In the present work, novel series of Schiff base 2-7 were synthesized via treatment of p-tosyloxy benzaldehyde with some indole and quinoxaline derivatives in ethanol under reflux. All product structures were verified using elemental analysis and spectroscopic investigations, including 13C NMR, 1H NMR, and IR. Our research was conducted on the insecticidal activity, and biological effects of the recently synthesized Schiff bases on S. frugiperda. The results showed that compound 5 was the most active insecticide, nearly surpassing methomyl as a reference, with LC50 values of 46.35 mg/L for second-instar larvae and 97.37 mg/L for fourth-instar larvae. This research opened up new avenues for the search for a novel class of insecticide.

KEY WORDS: Schiff bases, Spodoptera frugiperda, Insecticidal activity, Biological aspects, Toxicity

Bull. Chem. Soc. Ethiop. 2024, 38(3), 765-774.                                                              

DOI: https://dx.doi.org/10.4314/bcse.v38i3.17