Hypoxic environment promotes angiogenesis and bone bridge formation by activating Notch/RBPJ signaling pathway in HUVECs

Keywords

Human umbilical vein endothelial cells

Bone mesenchymal stem cells

Notch/RBPJ signaling pathway

Osteogenic differentiation

Bone bridge

Epiphyseal plate injury

AbbreviationsVEGF

Vascular Endothelial Growth Factor

BMSCs

Bone Mesenchymal Stem Cells

HUVECs

Human Umbilical Vein Endothelial Cells

DEGs

differentially expressed genes

PBS

phosphate buffered saline

DMEM

Dulbecco's Eagle's Medium

OGD

Oxygen glucose deprivation

RT-qPCR

Quantitative Real-Time PCR

ARS

Alizarin red S solution

micro-CT

microcomputed tomography

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