution.; Skewness, A measure of the asymmetry of the probability distribution of a real-valued random variable about its mean; OWmax, Peak amplitude of oscillometric waveform (mmHg); dOW/dtmax, Max upward slope of oscillometric waveform (mmHg/ms); OWE-Width, Distance in mmHg between points of max and min gradient on OWE; Area-Grad, Unscaled area below maximum gradient points in mm2Hg; Area-All, Unscaled area under OWE in mm2Hg

Received 4 December, 2023

Revised 1 February, 2024

Accepted 10 February, 2024

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